ID A0A1Q9CXU4_SYMMI Unreviewed; 4257 AA.
AC A0A1Q9CXU4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=NmrA-like family domain-containing protein 1 {ECO:0000313|EMBL:OLP87731.1};
GN Name=NMRAL1 {ECO:0000313|EMBL:OLP87731.1};
GN ORFNames=AK812_SmicGene31030 {ECO:0000313|EMBL:OLP87731.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLP87731.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLP87731.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLP87731.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NmrA-type oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00006328}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLP87731.1}.
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DR EMBL; LSRX01000845; OLP87731.1; -; Genomic_DNA.
DR OrthoDB; 2970339at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd15777; CRBN_C_like; 1.
DR CDD; cd06174; MFS; 1.
DR CDD; cd05251; NmrA_like_SDR_a; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 2.170.150.20; Peptide methionine sulfoxide reductase; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR034750; CULT.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR008030; NmrA-like.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR010308; TRP_C.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR42748; NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER; 1.
DR PANTHER; PTHR42748:SF7; NMRA-LIKE FAMILY DOMAIN-CONTAINING PROTEIN DDB_G0286605; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07699; Ephrin_rec_like; 2.
DR Pfam; PF05368; NmrA; 2.
DR Pfam; PF00648; Peptidase_C2; 3.
DR Pfam; PF06011; TRP; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50203; CALPAIN_CAT; 2.
DR PROSITE; PS51788; CULT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2239..2260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2272..2296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2331..2352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2419..2442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2470..2490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2496..2517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2529..2549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2561..2584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4234..4255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1288..1402
FT /note="CULT"
FT /evidence="ECO:0000259|PROSITE:PS51788"
FT DOMAIN 2783..2832
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 3542..3637
