ID A0A1Q9EIT4_SYMMI Unreviewed; 889 AA.
AC A0A1Q9EIT4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Polycystin-2 {ECO:0000313|EMBL:OLQ07278.1};
GN Name=PKD2 {ECO:0000313|EMBL:OLQ07278.1};
GN ORFNames=AK812_SmicGene9371 {ECO:0000313|EMBL:OLQ07278.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLQ07278.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLQ07278.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLQ07278.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLQ07278.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LSRX01000143; OLQ07278.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q9EIT4; -.
DR OMA; SIGMINT; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 436..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 430..631
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 12..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 100742 MW; 8A22B4D107E987FC CRC64;
MPLRVNIAST VASQPGQKGQ PVSPKARVES QHNSKEGTGT ELGIYLAWVK RELDEESACL
ELPFTLLLLI SFSVFALLHL KQHDTFAVEG AWKQELVQNA NFAWAQNFGH KSVYDVNSYA
DFWSWFRIGF LPLAVQHTWA FSEGLNETYE QLQAENMTAF SASQLPATYN LPFGPEPDEA
WAQATLPVPD QFSTFNRIVA GIRLRQERSA ASWDSCKVPD TVSPDLMRAW LGKPCMPADP
PYELTPEAHH AETFREPQRT EWLLSQQKTL KELQLSSLDM EDGCSQLDAK WSALRNTTAD
FSGCACKSCA EGARTLDGQT RPGPWLDEYT QRVELGMVAY NQNHGLISLV SVNFFFNRAG
HVYKLIHVQS AWASWLLGNF LEQVVVVAAD VVWVGSLLFI FISEVRELLG AVRSAKYGIY
QAIFGDYLNF WNMVDWISII CAYAVIGTYL RLIVETGSTT GTMGQYIELA QENLTYAESE
AWSVRVFDAV ETMVLAEADF RFTLSFYPIV VMLRLLKSFD AQPRLSVVTR TLYTATVDIL
HFFIVISCVY LCLALNALMV FGQDMQEFAT LDRALFSSFR AMFGDWDWPS MEKVGAGRLI
ASMWMWTFQI IVVVLLVNML LAIILDAYSE VKSRMSLMTT LDAQISEMLR RRRQSLNKER
VRLSEVWNAY LEKYGDEKLM LSSREIITPE DVMERVQGIG KSQAKRTLAN ARQTWEQSLE
SPYTPDSYME HLKLCGVRLD LLRHKTSYIR AVMSAVAGRI GLTENPTIAL QETTSRAVSM
VKENVKVMSK QVDEVLREEC NALEDRQEDV CSQQKEFTEV SKQTKSKLLD LHQDLHKVAM
SLQEIAASRE IKEQFQRSGM RRIWTGVEAM CAAPTQGTQR QRLLSDSDG
//
