ID A0A1Q9CQ40_SYMMI Unreviewed; 2365 AA.
AC A0A1Q9CQ40;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|ARBA:ARBA00029784, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|ARBA:ARBA00032199, ECO:0000256|RuleBase:RU366037};
GN Name=xpot {ECO:0000313|EMBL:OLP85033.1};
GN ORFNames=AK812_SmicGene34038 {ECO:0000313|EMBL:OLP85033.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLP85033.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLP85033.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLP85033.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLP85033.1}.
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DR EMBL; LSRX01000999; OLP85033.1; -; Genomic_DNA.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 1.10.238.10; EF-hand; 3.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR005645; FSH-like_dom.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF03959; FSH1; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM00054; EFh; 5.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 1583..1618
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1675..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2151..2173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2365 AA; 265327 MW; 937B49ED934D2A48 CRC64;
MDDLERAIRV IFAQDPSITP AVREEATRYC DGIKAHPDCW ILCWERLVQT EVLEVKFWCL
QVILQALSSI SPAARVELRG KVLSWLREVA GKKQEEVVVK NKVALVYAGL IKLDYPAQWP
AAWQDLIGLM DLGLPLVDFF LRVLAIFDQE VVNDEVARSN EDRQRGHQIK HAMRERDVVS
LVECWYKILT TLKGAAPHMV RDCLKVTALY VVWIEILTVA NDKFLSAVCN LIAEASDSAG
EACDCLAAIV SKKMPASKKV QMLSELQIFA RLEACVHRDG SDHQLLVKQA DMINSVGEVT
LEAYVDLRVQ SDADSARLAQ VAWESTNALM PLVFWVFAHK EHQVAVCVEP FLTEFFVKVK
SFVADGQKGD MEMAPCHSVS LEQVRPILMQ TLQLIIQRTS YPPWFQHNDP NFEDEEQHVA
FIEFRRSLTK IYKRIFLVDE QLGFQFVQAS VAQLTTNLSG VQPMEVDAVL YLFKEAGETV
RQLEQHLQVD CCIDGKQRGG ERGCRAPRER GMRILVFHGY SSNGSWQQHR DKRLQKLLSF
FNVWLHYIDG PVQLPPFSAE GIHRRLSWWS IKREGSWTKL LAYLHEVFHR DGPFDGVMGY
SQGAAVAGGL AAEMLVGHFP GMFRFAIVVC GYLAPTPDLK QLIELLDRQE RPRESHTAVL
RWRRWKSVDI PEQKSFRLPT LHIMGEADKV TPVRMNLEMA SLFADPVRVL VRHPGGHHLP
FATEPIRSLV LFLVPFMEAK DASRVLKEVG DGQELCLQCA SFRSEGASHN RRWYCEACWA
LWQSMAPLSS DDEEVGLVME LSLVEQSFYP PRGGPEASLC ATELAKGPLA GCFVQLIECD
ALVNADHWAV QLALMEVYVK YGKLFALHQE LFPRYGQKVL QALLSPRGVR SNNPHLAARA
CFMFGRFVKL VRVQAAALVV QIHEALQDLL IVQYVPSALL PVQAEVSLTK VAVKGALKAD
DQANLFEALA CLAAASRPEE LPAKLEMLLK GPAQNLSEIV TDAAASRAGN DIAGCAGWAG
RSIEAIATVS KAFNVSHAST ATAWEQVLMI VARILEKFVN QLNREIGLWR AALFLCRRMV
EVLGDRFLTV LDTLFPFLYA TNDQADLTEL TIFAHHLVCQ YQKKTQPHLQ KWPKLSDVFS
GSWSKNLVQR INKIEFSEVL RKYQYPGNIQ KLFSELDDDR SGEITMYEID PAQAAAFLHK
AVAFSIGRSK AEVLWSSFRL WCIKTFRSVE ELLTRLGNTN EERLKTRLTI KARHSAITEE
QFQKRIKEMG WQHGQEKLLF SGLDCDASGK LGRESFRWLE AEFHRIQRKM EAKSRAIHSL
RKQQAREAQE QTMNRFKEYL VKKHGNLVRA WRVVLCSNDV MSIPKTPFLK ACALIGFSHE
ARDLWHVLDK DESGFAALEE LDPPSAEALA RFKAFLESRF GSVTQGFASL DSDSGKKVSY
KQFEKSLLEW GWSGHTKQLF QHLDKSGSKM IEESDFRFLE KWHPHLYFVV EANHAAREEI
RDLIGQKYGG HFLKAWRQLL DKDGSNRCSW SEFQAACHRI RYHGDVAGAW RAFDQDLSGY
ITLNELDSEA STTLSNFKSW AWREFGTVRA AFSVFDHDAS NSLTFQEFRG NCRIYGYVGN
ARQLFAALDV NQEGVLSMQE TCFLDDWEID NNSQEERTHL EKRESHIRRI DDTVRKHVQK
QARPERLSEL SCRSHSKRSL KSDSSIGDDP EFVDESDRSS KVAQVKQTLQ MRADLPLIPL
YTWPHRDEIE VALLAIRDRE RKHWVQEAAD DWVFMGQFKE LAQDMMLGEV HRPDDGGKRV
ALTGYLPARI PRLHQTFLRP LAVWQQMPEQ SDQLKREKLE LGNAMLQLLK EAAQRCPSAL
LEPMLTNTRH GQEMTGFLLV GLQDAREIKA VLYSASAWAA LLEAATSSSE AAAAIASLPI
AQLLQRMLWS AARMDYNDIQ SQKVLSEAAS ILRSVMNPRV QPQAQLEQTK EAFQQSLVGA
LPGLQSEIGP RQLGEVLLQE APLKDVRTTL QQCMLQWQRA LHMVCADQGV ALFWDPPASC
TLATAFAMGW TFVPWLLLIS RASGIDKPEG CSDEAWNFVC LGALSCADLA SAGITCTGIG
SLDTCSTACA SPCCVTTTTT TQTVTATTVT SVTHTETSTS ISETATTTHT LTETSITSTA
SETSTHTATE TETMTTTATH TITHTITEIS ESTVPPSTTT EIEPAAVERL SVRAVVTDVT
MYVDYIRDSR IINAYKHVME DISGLSEHWI ALQMFPGAAG NITVDYILTV PFVEGAGGEL
VPIVPVEQVQ GKLDAVTPGT FNTMLKEKVD EATGAGTHSQ KVVSFEQDTS DSGNGSVSSA
LRLGAPLKCS LASIIFLMLA SIVGS
//
