ID A0A1Q9JPD2_9FIRM Unreviewed; 366 AA.
AC A0A1Q9JPD2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=MBL fold metallo-hydrolase {ECO:0000313|EMBL:OLR58047.1};
GN ORFNames=BIV20_08210 {ECO:0000313|EMBL:OLR58047.1};
OS Roseburia sp. 499.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1261634 {ECO:0000313|EMBL:OLR58047.1, ECO:0000313|Proteomes:UP000186602};
RN [1] {ECO:0000313|EMBL:OLR58047.1, ECO:0000313|Proteomes:UP000186602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=499 {ECO:0000313|EMBL:OLR58047.1,
RC ECO:0000313|Proteomes:UP000186602};
RX PubMed=27613689;
RA Trachsel J., Bayles D.O., Looft T., Levine U.Y., Allen H.K.;
RT "Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate
RT Transferases and Their Diversity in the Proximal Colon of Swine.";
RL Appl. Environ. Microbiol. 82:6788-6798(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLR58047.1}.
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DR EMBL; MJID01000009; OLR58047.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q9JPD2; -.
DR STRING; 1261634.BIV20_08210; -.
DR Proteomes; UP000186602; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.40.10.10; DNA Methylphosphotriester Repair Domain; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035451; Ada-like_dom_sf.
DR InterPro; IPR004026; Ada_DNA_repair_Zn-bd.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF02805; Ada_Zn_binding; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF57884; Ada DNA repair protein, N-terminal domain (N-Ada 10); 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Hydrolase {ECO:0000313|EMBL:OLR58047.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186602};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 40..234
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 40661 MW; 86A191D6D23725AF CRC64;
MLLLSGCIGQ NQQQSTERTE DSAFTESKEN LEVHFIDVGQ GDATLIRQGE HAMLIDAGDN
SKGTAVQAYL QMQNIEKLDY VIGTHPDSDH IGGLDVILYK FEWDTVMMPD VDKDTRTYED
VIKVIQDKNR QVTVPKAGET YSLGMAEFTI VCPQKNDYGD NSNNYSIGLR LEFGENHFLF
TGDAEEEAEQ DMLASGMDLS ADVFKAAHHG SDTANTEDFL ETVDPDAVVI SCGVENSYGH
PRAAVMNQLR QMGVEVYRTD EQGTIVVYSD GENIIWNCSA SESWKAGEPT VSDAGQETSQ
LQEELQKEPG QEVDNAAYVL NTNTGKFHKP SCSSVEQISE KNREYTNKSR EEMIEAGYEP
CKRCNP
//
