ID A0A1Q9F574_SYMMI Unreviewed; 1928 AA.
AC A0A1Q9F574;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=H(+)-exporting diphosphatase {ECO:0000256|ARBA:ARBA00013242};
DE EC=7.1.3.1 {ECO:0000256|ARBA:ARBA00013242};
GN Name=Cyb5d2 {ECO:0000313|EMBL:OLQ14833.1};
GN ORFNames=AK812_SmicGene981 {ECO:0000313|EMBL:OLQ14833.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLQ14833.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLQ14833.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLQ14833.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC {ECO:0000256|ARBA:ARBA00038357}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLQ14833.1}.
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DR EMBL; LSRX01000010; OLQ14833.1; -; Genomic_DNA.
DR OrthoDB; 2872279at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009678; F:diphosphate hydrolysis-driven proton transmembrane transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:InterPro.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR007434; FemAB-like.
DR InterPro; IPR004131; PPase-energised_H-pump.
DR PANTHER; PTHR10281; MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED; 1.
DR PANTHER; PTHR10281:SF4; NEUFERRICIN; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF04339; FemAB_like; 2.
DR Pfam; PF03030; H_PPase; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 453..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1628..1651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1902..1922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1202..1299
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|SMART:SM01117"
FT REGION 1538..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1803..1833
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1553..1567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1928 AA; 216655 MW; 4DCBEDC69DFBE3E7 CRC64;
MQDPELLSPD DSPFLEHQFL SGLEESGCVS LSRGWQPRFL LVAMLARDEE ALLKKHLPAW
KQVGDSFLLG LDSRTQDDSA AVALSLLAPK PLEVYHFDFD GFGSAKSKLL QESHVKFPDM
AYVLVVEPDM MPKRAPFSRE PLRSQEPVYA LRRGGKESLG ERLTDCVFRN DGNWYFRFRV
HETPVYRNAG ERGLPDEIKD TGWSVLELEG SSRDKASRQE RIREELRLVR LDLKDHPGHP
RLMYYLGVLQ YDLAMELSSG GLAPEISEQW LHLGQLKFAI QALMDQHRGA PAMAAAWLYP
GPRVLLLLVG AASAAGHEEA GTAAEPIQLY VDGLPKKTSS DPSCKAHPGC EHLAGNCCPT
WDGLNLGCCF SWHSPLPTPP NYVDVADSSV PGPGGPYRQA IMRDPFSGVL EAETMQPIYL
LPVTNGLKQI VVFFVFGFDL KFKPNSGTWK KKLIKWLASS LFRVIFIGLA ANAFRLDVQK
FLTRNKAESS RYNEVMIAMA VWCISPNFTM GLGIWNQLRL QSPGAVFRDD IAESRYYQLW
TPHIYRDVRF PFCPGGARWL TIAKQVYALV LLPYVIPVMF LEVLMSVLFC YWIVFKSRLL
CLVKCVQVHM ITLGCCLIWL LTAGHYGAEK IHKYWTTLWP FVYMYLVYIF ASFVVPVLMA
VFYGILIGSH WFQIWKGIGL FQESKRKTYG LLHKGARRAL NIAPESGSET SDGEEAPSYI
EEWYYFIMPH RELQLELDDR TLLIRLDENR LSKDFKFNVR EDHTLGVRGV KIVEALLLRL
REQMESDSED DAGLNRGCFD VLVGEETCQD GDINIQNDPT LKHDLQDKKD RKESLHDSEV
QIVMLTIKSL AEAAIVQAVT IFLVRTLTGE TFSDFVNAMN ITIQERHILD WIHHLAKLGE
EKLGKALHTV WSSSREVRQL AAEAQKTLAR RARDSGREGS QEGRQQRSAA AYFCARTYLD
MFSDEKKGEK WLKRTISLEA DFLYARVALI QLLFRQQRHL EAYNEAVASE SLDPPKLRLF
MDSGPLHACD LPLLLSKAIY YMYADAALRP RLLNDGAWPR REILLETCAA RCPAVAGDSL
ARKMQDITKL KACRDNPRSG FQLVGAVPMY LKLHSEGEFC EEADWIEGSL CSMWLGWCTA
ALVAAAAFLI YSLLPFLAPD DVASSESQGS QSSAAARKGK GAAAGAYPRL EAEERILGAR
VWSVAELALH DGQDRNRPLL LAIVGEVYDV GPGARFYSPG EGYAEMAGKD ASRAMSTGKF
DVDAVPSLDG FSDEQVSAVM QWRSFYRHHE EYRFVGFLEG PYYGAEGSHT LELQKLEDTQ
SKTEKVGKTM AEARQRFKAC NSKSKQGEDN TELWCDPGYH GPGTMPVYLT AYNPEAKKRE
SWCACASPAA RSLAHSDDDA PATAPNELVF KFTDYPECKG KMRCWRPKKA GPPTTRKASR
RCEIWHWPRL FVGVPFTPHR GRRLLTAAWL SEEDRAEVQH ELMRGLRAVS DRSKCSMNIA
FATEAENMLL DDDGFILRTA RQAWWMNKQN YNGAYGYVSQ GREDEDSGEE NSAEDTMPER
PERNLASQSH SHAEEVLCFL ASAVGCLVLV EVRPPYGPEE QPVVDAWTMR EINQVFAYRL
PQTVPLALFY SLAGASLGLF TVSYFTSFML LEDQGPKRVV DIGFLISKGV NVYMGRTIPI
APVSERGHAR LMMHSCFALM TGWYAPTPVR SEAQVGVSVT VQGQTRLAHA LGLELFDALQ
IGIRTGSIGG LLATSLALGG MAGMWLLIQD DETIVLATYE TKVSFSMRVG GGIFSKGDME
QTRMEEDQRL FELQKKMAEL DEAEVRVAVE KRKKLRPGYA QKHAMQFWSR VSEVWDKGRI
LGTCTIIGVK GSPVGCSLVA YFVHVHERFT AKRMRWSLRA NLLLVIGLVQ LAAIGLNVWG
FSDKYPDN
//