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 165..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2671..2724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4167..4193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2671..2692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4257 AA; 466203 MW; 3F16F31009ABBB7A CRC64;
MPWRRRGCAG EGELASPGQF LDLEDLPLNV QAVIEKLSGP TAGEASLEKL VAKLAEGVMA
NYKEKKEEAL ASEQYEYVKL PNGADGCPSG SEIPTFEECR QAILSMGLKP DPYWTNAFEG
LPKFCSVRES PHETVGLERM HFNTAGRGAG RDDLAPVCRK IGTAAGGQAG KPKEAPSATK
GSQGASSALQ ELSGRTQQSF LGRDKPLWFL VYMKEGPLTE VEEEMLLNVK DRFQQKLDEQ
RIPLQWLWLD LRAERAVRSL LDPPAIPSAM VIKGGNSPKY ALVQHDEQDD EPVPADANSI
ELLLNSLLGG DARCVDVAGS AVCAAECQEA GIFVVSQEIM TDAGEAAFVR VCDRSQLAAR
PEDVCQGALG NCWFAGALSV VAQMPDLISK ICITKDLDGP SIWQLRAPKQ PASTSHPCAA
PAADRLQLSK RESPQNPGGK PFPMAELAGL ETGERVRVLG GRNFEKFHGG MEGTVVENNA
EGRNMRVQFD DAATAGAEPV TVAYRHLEAA PMPGGYRCSA KGSAAKPDSS PATGASGPVL
KEHGPWKVKQ LVQLQGLQSA PELNGRLGRL QKFDVHAERW EVEVRGDGGG TKRLKEANLT
AFVPPVVAAG LTVAELKERG NECFKASQLE EAIAFYSAAL ETAEKDGSGE IPDDPKYMAV
LYNNRAQCFI MLCREIHGED AAIGQEARRY AMRANMDAAK AIELDPTNGK AYYRRGCAVL
GMAPSASRAK EAMAALETAL SGRASGGKDG IILPNAMRHE VSNLLDYAKR RLDSCTEAAV
PDVESCRENC RQQPRQAKEA GECKKIAWRA SGHPMQCFYL EPLPDVNPHG VYQLRLCHAG
EWIDLVVDDY FPTSQVSEGF TDGQTIRFSR GGNLCYLGDH QRRSAAGSAE ENCANCGRPA
CEHRSLKEWH EHAVTWLRRL RAGRDSGSGP AGLRSLPTRV QHWEPAAAAL WVASGGTFDL
GDHPELAEHE PPGHLVTNEL ISVISVTSQS RHAFHPLLYE NFRRQSYEPR ELVVVDTGSE
PSLFMLERKA DDPRVLYYFF QDEKSARPGS PRLQEEAGAD AMAAVLCSDD PRELTEWGRG
RPHRTEVRRE GWTKGFKRNI ACMMSRGFAL AVFEDGCLTP LGLCSRWNRC SRPANLAHRV
SDEPAARTFR WVDLTSRDPE LDAKPKGEDL EFGFSHVFSR VAWLRQPIPD TEGPHDVQFM
EELEKLGVPI RLVAHGNRLH GISAIGWFRS SAIGAKDAPT NINKYSELVI LACRGHNVPE
PPAAFVPLLP AVEAACKAFV MKRELRLKKM LETEGTMHMC ASCDFAVALQ KHCKDTSTHT
NPYGCTFDIG QFSCAGGAVA EGREYDDGTT WFKGWIWRMA ICRNCGTHLG WRFESRSWNK
SGGRGDAALF WGLIWRHLRE HRAPGEGRAG QSPALHCPQD HPLRRYATPH QHYVCDACGR
QVRAGEHLWG CGACDFDLCE GCRAKVVHRR HEESSVPAES PGRECEGKGR FRVMGGAHTP
GSQQYLRNPN VMLRAIILVL ALPALSASTQ CPERCLANDG TEWPCRFYNS GACMIPVIGN
ASRNASVDVN VVAIGPYSGT IGNMMTMAEP FLLAAAQEIE DSDFLPGYRL NIYLSDSKCT
EQDGTRATIE ALITAPQKHA ILGDSCSQSC NAVNDAARLF NVLTVSPGCD SPGLSDRVRY
PYFTRMSPSD RFKVTAIYEV MQLLGFQRVG VVDGPIYTVG AKDFFLELLQ RDWDRGTYPW
SLLLSRNVQS VPDAESTADE ILMRDSRVNL IVLPEHYGMW LLCQFSLRGM LSPDYVWFVA
AFGNWVNDVT AVFAGTPECP CTSEQLSRVA YGLIISGRSP IQSSPLPHGL SGRRLRDISE
DYLVQCAQFG NGRGACDTVW TGYFYDGLWH LAAILHVYLT VENHSVADLA IESSRQALYD
LSLRQDYLGV TGRVRQFNDV DPVTDPPSYG DRDGVNLLRQ ITGSTGNEFS DLAYRASDGI
