ID A0A1Q9DNZ6_SYMMI Unreviewed; 3739 AA.
AC A0A1Q9DNZ6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Phosphatidylinositol 4-phosphate 5-kinase 2 {ECO:0000313|EMBL:OLP96860.1};
GN Name=PIP5K2 {ECO:0000313|EMBL:OLP96860.1};
GN ORFNames=AK812_SmicGene20880 {ECO:0000313|EMBL:OLP96860.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLP96860.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLP96860.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLP96860.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLP96860.1}.
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DR EMBL; LSRX01000453; OLP96860.1; -; Genomic_DNA.
DR OrthoDB; 2909023at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 4.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23084:SF179; OS10G0565000 PROTEIN; 1.
DR PANTHER; PTHR23084; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF02493; MORN; 8.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00054; EFh; 3.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00698; MORN; 8.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00018; EF_HAND_1; 4.
DR PROSITE; PS50222; EF_HAND_2; 3.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Kinase {ECO:0000313|EMBL:OLP96860.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW Transferase {ECO:0000313|EMBL:OLP96860.1}.
FT DOMAIN 225..247
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 248..283
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 294..329
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 3111..3284
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 3360..3514
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3587..3689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3712..3739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3590..3632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3643..3674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3739 AA; 410369 MW; 380C2EC48423B50D CRC64;
MRSHPSAGPQ PRGAGVRFRT PERPVDRPAR GLSPDLCVVG KDAPQRPARG LTSKGGKQVG
RRKPGGAAAS QARPSRNSQT TPSQEKVGHD QALTPDRVST LLQSLGIAAD SVLVDRVLHE
IRHASAGAGR EGQAAAAQAV VGSAEDSNRT RLAPRLPAAS ADSRGRVPGL LEEVLGDFEG
ELDDFRPALP AATSPLRSPE ALLAKLRAVR LKRGLGIAEL QALGDVNGDG RLTAVELGKV
FAAVGINADE ELVYEVWRHI DTNHNGQVSL FELFQAMKPS TTEVLIALSH VKYRRHASLS
TLFRPYDSNG DDKLTPAEFH RMLNDLGFEL DDEGVRDLLQ VIVRDRDGGN LLSLRDLTLA
LESLERQEGR PDLRMGGSSK AGAVESTLPR SPDTLVSHSP KRSLERPKTA PVAGTEAVPS
QESHAESQAQ KASQLAELQN PVVPFRHAIQ RLDPCGLPLG AQAWESLNRI FYRLAQQNKE
VSTRELILAI RSDVRIRTEG LLHRPVIATD DGGPAVSLDE ALHQVETQVL DGIGHLEMVS
WDRFYWLLLE AHRHRATRQI LPVPAVPVRP QSPIPAVKTS PLAWTNCPVD PNDSPAASIQ
WLAQECSCNE EMLYRLYEKF TYCCGGDLVH VPRERFLQAV QNSGSLYAAL MTTPLLSGRP
AVVKPMNWGD VLWQLSRIEA PLLSWSDIVA TVCWCRAWSL GLSESEALHV SPRVRPSSAS
AAKARVEALL QNRAVDATDN RAKASPLQPS IVPKIAHVQD MQSRSPLEMV SRRLAEASGS
GCETRSQRSK HPWLDDSDDD VPSRVSVSRV PAPEIPRLSN EASHSCHSKN QGQAPVALRL
QMPEGRPPPD PKELQRTHEG KGEAAASARQ RWHKPRPHFR SETVVLRMWN EGLDHRDPLA
DSSGGSHRRM AHHELLLRPA PQGLCKLFLC WLAIEGHLNR AYGVSDSDVV GVASHLFGSS
