ID A0A1Q9LM34_9PSEU Unreviewed; 5166 AA.
AC A0A1Q9LM34;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=BJP25_19180 {ECO:0000313|EMBL:OLR93075.1};
OS Actinokineospora bangkokensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=1193682 {ECO:0000313|EMBL:OLR93075.1, ECO:0000313|Proteomes:UP000186040};
RN [1] {ECO:0000313|EMBL:OLR93075.1, ECO:0000313|Proteomes:UP000186040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=44EHW {ECO:0000313|EMBL:OLR93075.1,
RC ECO:0000313|Proteomes:UP000186040};
RA Greule A., Intra B., Flemming S., Rommel M.G., Panbangred W., Bechthold A.;
RT "The Draft Genome Sequence of Actinokineospora bangkokensis 44EHWT reveals
RT the biosynthetic pathway of antifungal compounds Thailandins with unusual
RT extender unit butylmalonyl-CoA.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLR93075.1}.
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DR EMBL; MKQR01000013; OLR93075.1; -; Genomic_DNA.
DR RefSeq; WP_075975342.1; NZ_MKQR01000013.1.
DR STRING; 1193682.BJP25_19180; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000186040; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 7.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 7.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 14.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186040}.
FT DOMAIN 931..1005
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2288..2362
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3718..3793
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4753..4828
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 5166 AA; 547332 MW; 2E09AABB8702F4B3 CRC64;
MGTGLPLTGA QAGVWYAQQA EPDATEFHIA AAVDLRGPVD VARLAAALGA TLAEAEGLHV
RVVVEGGVPR QVPVPPPTGP VEVVDLRAEA DPGSAALAWQ LADRVRPIDL AAGPLHRNAL
LVLADDHVRW AMRFHHLVID AVGIAMLAAR VAARCTGRDP GPVDWSLARL VREEGEYLAG
EQHAADRAFW ERRLAGAPEP VRLLDRSPAP PTRLARRDVL VDAAPLHAAA ARCGTRASRL
LVAAAVGYAH RVSGATDLVL GLPTAGRTSW DVPGMTSNVA PLRVAVDPHA PLSHLVAAVV
AEVASTTRHG RHRAEEFARA HGLDGVDALV GPTVNVVGFL RDLDFGDLVP DLRTVWPGPV
HDLAISAVEQ PGGTAYRLTL EGDAAVCGQP ELAAHERGLR AVLDALVATP DLPLRAVELA
ELPPGLGTDP VEVDEVTWPG LVVRQAARTP EAVAVVCEDV RLTYAELDVA ANRVAHLLAA
HGVGRGDVVG VALPRSVELV VALLGVMKAG AAYLPLDLDH PAERIAHMLT DSAARLVLTT
AALAADLPPT ERIALDEVDP AGLSAADPGV PLTLDDAAYV IYTSGSTGKP KGVVVTHDGI
GSLIATAVER LGVSAESRVA QFASVGFDVA VWDLVMALGT GARVVVVPEH RRVAGPQLTD
YLAEQGATHM ILPPSLVTAL PEECALPAGA VLVVGTESVP AELVARWTPT LRVVVAYGLT
