ID   A0A1Q9EYT3_SYMMI        Unreviewed;       814 AA.
AC   A0A1Q9EYT3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=THUMP domain-containing protein 3 {ECO:0000313|EMBL:OLQ12608.1};
GN   Name=THUMPD3 {ECO:0000313|EMBL:OLQ12608.1};
GN   ORFNames=AK812_SmicGene3449 {ECO:0000313|EMBL:OLQ12608.1};
OS   Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS   microadriatica).
OC   Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC   Symbiodinium.
OX   NCBI_TaxID=2951 {ECO:0000313|EMBL:OLQ12608.1, ECO:0000313|Proteomes:UP000186817};
RN   [1] {ECO:0000313|EMBL:OLQ12608.1, ECO:0000313|Proteomes:UP000186817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP2467 {ECO:0000313|EMBL:OLQ12608.1,
RC   ECO:0000313|Proteomes:UP000186817};
RA   Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA   Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA   Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT   "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT   adaptations to a symbiotic lifestyle.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OLQ12608.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LSRX01000040; OLQ12608.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Q9EYT3; -.
DR   OrthoDB; 1364859at2759; -.
DR   Proteomes; UP000186817; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.30.2130.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR004114; THUMP_dom.
DR   PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR14911:SF13; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3; 1.
DR   Pfam; PF02926; THUMP; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF143437; THUMP domain-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        537..556
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          184..241
FT                   /note="THUMP"
FT                   /evidence="ECO:0000259|Pfam:PF02926"
FT   DOMAIN          273..407
FT                   /note="UPF0020"
FT                   /evidence="ECO:0000259|Pfam:PF01170"
FT   COILED          750..777
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   814 AA;  89560 MW;  84DC535DB24EF0E8 CRC64;
     MRRTRAAGSV PAMIKTRRLF FERGARYPLR FAMLPLLPAL VRQVQLCCAG AALQRLALPE
     VLADRRKYLL LCTRGLEDQA EALLWRSLGR EVPSWRIPPP QDLPRVSEGH AAVGKLVIGL
     KDDEDFPCGG IPGIIHIYAL VDSARGLSDD KEAAMKQLLT WTAGLGPELL TAVRLTPAST
     ATEATFRASV VRDGEHNFTS EEAMPAVGGG VGMAMPWKVN LKTYDIEVTA IIHRDTVVLG
     LSCAQLGKSR RGATQPSKLP REQRPWHLSD ARHLRFSTAR LLLELAEVSA GDRLLDLCGG
     MGTIALEAAC CFPDLRAVSA DVSQRACQRA EANVAAARSL GLLGLGSSVE VLVRGVSGWT
     RSSQEFDVVV SELPFGVSIS ILDSNVLLTA IQRVVRPGGR VVLIAPCSES PSIEEHTLSD
     TWCEYRRCDG NVGGTSVHIL YFRRADRAIP GKATSNCSEL MALAPEPAAV ERILGGLHEW
     RDVQGVIRTI FQALCDVAHA QSNAVREDIF RTCWRKHSDR EQFGADLEKP ANRGHPLIII
     IIIIVIITTI VIIVIISPRL FMVSFQDLAR QPRIMSICCS RAFLESVRYP DDQASQRIIS
     IVCSQMFVRS VLTDQVFFPS FQKPGQPRII SIVCSQMFVR SVLTDQASQR IISIVCSQMF
     VRSVLTDQVG ELPKTRSVWQ VFTDQASQRI ISIVCSQMLV RSALTDQVER RTGEMQEELI
     AGLGRKADLS DLRDTQATQA EETQCLAETQ RQANEEVQAL RAAIVDLRAA IEKQRADVQQ
     WRAGFEAGLA HEVQAIQQEM KELAASAEVA DSLS
//