ID A0A1Q9K0M7_9FIRM Unreviewed; 672 AA.
AC A0A1Q9K0M7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=BHF69_04660 {ECO:0000313|EMBL:OLR62032.1};
OS Anaerostipes sp. 992a.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerostipes.
OX NCBI_TaxID=1261637 {ECO:0000313|EMBL:OLR62032.1, ECO:0000313|Proteomes:UP000187371};
RN [1] {ECO:0000313|EMBL:OLR62032.1, ECO:0000313|Proteomes:UP000187371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=992a {ECO:0000313|EMBL:OLR62032.1,
RC ECO:0000313|Proteomes:UP000187371};
RX PubMed=27613689;
RA Trachsel J., Bayles D.O., Looft T., Levine U.Y., Allen H.K.;
RT "Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate
RT Transferases and Their Diversity in the Proximal Colon of Swine.";
RL Appl. Environ. Microbiol. 82:6788-6798(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLR62032.1}.
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DR EMBL; MJIG01000004; OLR62032.1; -; Genomic_DNA.
DR RefSeq; WP_075669928.1; NZ_MJIG01000004.1.
DR AlphaFoldDB; A0A1Q9K0M7; -.
DR STRING; 1261637.BHF69_04660; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000187371; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OLR62032.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000187371};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 8..143
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 672 AA; 77081 MW; AC387FD48AC4251E CRC64;
MKAVTYVKSL FITEKPSVAR EFAKALKLNT TNKDGYMESN NTIITWCVGH LISMSYPEKY
DPALKRWDLA TLPFLPKEYK YEVIPSVKKQ YEIVSSLLHR EDVDTIYVCT DSGREGEYIY
RLVAQMAQVE GKQQKRVWID SQTEEEVRRG IKEAKDLSEY DHLAASAYLR AKEDYLMGIN
FSRVLTLKYG WTISNYMKQK KNTVVAVGRV MTCVLGMIVQ REREIRTFVP TPFYRILGDF
MLGEEKIEME WRVTQDSQYY GSPYLYKENG LKEERYAKQL IDYMVKEPPV TGKVCSISRK
KEKKYAPLLF NLAELQNTCS KMFKISPDQT LKVVQELYEK KLVTYPRTDA RVLSTAVAKE
IYKNINGLTG YTPLASFASE ILEKKQYQGL AKSRYVNDKQ ITDHYAIIPT GQGLGTLRSL
NQLSASIYMV IVRRFLSIFY PPAVYQKINL ETLVLTEHFF TSTKVLLEEG YQKVANAGLE
KKEEGNPHLA EVLSAVRKGK QLPVREFHIK EGTTTPPKRY NSGSMVLAME NAGQLIEDEE
LRAQIKGSGI GTSATRAEII KKLVNNKYIA LNKKTQILTP TQVGEMIYDV VYASIRSLLN
PKLTASWEKG LTYVSEGAVT EEEYMQKLEK FITDRTNAVR CLNNQSVLQQ SFDYAAQYYK
KKGKKENETV KK
//