EATVNSTLWA ARPGWRGQVP IGGPDPNTRL YVLDPVLRPV GIGVAGELYV GGRGLARGYL
GRPGLSAARF VADPFAGPGE RMYRTGDRVR WTAAGDLEFL GRADNQVKIR GHRVEPGEVE
SVLLRQPKIA QASVQLRRDH RGAPRLVAYL SGTGVDVATL RAAVDAELPA HMVPSVFLPL
DGPLPLTPNG KLDTRALPDP DWAGLAGVGS APRTDAERAL AAVYADVLNL PEVGTRDGFF
ELGGDSIVAI QLVSRARAAG YAITTRDVFR HRTVEALAAV ATPTTAARAT DDGTGTVPTT
PVVRWLSRVD GPVDAYHQAV DLPLAAEVDA VALVRRLLDH HDMLRARLND DWTFEVPPPG
TVDPVVLSPS DVDPVSLLAP REGRVLVAVR HPGGLSLVAH HLVVDGVSWR IIAEDVARLA
AGQEPLPGTT SFRRWATELT TVDRSGERAF WQRQLDGPDP LLGTRPLTAA DTAATARTHE
LTLPPEVATP LLGRVPAAFH GSAADVLLTG LVRAIGRWRG TGGAVLVELE GHGREEQVVG
DVDLSRTVGW FTTTYPLRLD PGAGDLAAAV KRVKEQVRAV PDHGIGAGLL DLPAGRPQVL
FNYLGRLDAP LRAGVDPAMP LGHAVEVNAA AVDTPAGPTL TAALSWPAGV FAADRVPALA
ALWADELRAL AALDSGGHTP SDFPLAGLTQ SEVDELGHVV DVLPVTPLQA GFYFHEAFDA
AETDVYAVQQ VVELRAPLDP EAAHRAAQEV LDRHAPLRAS FHQLADGRVV QAVRAGVEVP
WLATDDDPAE VARAQREARF DLAAAPVLRV ALVRGRWLVL TLHHIATDGW SAPILVRELL
DRCAGVALDP VTPLRDYHEW LARQDADEAL VAWRSALDGA EPTLLGSAAA AGAPQRLELS
LPQAGVDAAA RGLGVTTSTL VQTAWAVVLG RLTGREDVVF GTTVSGRSSA VPGIESMIGL
FANTLPVRVR WRSTDTVGEV AARTQAEQAE LSAHHHVALA DLQRGTGPLF DTLVVFENYP
LDALPDVVGF EHSGGGHYPL ALIVLPGDEL RVQLEYDPAR IPGAAAIGAQ FLAALRAEVD
RPVARVSLSD AAPLVGADPV TAPEGVVTAF ARQAAATPGA TAVIGAQRLT YAELDRWSAQ
VAAGLDIAAE DVVAVLAPRS VEQVVGLLGV LRAGGVHLPV DPAYPPQRRA LLREDSGARA
VLTTDDIRAA RTRVPAPAVD TDPAQGAYLI YTSGSTGRPK GVLVPHSALA SQLAWLRAEL
PLAADDRVLH QISPSFDPAM VEVLWPLTSG AAVVVAEDNG DAEALVATIR EHGVTTAVAV
SSLLEALLSS DVDGLRGLRR VLGGGEAMGG EFAARWRAAT GGELVNVYGP TETTVQATWW
PATASSGPVP IGRPVDRTRA YVLDHYLRPA TTGELYLAGA QLARGYHGRP GLSAERFVAD
PFGAPGSRMY RTGDLVRRDG DALVYLGRAD QQVKVRGHRV ELGEVEAHLR AHGEAAAVLD
DSGPSARLLA YVVTTDPEGV RAALARDLPP ALVPDEVIAL GALPRTPNGK LDRAALPAPT
RAARTAAPAG AGAAAVLADI FAAVLKLDSV GADEDFFALG GDSILSITAS SRARQAGIDV
SPKDVFERRT PAALAAAAAP AGPPARSADD GVGDVPLLPV VHHLRERGGP VDGFTLSMLV
QTPAGATAEQ ITRTLQAVVD HHDGLRVQLT RVASVLWSLR TNAPGAPVVV ERVDGFDGVE
PGLSPETGRV LRFLWRDGGA GPGKLLVLAH HLAVDGVSWR VLFDDLAAAW AGTPLPPVPT
SLRRFAQHVT GQAQAADRLA ELEHWARALA PGAELRPGLR PGTVAGLRAH VVELPVADAR
AVPDDVLLAA LRVAVTRWRG GADLVVDVER HGRPDELDLS RTVGWLTSFH PVRLPAADEP
AEQLGLVRAA LAAVPGDGLG YGILRYLNAQ TAPLLAQLPP AQVLFNHFGR FPEARAEDWL
PAPDAPVLLP DADLGMSHAL QVDTVCAETA AGARLRATFS WACELTEDEV RELAGHWAAA
VGELVGRPAA EVWPLSPLQE GLYFHATYDT TGLDVYTAQS TLDFDRRLDL DALRAACATL
LARNPSLRAG FEDRPGGPVQ VISADAAVAV EVVDVATRAD AADLMAADRA VRFDLSAAPL
VRMLVLRFPD GTDRLVTTHH LILWDGWSEG RFLEQLLSLY ERGGDDRGMP EPGSYRDYLD
