ID A0A1Q9EAN7_SYMMI Unreviewed; 1981 AA.
AC A0A1Q9EAN7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Putative serine protease HhoA {ECO:0000313|EMBL:OLQ04473.1};
GN Name=hhoA {ECO:0000313|EMBL:OLQ04473.1};
GN ORFNames=AK812_SmicGene12419 {ECO:0000313|EMBL:OLQ04473.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLQ04473.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLQ04473.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLQ04473.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DeSI family.
CC {ECO:0000256|ARBA:ARBA00008140}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLQ04473.1}.
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DR EMBL; LSRX01000209; OLQ04473.1; -; Genomic_DNA.
DR OrthoDB; 1046951at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00989; PDZ_metalloprotease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.90.1720.30; PPPDE domains; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR InterPro; IPR008580; PPPDE_dom.
DR InterPro; IPR042266; PPPDE_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF129; SERINE PROTEASE HTRA2, MITOCHONDRIAL; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF13202; EF-hand_5; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF05903; Peptidase_C97; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM01179; DUF862; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51858; PPPDE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:OLQ04473.1};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1352..1374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 560..595
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 725..865
FT /note="PPPDE"
FT /evidence="ECO:0000259|PROSITE:PS51858"
FT DOMAIN 1400..1552
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 1468..1524
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1892..1948
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 1981 AA; 216509 MW; DDF7300E2E3DAA9B CRC64;
MKGCQIELVE LDAQKFGRSH DWVLLCADKL GELATAQGDS WRAEAMFRRS YEARLADSQD
AEDTDIANSA YNLAVCLAQQ GKDTVAEQYY RKAVEDQGRL DEAEKLYKEL SQTTALIPLD
SKQRRMAAHG PLELNMPSAD TLQAESSLMM CRTAIQQVVK EHLPKDGLCV VFVETKRGAD
SLEIELHKAL AAFKTGANPI LVATDVAARG QGAPEMIAGP NLWFNLYLTF EHGDEASSLA
LSDGSLDEFL VGCEHSGTAV AFVNERCAYL HDLYDILIEA KQDTPIWFEE MVRQARRPTG
GKGGRRAERF GGLGIASVSA IVSYGIVTVS FVAAGQYAMR CDVPCSGIAD SGLKLVVLSW
QFLCDAETSF RRIFAHPSRL IWAYSLQEEK TLGEPASDQE VLLVLFHAVS ARRLRISVCT
MAPPAILSRG EYLSRLAESR KQCRSGPLMS TQLDCAQHSV PTVPLPRDVF ARAGTSLVSH
TTGTLCRIRG AMDEEDGQED DDDELFLKLP RDSEEEECQL PITLNRDSAL EDDRLPLTLP
KSCESSLEVF LSSDQVALNS VLTNILSKFS ELDADGSGAI TMDELASHWL AAATEVCKRP
LSDSEKELIG GSVQRAFDVM DVEQDGKINK HEWLHTALLD MHPPGPVATE IITQKLRDSD
TPDIVSTLVY TWLSADEMVC GIVTRQMLSI NPCGDAELLD VMNSTGSDSI TYAEFVANVL
RLTFRPVELY YYDLSKSFAS VLSPILLGQY EDGIWHTSVG VFGQELYFFG YILTCYPGQS
AFGQPRKSVQ LGYTLRTVEE LNAEIKRVYF DYRPDLYDAF DHNCNDLSNH MVQFLLGRSI
PDSVRLMSER LKSSSLVKVL RPLLNRMLGN RQSRGKQDGE DKILELEATA RARRNGARRN
SGSAMKLSEP EPEVVSVDSL KLDLEDDEEL RAGVAIAVAG QDATTQQLTG MVLFRSMGAS
APVVAQVEME HPDGTFDIGW FDQAGSKQQA TAVPGASLEP YMPALQASAL LQDVFSKVAG
QVPPSLERWS SMDIGKGDIQ RAAVTCLDGH ALVRSQPSYW SSSVQCRFCL DAIPAGQVRM
HCYSCNYSLC GKCFLQNQNP HVGQNPAGFE EIRHSLAIWP RCDNGHSLER FGGGTADGGA
SCSSCSQPEI GSTGPFFLIC RFCQQQLCHD CSRRSLCTLL DAAYEPRVAR ADAVDSDAVR
RLFAAQGRRK KMKLTSMMLM IQRGGPCGIA TMPLSIADPR KGGVPGVSNH HPDKQGSVSK
ARQVKDNFVN RVAEKCGAAV VRIQTEQKVE IPSIGNADIF SFFFGIKPEI NQQERKIKGQ
GSGFCVDGAV GVVSRSATPL KFDLCWRMEA EVLAAILVSV LLVVLVLLWL LIFFSGFGPT
KLHSWQSRTI RLCKKRKRWS WTKIEEGLFL GSVPRSQDHL IELQGEKVGA IVTLNEAWEL
PVSCASMEEF GMKHLHLPTP DFFAPCLDDI TKAVDFITEC RQQGIGVYVH CNGGRGRSAV
CVLCYLIKTG WPAMKAFQHV KSKRNIANML FLGGRFHKQW RAVLSWQRRE LGGPTRAQGR
KVAPADAVKV LTNAHVVQGA DRILASFPGR RAAIECEILE TDEVIDLAAL RVKDKSQLPL
PSMALGASET VKTGDWTIVL GNPLGLQNTC TLGIVSSLER STGETGFDWM RHPLIQTDAA
VNQGNSGGPM LNEIGEVIGM ISMRALFGEG IGFAIPADSI RTALPSLLAG RKVPRSYIGV
KMAMQDHSGH EAAITLVMTV WASTEQFVDS GLYSDDSCTN RTSGGLFPVG SCTVARTMVT
VEGTEITTIS YATADCSGDQ LGNFTSTDGS CASNRGMYTK NSIFTAASAT VENFGDETCS
GNATSTLTFP VDTCYPLGDT ESLKYQCDGC AVVDVVLDGS PAAEAGVQVG DQILEVGGRK
VRHFDEVQLA VRALPVDNRL KLKVRRGEKS TTLVVTTADI RRLREASPAS PGGRHRVVLL
P
//
