ID A0A1Q9J4E0_9FIRM Unreviewed; 325 AA.
AC A0A1Q9J4E0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Sodium:proton exchanger {ECO:0000313|EMBL:OLR39667.1};
GN ORFNames=BIV16_09005 {ECO:0000313|EMBL:OLR39667.1};
OS Roseburia sp. 831b.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1261635 {ECO:0000313|EMBL:OLR39667.1, ECO:0000313|Proteomes:UP000186530};
RN [1] {ECO:0000313|EMBL:OLR39667.1, ECO:0000313|Proteomes:UP000186530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=831b {ECO:0000313|EMBL:OLR39667.1,
RC ECO:0000313|Proteomes:UP000186530};
RX PubMed=27613689;
RA Trachsel J., Bayles D.O., Looft T., Levine U.Y., Allen H.K.;
RT "Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate
RT Transferases and Their Diversity in the Proximal Colon of Swine.";
RL Appl. Environ. Microbiol. 82:6788-6798(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLR39667.1}.
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DR EMBL; MJHW01000006; OLR39667.1; -; Genomic_DNA.
DR RefSeq; WP_075680196.1; NZ_MJHW01000006.1.
DR AlphaFoldDB; A0A1Q9J4E0; -.
DR STRING; 1261635.BIV16_09005; -.
DR OrthoDB; 9794225at2; -.
DR Proteomes; UP000186530; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 1.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846:SF8; INNER MEMBRANE PROTEIN YRBG; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000186530};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..148
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 184..322
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 325 AA; 34600 MW; 6A801B04B2E54A67 CRC64;
MLQIGKAILF LVIGFVFLIK GADFFVEGSS SVAKKLRVPS IIIGLTIVAM GTSLPECAVS
VTASITNNNS LAISNAVGSN IFNLMVVCGF CAVFTPLTVT ASTMKKEFPF SVICALLLLV
LGFFGMTLGH IDGVILIVFF AGFLFWMIKS AQKARSINPE AELDDEIVVD EAEDIKILPV
WRCIIYIIGG AIAIAIGGDL VVDGASVVAA ALGLSQTLIG LTVVALGTSL PELVTSIVAA
KKDEVDMALG NVIGSNIFNI LFVLGIAATI SPVEFITENI IDIVILVAMS ILVWLFAWSK
KKIVRWEGVT MLAIYAAYVV YICIR
//