WLDRQDADAA RDAWRAALSG LAEPTLLGRA DTALSPVAPR RHLTELDRDR VQAAARAAGV
TLNTLLNAAW ALVLSAATGR GDVVFGTTVA GRPTEVPGVE SALGMFLNTV PVRVDLDPAE
PVALLLRRIQ DQRTALMPHE YLGLGELQQV AGHPRLFDTL YVLQNFLDAD AFTALRDRFG
VTPAGSADAT HYPLTLVITP AETLRVKLEY RPDVLDDATA RAHLDRFTAV VDALAADPHA
PVGALDLLLP AEHADLAAQR TATAHDVPDD TIADLLAERA ALVPDEVALV FGDQRLTYAQ
LDARVNQLAR HLLARGAMPE AVVALALPRS AEMVVALFAV LRTGAAYLPL DLDHPVDRLL
MMVADTGSVC LLSMSTVDER LSAGAVLLDD PTLRAELDTT PDHPVADSER PLFARGVPGR
LEHPAYVIYT SGSTGRPKGV VTPYRGLTNM QLNHRAEIFD PVVAAAGRRL RIAHTVSFAF
DMSWEELLWL VEGHEVHVCD EQLRRDATAL VAYCAEHRID VVNVTPTYAQ LLFEEGLLDG
HVPPLVLLGG EAVPDAVWTR LRDTPGTSGY NLYGPTEYTI NTLGASTADS PTPVVGKPIW
NTRAHVLDAR LRPVPPGTPG ELYIAGIGLA RGYHARSALT AARFVADPFG APGERMYRTG
DLVRQRPDGN LDFLGRTDDQ VKIRGYRVEL GEVEAAIAAH PGVRHAAVVA TEHGGAKRLL
AYVVGGVDGL REHLKRRLPD YMVPAAITAV DHLPLTVNGK LDVRALPVPD LAAGSGRAPS
TPTERALVEL FAAVLGRTAV GADDDFFELG GHSLLATRLI SRVRADLGAD LAIRDLFEAP
TAAGLAARVD SAGAATRPPL VPVARPALLP LSHAQQRLWV LQQFEGASSA YNFPLVFRVD
GALDVDAWRA ALTDVSDRHE ALRTVFVEHG GEPHQVILPA GTVPVVEVLP HHDGLVQEAV
DRPFDLSTEP PLRCTLSKPS ADSTLVVILL HHITTDEWSD RPFLRDLTEA YAARLRGLPP
RFEPLPVQYA DYALWHRALL DSGVAARQLD HWERVLDGVP QELDLPTDRA RPARPSFRGG
AHQLTVPPAT ATGLRELSAR TGASTFMLLH AAVAALLHRL GAGSDIPLGA PIAGRVDAAL
DDLVGFFVNT LVLRTPVRGA MSFTELVAVV REVDLAAFSH ADVPFESVVE RVNPARAVGR
NPLFQVMVGH HAGTDAVPLP GATATPVGFA TTTAKFDLVF SFAEHAGTGR LDCTLEYATD
LFDHDTAVRL GERLTALLAA VVADPGARLD SVDLLTADER EQVLVGFNDT DREVPELTMP
ELFARVVERK PDAPAVVDRG VVWTYAELEA RSNRIARLLL DRGVGPEDVV GLAIPRSAEM
AAASLAVVKV GAAYLPLDLT HPSDRLAYML DDAGARVVLS TPAAAGSVPA EVVLLDDLPT
DDSPVGSGPA TLASTAYVIY TSGSTGRPKG VLVPHDGIAS LAATAVDRMG LREDSRVLQY
ASVGFDVAVF ELTMAVCVGG TLVVAPDEVR TAGRELTDFL AEQRVTHLIL PPSLVAALPE
GCELPEGATI LVGTETVPPD LIARFAGRLH VLAAYGLTEA TVNSTLWPAE PDWPGTVPIG
APDPNTRVRV LDEALRPVPP GVVGELYVTG RGLARGYLGK PGLTASRFVA DPFGAPGERV
YRTGDRARWR RDGTLDFFGR VDDQVKIRGV RVEPGEVEAV LAAHPAVRQA VVVVDRGGVS
PRLVAYAVVA EAGVREAGGG LDLRAHAAAA LPEHMVPSAV VLLDGALPLT PNGKVDKRAL
PPVDWAALAG DDKPATELEA RVAAVFAAVL SLPAVGAHDN FFALGGHSMA AMRLVGALRG
EFGVDVSVRE VFEAPTVVGL AGVLAGATAG RPPLTRRSGP AVEAPVRAQW LDRPGDDHHF
VLRMDSPPAL AAAVDDVAAR HGLSAPGFVA EWDGDALALR MRYSSVDEWS VVPLFRDLRT
AYEARVAGQE PGFTDLPVSY ADYAAWSAEV LAPVRDEQLA FWRRRLDGVR WQVEPSDPAA
DFVPLVLGAD LRAAVDELAE STGTSMFMVL QAAFATCLQE FGEGPDLPLG TLVAGREDAQ
LADLVGCFFN TVVLRTRVLP DFRDTLSRVR VDNLDALDNR LLPYSDLASA PPRLMVVHHE
QAALDGTGVT VVPVGVSASD LSLAFYQSPV GHPVHCYLHY RTGVYDRSTV ESVAAALVST
LEENAR
//
