ID A0A1Q9E8V3_SYMMI Unreviewed; 697 AA.
AC A0A1Q9E8V3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=tRNA (cytosine(38)-C(5))-methyltransferase {ECO:0000256|ARBA:ARBA00039681};
DE EC=2.1.1.204 {ECO:0000256|ARBA:ARBA00039081};
DE AltName: Full=DNA (cytosine-5)-methyltransferase-like protein 2 {ECO:0000256|ARBA:ARBA00042810};
GN ORFNames=AK812_SmicGene13144 {ECO:0000313|EMBL:OLQ03849.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLQ03849.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLQ03849.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLQ03849.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLQ03849.1}.
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DR EMBL; LSRX01000225; OLQ03849.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q9E8V3; -.
DR OrthoDB; 197881at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR46098; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR46098:SF1; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT REGION 517..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..614
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 697 AA; 78385 MW; F3FC3F5DEDCA060F CRC64;
MLPHSATDRW LTRATPANSR VFRPGRQPAP CEKPTRRWKL LEAGAFVFVT LCRSPGGRRR
ASTPRGRALS RRALRSVFEF FSGVGGMRLS FKDAVPAREP FPTWRAFEVD EACCQAYCEL
YGSKYVTGVR RGELWKNKNQ RGTDELWRCS IDRLPDGAFD GGDLWLMSPP CQPFTRTGKQ
KDIEDPRCKA LLRLLEALPA LAHPPQALLL ENVPEFRGSR AHQHVVSTLS EAGYATEEHL
LSPITFGFPN TRERFYLIAV LAGQDDAAAT AAADLLPDLP TLPGTATARI PVRPVEAFLE
EAAPSETLRV PEKLLEQAYR ENRTLDLAGK GTTLTKTFTS SYGKAEYGGA GLSKTGPLVM
EAPDFPEDGR VQRFQTLEPA RWKFVRYFSP REVASLMGFP DAWELPDALS LRTQWRLIGN
SINVSVVSAL MHRLLVWHSR VGDVEEVLHV ANAENYLGYA RRREEIRAAF EALDPAEKAE
DFDIKTQGVS MKGVSFHPDE PVDASINEVW LWHGTGKEGA HGITDTDFDM GPPLPPHNDD
DDDDNNSKDI DDNNNNNNNN NNNTSNNNNN TSNNNNNNNN NNNNNDHDHD HNDNDSDNKY
DHDDDDDEDD DDNNNNDKNS NINSSSDSNN SNASTNTTTT NTTHRDWKRP SDRKEELEEM
CRTGGYHCIL GDRQKVRGTY REYIVFDNDQ VQMWCFV
//