RTSDPAVNRR AAEEYWKAKD LQEAQHRSRL EAEAAGRQLQ LNAPPYDVFT TPPYVNIVVF
DSHDSNCDVN FESPPVTDPL QVGYPADGTA SLRQGNMACG VAPARFVFTT SDLPAYEDMT
VDAKMQIRIT CSEAFFVESL TCENVLDATG DFPRIEGCRF QDHEARLILQ TRLRRQSMYS
LTLKLLLPPG RMTAAQNNYV FTTEFDPMTV IEGTETSIDL GYTVPHAKDD TEYPGSYQTR
GYITGFFYGA WTPTPDGRML ITFGLRTFGF MNTEYNIDVV AYPTNVWKLG TPGTDCEDYG
QPHVGTTCRL RSFQGALASE ANGFRLDVGT TPMNNLGTQG AAEVTLGIPK PPTAVNMYWT
ATSFRIDQDQ LPQEPFTVFS DRPVSVMGTP TGRIAAFERG DVDVEQWEEA GAQPSKLASE
IAPEARPEFN FENGESYIGQ WVGTERHGQG VHRWPNGAKY EGQFERNRAS GQGTFQFPNG
GVYEGQWKAD RAHGHGSYRH FDQASYDGQW RNDKQHGEGV ELWPDGARFE GQHREGQKSG
KGKLLWPDGS SYSGNFEGNA LHGEGVYRWA DGKEYSGQWA KDRMSGAGCF TWPDGRVYTG
QYLDNQKHGH GMMRWPDGGL YEGQWVVLEF KPGNTVMPAT EASGMIVIMP PSTFTIVASA
APQLPSTNYN ELPCTSWPEA DRLAGRWVCP LADSAPFKET TYGVRLKVRN PAEPGAARSW
RIELWEQDAA KPVSATRGIR GMEVSGPMQA ALSQENQLLD SINTVRFDII PSQPIGNVPN
TRLRVLAPPG FFIIKRCLNF MPIELPDAEC IGSDSNSFEL VFSEPGAIQA GVQYSFSLQM
QNPVDYIPDD LNVWSFDTLR PDGVARDTAR SPGFFLYPYA FSSFVVVPLM RKPGPQTVVI
RFVSPLLIPF DDYIRIRAPE GVAWYSADLQ FSTEAALTQA NLLGAQDPTV EFETPNELAV
QLTTTAEANF EYGMAARAEI PQSTPVPNAW WIEQYRRTGL PAPNSWRYIA SQGAAGFKTQ
VLVNTRVDPF NIVAEGWQNP TLFVFETTME VMPFLRATAS GTELIPAMLL VEAPPGFTYI
CPLSPTVYMP TYSISLPSDV TCNVDHNTLA NRNKLFLELP SGVQGDTRYA FTIDVVNARF
IDPLRNFFRL ATMLDGESES KSHAGIPVSH VADAFKGHNT CGAYPVCQPW PRKDLLKPPA
IRAAGSGDEM VPDFAIQNLQ VVEEGQAAGF QLAQRMDNTR YMQFEVREDR VVEATSNVVS
FVIGTTLAVT EPSVLEVRAP IGFIFADACD GLVGWATWIP LMRIGPQMDL CQGMGAADSS
MQHIARVTIS GSWELGDYGL FATVQNPMFT PARNFWGFTI YDSNMLPLMS ESWVFGFQIQ
VVLDPRLKAY NQGNGVDGEA AINYVDISFM LSTRIPPEPS RAHSIVVTAP TGFFFPSICQ
SFTIDTFTPG FIGLPKGTGC EGNNGNVLQV TVPFMRELRN ETYYMFRALV VNPRETFLNV
DSPEKYWRIE SRAGGQDLVD LNRVIPSFAI YPRLRYFAVA ALSQVGLAST TYRIHFRTDQ
SLPPQQTVHI HPPTGTTFGG LTDGTCIDTD PVLLSLQFPT PLISRVTRLP EWVSCRVVSS
TELMLRNEEP ILGGRPLISG PVFEFFVMNA TNAESTPQLN LFQIEAITST AMGKEVWTAP
GWVIYPELTM TSVETANPGY GLYTNFTLTL QTVTEVPSGG SIRIIAPDDY YFGPLIETAD
TRYDPLESEP APQGAGQERP PAQRVTICHI LRTMAWACAL EFTPCVIMDE LDELRTLGMV
LSPSQEDAWR TNRTLCLDMR SKCDPGGRLS DLISCESQGS TLDLYVAPQV FLPSRRIFRF
LIQGYNARNP PTSAAANSWH FMTRNSDSEK TILDEKPQVP GVSLIGIVSV DSIVPSNTKV
SSIENYVTVT LRLATQLAEV QEWACGIFAA PGKARKVARR QAEAAAAVLG GGVGGGFTWP
DSDQATAALA LQLDSGPVKR RATHMLRSGV CQALSWADAG GPGSARCSDR LSNLAVALHS
PTSSIRILCA ASRASAGLWH SLRNGILSRQ AALCASEEEL LAYGRSAERR MSDRDKLAWQ
QWKVSRPDEA SDVSSSAWTL PDSGGQKEIS EFQEPGKMTS LRPYQSEAVA AVQTASPSNC
CVVLPCGAGK TRVGAAITAQ FLNEHPKGCV VVLCLRREGI RQWCRELLQN WDLGALEVGQ
AGAHALRTCR ILLVTYHRML SEKRRSQTPK SLNWEDDGIG EGGALDEDAG GAVAARFRSS
SEALLIADEC HMVPAPKICE LLETLLENKK GRRLVGLTAT LLREGGAGGA GVKGAPEGDV
PWPLLGTCVF RETFTNLAPE YLAPVRCLEI SVPVAGEWRK MFKRQPLAAA VCLSYQKWVV
LEHLLAKHAG ESMLITVERC EQARLLAAMF GIIPLDGSVP ASQMKDYLER FRQRKILALV
ATHVLDDSAD FPELSVMIQM GGHFASRRQE QQRLGRLLRW GPIKRQRWEA TGARPTFYVL
VHQGTIEEKM SRHRTKSVLG VQYECVDASS VTSSPESCLG GGSDFLHPGL TGEKGNDFEK
KHLEVMVKNY RSCLELSQHV AASLPQRTGC QGTRESRLAE IRRWLNGESL ENGMQASPST
ASSKSSSSDG SSDSSGNSSD SSSLSTDSSK RSEANAATKE LAPSKAGRKR KASNIKESAH
SKRDGRDGRG RGRRAPGSKG GGRRTLNSLS VTLRPGIEGM QSEIDLTFAA ATEEKQPEDS
KIFTQIQKSD HSPLAIDLE
//
