ID A0A1Q9ERN4_SYMMI Unreviewed; 3004 AA.
AC A0A1Q9ERN4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RNase H type-1 domain-containing protein {ECO:0000259|PROSITE:PS50879};
GN ORFNames=AK812_SmicGene6223 {ECO:0000313|EMBL:OLQ10081.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLQ10081.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLQ10081.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLQ10081.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLQ10081.1}.
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DR EMBL; LSRX01000084; OLQ10081.1; -; Genomic_DNA.
DR OrthoDB; 5404203at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001876; Znf_RanBP2.
DR Pfam; PF00075; RNase_H; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..3004
FT /note="RNase H type-1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012525563"
FT DOMAIN 1627..1771
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 20..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1477..1500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..455
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3004 AA; 327031 MW; 1256526CFADCC629 CRC64;
MVWWILVFLV TAETLHHGAV ETPHQRDSGS PTRTESQDRS QNSVTKLLDR TVEYSRPRVL
AACGVLETHH SASLLPGRAR AFLENMTNSW KCTPCRKWNK ANAAFCPHCG KHWEQVAESY
SSTTTSTPWP SRSEQAPWSA QARAWSAPRS PRRPSPRRRG KGKGQANDAA AAKAAGKQAG
KPGGTGKGPT VEMTKPTIEA LPAAPTATSV PAPKAPSHAA GPPSMEKLQL EALVKCLGGL
KETLPPEAVE AIEQLQLSNT QDTTKELHRA VAAQSAAKKQ LIQTRAARAA YIAAWNEYIV
QVSDLIQKQV QEQAAQLAHY DETEMAWRGS LEKATADLAR MANVSTSSAP DEESEMEIAE
AQVDNDIEAA QELERRRQQQ VADSAKLVEV MASLKESAAQ RLAQETSENR EGSRTPRRQK
QGPIDLTKDK EEKPTNAGQP PLPAQQPQPP AKKPPPGSLI VCPCKFCLRE QAAPAMAIYG
GVNSAGFAAA LGRAADVRCI LARQLSISIK GSSSPNNLKD NLCRSTHHRQ SDPALQPVRT
VSSTAVLPSS ISEMATESTL QWATLSQLVR AVPSTALSAE NAEAKAVVAH MDGTLTLSDY
TVKPAPGHFV ELPVAPASKS SPAVRWPSDI SYMRAAAVRI LPGDLDHSQL TWPMPSLPLA
LQSASEETGT SRFTVFEAGS RPRLKACGPD WTLQDIIAEA VANALQPVRA VQLIANPIEG
LPRPQVTLTY LRAPPLALAV PLDFRRTHGW IITVNLEPTD SLRDLPELGP AGTPRPHELT
DQGPLQALMD SSNHRHNSIT VPIDRYEWFV PIFGLRELPP AVALDQSHTT STTTEMRGPN
RRNRSPSPAA SSSSMPPTLL TGTQLAGQTD ECMNSPPQNF RGPVGALVHG TYLEPRSLLR
PRPACPNKPP DRTQQRVPAL HVEPPWAVTC MQQAAPLHTQ DWSGFRTSPD TEGVASLAYY