QWLADIRWSP TDGTKIVPCR TGSCDMSMAF VPSDRISQCQ AGSVFSVQLG CIECESGKYA
NAGAEACAPC GVGTFANESG MASCHACDKG SFSNVLGADA CELCGRGFYA DNTSSTSCTR
CPLSTYGPEK GLELCSACPA GRSTVFAGAI DVEACQCAGE LWEGRCVQCQ GNTRYEAGQC
VDCQEGLECD GKQSAQLLPG YYSDPSLPFD VYKCLPPEFC PGGDPGECRG GLIGVPCTHC
PTGQAWGADG CRDCTSLSVA GWFVAAVLAM IGIPACYYFL NTKQTAKATT LLATSCVLAM
TISMLQNVGI IGYISFSWPR QLQWLFDLLS IFTLDLQAVG FDCVSHSPVT GYVLIAAALP
SAIIWLVLSS LLSRALPSKF AFESAKLIST MGQFMQVSFT IYSKVALSPM MCYSHPNGKL
GMLEHNGIFC FSSTEHTPMF VTGLLVLAMM TSFYAMTIWA TIKAPSKAAG GNGWFLSATR
FLLFRFRADC WWFGTFMLPR GLLLSLAIVL AGDSPYIQML LIVSTMLLYM IVQLISWPWK
LPALNAFDAI ISASLILMMA ILGAFAPAIA EHTLEQLTSA VIGIVVMLNG IVLIMLGITA
SALIRLNAMG GSQESCLLAL GRVPDPTELT EKLFVLCNKI EELGTAGLSH VLANLSVYDL
RMTQQIVTAV GSEIGEQSLV LTARSQLMST VSVPSTKEPT PPKQTNRGNI KSLSDEVPPL
PKPRSSRGRS LSEEAPASPR RLGAARHEAV ARLLPQASAG GAQGTLELCW ELLAVKPRTD
NLVCQNIGSC MAVAILYRQR RPMHQGARRQ LWPPLVEKAA AKLFGCYGAL KGGTFAEALA
LFTGYPTQRL RLYVPSAVRR EKEEKRQARQ EQRLRLLLGG ADVGDQSREP SIVMTGLRAQ
LELCFRSRFG CGSLGPGQLM GGVFSGPPIV VFDATGTEGN AVVRCLLQHR TRVRAVVPDA
TSFSAQHLEK LGAEVFEHTN DVKGLAEILE GAHGAYCTLN PFSCSARGTQ LAAKRFAAAA
KAANLEHVIW STFEDTCAII PDDSETLPLD KSRCRVPLFD GRGRSDHYFN EAEVPTTFLI
PSFFYESFLD FEALGFLPRR APNGQLFVEL PISRDQPVPL VSAEDVAECA RQIFRKGKDM
LRKYVPVCGD LLTGSQIAGV FSKHLGEEVA FRYLPPAEFR KMHASKSEAL GLMFQYFKDC
NEEACKIRSI SRTQELVAAA RPLHAWFSSG RDHVQALQRN LKIITVFGAT GAQGGALVRA
ILQDPGRAFA VRAVTRDALS KASLALADLG AEVVQCNIDD KEQVKEAMKG AYGAFCITFF
WDHFSPEKEC AHAKIYAEAA AETQVCHVIW STAEDTNGIV PPHDYRIPRI QKKSVVPLFD
GKGRGDAFFQ SLQIPTTFLT PAFYFENLIT FAMGPKLCSG GPGDATFMLP MKTRALPLIA
AADIGLVAYH IFQNSELVGH HVPACGELLT GPEIADHLSS SLGTEVRFKC VDQDEFSSSG
VLAADYWFNA FQYCRDDTDD DEDDDLIWSK LLSCQEAGYL LGAGCSEEGC EKSRTHIVEE
MGLQAPHAYG ILDFAEVTVD GETARLVKIR NPWGQNAPRT WKGKWGKDWS GWTPELQKQL
GVINSSGVLM DDPMSIFWMA FEDVKEYFGQ VEICRVHHDW YEVRQQAWLP SGVGAGQAFD
IMVDERSNVD VAFWQERHLL REGALGAHCT NLDVGLAVLR LRGSDGCDGP LRFELVDAAP
RSFDDCVSLE VILEAGFQYR ILPISLAKLQ DAAPRKGVLA VHSVKRARLT RIESSWKQVA
AGLCHAIKKS GRSWSHPHCA GVKYRHQFEP GGCNFVVENS SPNPIAVQAD AAESMGCSFS
RGEKGIVVRI PPYSQRLVLA LTFSPQAGFS SARIQPQMVP LDMAPEHDSC DVDDVHMPLL
LDGSLSSHDD DLAQAIRLSL TSPQGNTAEA RRLLDKRTKD IFANYRGQGM APNEAASRAA
REDGYKYGIC ADSLVCKEHW LRSFCEEDAE HRQLLHWLLE EGLSRPEDFQ DRVHHAHRLR
ELGNKWYRSD DFRRALHCNL GAIHAVDFTP HEQMDMTDEQ RLAVARELLP VLSNLAQVFL
KRGDFGNVVK AAHLGLRNVN KLPGDEADTF KAKLRYRRAL ALGEPGPEHN LESSLDDLRE
AARLMPTSTE IRSCLHKCKE LLHKDNGGRA ERAQAEAEAA EETQISGHGA DQKPPALSPA
LEMFAKCVGR GLAKLIQCWT CLQKARGGRI SANLWRFGFV ALSSALVMAL THVLFAR
//