ID A0A1Q9LC58_9PSEU Unreviewed; 357 AA.
AC A0A1Q9LC58;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA {ECO:0000313|EMBL:OLR89596.1};
GN ORFNames=BJP25_05900 {ECO:0000313|EMBL:OLR89596.1};
OS Actinokineospora bangkokensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=1193682 {ECO:0000313|EMBL:OLR89596.1, ECO:0000313|Proteomes:UP000186040};
RN [1] {ECO:0000313|EMBL:OLR89596.1, ECO:0000313|Proteomes:UP000186040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=44EHW {ECO:0000313|EMBL:OLR89596.1,
RC ECO:0000313|Proteomes:UP000186040};
RA Greule A., Intra B., Flemming S., Rommel M.G., Panbangred W., Bechthold A.;
RT "The Draft Genome Sequence of Actinokineospora bangkokensis 44EHWT reveals
RT the biosynthetic pathway of antifungal compounds Thailandins with unusual
RT extender unit butylmalonyl-CoA.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLR89596.1}.
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DR EMBL; MKQR01000032; OLR89596.1; -; Genomic_DNA.
DR RefSeq; WP_075978779.1; NZ_MKQR01000032.1.
DR AlphaFoldDB; A0A1Q9LC58; -.
DR STRING; 1193682.BJP25_05900; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000186040; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:OLR89596.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186040};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 8..238
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 314..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 37994 MW; 069E70BA491FA054 CRC64;
MGSSDLAVVA EGLRKRYGDK VALDGFDLEV RAGTVCGLLG PNGAGKTTAV RILSTLQRFD
GGRATVAGHD VATEAAKVRY RIGLVGQNAA VDEVLGGKQN LVMFGKLYRL GAAAARQRAD
ELLERFGLAE VGDKPVKSYS GGMRRRLDLA ASMILAPAVL FLDEPTVGLD PRGRNEVWEA
VRDLVRQGTT VLLTTQYLDE ADQLADRVSV IDTGRVIAEG TPDQLKTKTG GDRIDLAVPD
RDQLALAART LEQLVGAAPE LDEEDRKLSV RVANSDASLI EVVRALDAAG VSAEDIALRR
PTLDEVFLHL TGRRPVSEEE AAAAAKAAKA DKKSKPDRKG KKDVPAAERA GAQEVNA
//