ALFDVVGHAR IRRAAADWTL SDVFADVLTI LPDTTAIRVL VDRLSGLPVL QVVARPRSAG
PQESPVPVDL RPSGGVICTL LLPAGNTRQH TLVDIAHRCR FQPTSVVTAR GAPFERLPDP
AALVEHLQTR GLEAPASLMQ APSTTVTTTA MMSWAGGAPL PLRHQLTVLT RHGPVHGPVL
QGCQDLPSQL TPLLTHILAH GHAPQRSSIM LARVMPVVYD GVYNVIVLWS QRQSHQVSVV
VDRRLVGGDL DLVETQLGTM PTQVMSADDR RQERHISING VALPIWRRSL RHGDVVQILH
RRISPPVWSA GSTLDFYPEA RGITVPMELL DIEQPPDDLG SDDIDAHNIA SIQCQIEFFL
AGRLNSMGRP GRIMQHVLVQ GPTHGDLLLH LELPTSPSVA QLEDFLLGCD FWDRNLIIYD
TKHVLGPVSI FATTPPNVRA LTALVPSTTV DNLIVVQLDP DRPSLTGHVF WRPHLRPAPV
RTLTQGMFVH LRHIDLPIGE GLQLLQVGAT LRKTNVEHAP ASPSAPPGAD SAKDFHEQAT
PEDCMCRPRV VIPTPGGRRA ITAPAIRSAN TVPALRPGGN TLSCQGPGPQ AVAPPPLDFK
PASRPTLAQT VPLPEPGAAW GVNQDIFEAA FDAYRLPIPD LVPQSQHLLP TARRTWGLLH
PITKYRTLDA VLIYIDGSYD PRARRAGWSF VAVGKQGTEL CRLGALAGLV REPAETVNAF
RAEVWALLQA VAFVVANEFR QVTFAVDCQA ALDVAFGRAQ AATDDPIGLA AQSLLFLARS
KGIHVRPLKV EAHKGIPLNE AADAVAKTAC SRCPPADFNF EDASLRSCID DGSIHRMWLA
TLPSRLSTQL PFVDSRGCWS LPACQLAPST KAATTAVCDA TPSPENWQLH LNIVTYNCLS
ARSRPARALL DAGLQKCHCA LAGFQEARDP DDGISASDHY WIASSACDAS GSFGCQIWIS
KTGEWGRSSA LPLRPVRDSF TLFHTEPRVL VLLLRVGCLK VACVSAHAPT AAAGPEASKT
WWAHLRAVCN RIPPGHTPLF MVDANAAFEH SGRGNTLEST PATENAQQLS QFCVAAELQP
TAQVDRHGHR LVSWTSPDGR TQKLLDYVCV PAAWRTRFHT APNFCLGDLR EGYDHSPIMG
TISATVSAPR PCLKPKYSIE ALRTEAGQQT AAAALASVPA IPWDVDATTH MEIIFGHVQR
FLSHNLPPAP PKPRNPVLSE LSLKLVLARR QVRTIKRRLE HNFGRTLLFQ CFAAWAGRNR
TAQSQARRLL GLSERISRAS FSLTALGKAI GDNFRADRAQ FTRRAMETAR GAGAAEFAHS
IRAILRTGRR FRAPQILHQI SDGASTAACE EDILALLGKH FAKPERARQQ QGRDLLALFD
LVRPPAAKVD MTSLPSVADI ASATMALMRG KAPGMSGLPA ELFQADAFST AELLFPVLAK
SVLRCNGPLQ HNGGLARAIP KSKLQASTPA GWRSILLLEP TGKILQKAYR PQLILALEQH
KSKNQYGGLP RRRLEEPSVM VRAHFARLKA GRQTGGALFI DSRAAYYSLV RDTLIASCTM
QTDEQLRQRA RALFPFRDDQ DGYVQHMKQG GLIQALQLPE PLVRYLESQL GTTWFAMEAP
AHTPYVSGSG TAPGSPIADL LFSFVYARFL RHAEELLLAE GHYVALCAES DPFLMPTWAD
DTAVLIGPAP PSHLTTSLQR VADIVVRGLS GAGLDPNFGP GKTEAVVHFE GAGSRDAKRQ
LLCRSEPGTQ FHSPTCAEQH LRLVPTYVHL GTVVAHNLSE EPNLLHRAQL LQQIFQPLRM
RLLYNGDLTK AEKVRLLEER IFPRFLFGAG LWTPCNSREH DMAVDPLHRA MRQAFRPILG
ISSTGFSNQE VAAALGLPTA EDCLTQARAT TLLHMLRTCS TEVWSGLLMD GHWYQLAWNA
LRKVADEAWP VALCTANPPP PQTLLPLLPA NCSSLCKNYL RVCKKRQPTV ALLPRCADAY
ETPAVTQTAH PALACTCDIC GLSFLDARRL AVHKARKHKQ RAAGFQLAWG TRCECCSTEF
WHVS
//
