ID A0A1Q9DGR2_SYMMI Unreviewed; 2575 AA.
AC A0A1Q9DGR2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=TBC1 domain family member 13 {ECO:0000313|EMBL:OLP94345.1};
GN Name=TBC1D13 {ECO:0000313|EMBL:OLP94345.1};
GN ORFNames=AK812_SmicGene23664 {ECO:0000313|EMBL:OLP94345.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLP94345.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLP94345.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLP94345.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLP94345.1}.
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DR EMBL; LSRX01000547; OLP94345.1; -; Genomic_DNA.
DR OrthoDB; 5472962at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF13418; Kelch_4; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..2575
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013158594"
FT TRANSMEM 2417..2434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2454..2475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2515..2539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1795..2020
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 680..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2293..2366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2293..2354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2575 AA; 284214 MW; 5B58CBA6C82D73DA CRC64;
MHLLLSLAAL QLAACAREDA STVLHAGPPM CCCNPEHRRK TKCFKAEGET LLTDERGQLW
EQLPLEEQVS TKFVCSVSDR TYNMQVLSGA VIQESPESML QEPPGVQAPA VNEVGYTRAQ
SLEEPLNLQE VPIYETKRFA CHRKGKGPTA TDVFCRKGPC PGQTVEAPKC PEDDSYLYKE
ADGHGVCIEE EDLIGDQAKI KMNISILAEI YFPTSAEVII DTNAENNIDL SPKINIDLNE
PMNANFQMRH WESCQNQDVR ISQRTMYSLT QQQKFMLHIV TPRSLGRHGS HTSPWALPRS
DVQHGLPVQV LQVGQQAAAA TFAGTRASSG KALLGGTRGL AAGPPITPRN LRRRLTRFSS
RRPLEEHCTC RVGMVLRCWF SFLVTLNNVK GIFSASRGES HCAVRDDQGT CRQSEDAEEL
VALQAKMEKG PHWGWWARGR FHRGRGYYKV QTTTEAPVQP FWISAAVKTP CNEACGEFND
GLNVFRCGKE AMAAINSTEA IEALVAELGL PNTTCTEEGG SRDGGGSPFT RGPPDNDCYY
WDPTKPASDI DCDDVSVNKR TPLCYCVPAS WQHSLRSRGF RFIFLWLVVP DQGGTGCSMA
SFAIARPFLL LGCIGSPGIH GSFQQDPTGP WFSADRDQTC NDLCTAKNFT ECGKEEMAAI
NSSVALADLL SILNLTCTPP SSPSNRKRNG AGSPFTRGPP DNDCYYWDPT ETASNIDCIS
PAWDEVGERT PAPPAPLPAP KEPNRPIVAS GQYEPGHSVP VARDIAPAAA ELPDELEEPS
AASPPPAPSA LGDSMPTPLE RRQMRQLAAN SSSPSPREAV SEGATPAGTG SAPATCLAAT
ERLRDRLKKR EGSGRTGERT RSVPDASSMV NWQERIELRH KEAEEQQVHE REEKQRTAER
STKRNDALKR VMERREQRQA DAVTLGSEEY SASMSSGGVA AHGNSVRSGL GFRPTAPGHW
FRAWEAPWPM YYSRTWLLAL QAVLPCAQWL APEGLGWQKM DGEPPWKPHT GSIAAPLSDG
TMLLIGGQAG RHGGGHFDCF NCTSDVWQFK HQKAEWIDHS KDVPWDPRWG HSVVTQADDT
VWLFFGCCEK GKPTVMLRDI WSFNPMKGSA WRKIESPPPF EGIQATSAAL TGSDVWFVGG
WSQQRGTLSQ VVVFNLETHL GCTSGVLGKW GSFRVDCWPK EIFVSASGSR VLASAPLGLL
VGAWKIGYQN FNEADHATAI SPDGKWLVMF GGQHAKEGGR KWNRCEDTWR VPLPSAKPSE
WVRLGNLAAA RSSPGVFVLH TGWLMTLGGH WTPETELLSA KGPEDKDGVA KHHEETEFRT
YSDVLALNLN AGSKKWKVVE KEAPWTPRDD VAVGVTTDDT ILIFGGGTLY GGGGYLHDVW
KLEKASAKLG LPLSHAFHRH AELNEALSVT GCLPPGLAQD SVSLVDTLWL GGAYMDVMVR
EERSFEEAWC RRFDIMARTD KDQDILKAFE EDTDAFFDSL LAGESSAPPA KAEPKAAPKA
AEGGFMPPAR IEVPKAAPKA EAPTPEQQPA KAPPAVPKAE VPTVATSVQQ PAKDPPAAPR
AEVPNTLPEA TAAEKMQAPM MPTSERQPQA TPATPAAPRV EAYPQEDKLE ELDATGTSQS
TQEKSERAAM FRMDSSGSEE AEVAHPDYDH SEVHHLTAPP PPADFSTEDI VLHETLEDFY
TQHRQTNMSN INAIVAKYRG HMVPHLWAQL SLKYNLAPLE GLELLSRSLY QSAPFEYREQ
ERQTELEDTL AEVRKLVLAE GLAPSRTVLL ERAMTRGAKD GNDGLLRLLA YRGLPDDQSL
RAKVWKALLG YLPMKRHDEW NAIYGEKRAL YASYRSELLT VSSSQEVSLN VASKSPGSEI
DDQDLLQEIK NDVERTRRDF EYFRRPATKA ALTALLFVYA KLNPGVRYVQ GMNEIAAVLL
YVMSAETDAE TDAFWCFSEM MAEIKDGFMQ ALDHSGEGVY GMVEEISQML RSYDPQLARH
LARAELSLFV FVLRWCTVLF AQDATLPDVL RLWDSFIADP NRYGFVVHVC VAVILGKRDE
LLATDKQFEL AEIMQAGPRG TDFEALLKKA FAICAFERRS LPPQFPPKRN QVIDDFSDWA
QHAAAEAAAV ASEVGADLSK NFQEKVAPAV MERAGQASEV VQDKAQALQS WIQETAPARQ
EAYEQAQVQL SSLWNTVRSR GQQFASEAAT SETAATAAAR LSSAAESASG LFERIKVGKA
LQPLPLPILS LVKCDAIAVP RPCTMALRTR PRRHGHLMSV AAGVIVLCRS LSPDAPLSFD
LLGQKKSTAK QADLEAKQAE LEAKRKEAEE KEHEKQRQKE AEEDAKRKQA EEEEERKRRR
KELIEKETDA VRQAQKAAHR PLNSYEERRI RRQVRSEFLG GGGLQVDDGH KDDWAQPLKP
EMKAQLEDAV RFFSETMRVP AALIGSAALG MLFLPPWKFG WCKDDRPQLE VFEFLYRAYV
ILTAATFCLE LTTVLETSNA HVQLLELGRH GLVLEPTAMD LIMANLEFEY LVCSLSFLCG
VVCFMLSTMC RVLVVFICAD GPLPGERKKW SEEEGLVLVQ PHELVEEAEV GQLVA
//
