ID A0A1Q9CX02_SYMMI Unreviewed; 624 AA.
AC A0A1Q9CX02;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Radical S-adenosyl methionine domain-containing protein 2 {ECO:0000313|EMBL:OLP87437.1};
GN Name=Rsad2 {ECO:0000313|EMBL:OLP87437.1};
GN ORFNames=AK812_SmicGene31322 {ECO:0000313|EMBL:OLP87437.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLP87437.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLP87437.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLP87437.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLP87437.1}.
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DR EMBL; LSRX01000860; OLP87437.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q9CX02; -.
DR OrthoDB; 3671494at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR NCBIfam; NF038283; viperin_w_prok; 1.
DR PANTHER; PTHR21339; RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR21339:SF0; RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SFLD; SFLDG01088; antiviral_proteins; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SFLD; SFLDF00318; Viperin; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Plastid {ECO:0000256|ARBA:ARBA00022640};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 266..489
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 624 AA; 69653 MW; 269BB717356ABDE8 CRC64;
MNNHIVVAEL AAEGPDMPQT TMFQSVEAAC RVLERDPTGR EAVGIWRSIE VQTLQGTPLS
DEPIVILEGA DGVGKSTLAE NLQRSMNASV VKTPPKPLGH FRQYFDSADA ELRRAFYILG
NYVCAYGLRW LSPTQPIIVD RFWPSSAAYA LACDLQSSAC QHPEIAEMPK DLVDLLSFGS
RPIVFLVLDL PEKVRASRVR GRPGIITQEE ESLERDEALR GSLARAYAAL RLPEGQVMSF
LDASGGPGDV LQRALTIIRS KMEEFRASPV PLSVNWHYTR QCNYTCKFCF HTAKTSFFLP
QTKQGMDEAK QCLRRLQWAG MQKLNFSGGE PFLHEKELGE LCRFCKEDLA LESVSIVSNG
SKITGDWIRK HGSYVDILAI SCDSFQEEIN LKIGRGKGSH LQQLQQIRQW CEEADIKFKV
NTVVNKMNIN EDMRDMIRRL NPVRWKVFQC LLLEGENAGE EALRNARRLT VSSEEFQGFL
DRHSQIDCLV PEDNEKMKDS YLILDEFMRF LNCTGGAKTP TASLRDVPVI SALKGAGFDS
KMFLTRGGVY DWTRQRADGC AGEGADLEDL AGSRTTPRRT PLRTGIPINS PRPWGQVHVL
TAAAFLAAGV MIAVGSRSRM VPAR
//
