GenomeNet

Database: UniProt
Entry: A0A1Q9NKC6_9ARCH
LinkDB: A0A1Q9NKC6_9ARCH
Original site: A0A1Q9NKC6_9ARCH 
ID   A0A1Q9NKC6_9ARCH        Unreviewed;       836 AA.
AC   A0A1Q9NKC6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   10-APR-2019, entry version 9.
DE   SubName: Full=Bifunctional aspartokinase/homoserine dehydrogenase 1 {ECO:0000313|EMBL:OLS22548.1};
GN   Name=thrA {ECO:0000313|EMBL:OLS22548.1};
GN   ORFNames=HeimC2_29220 {ECO:0000313|EMBL:OLS22548.1};
OS   Candidatus Heimdallarchaeota archaeon LC_2.
OC   Archaea; Asgard group; Candidatus Heimdallarchaeota.
OX   NCBI_TaxID=1841597 {ECO:0000313|EMBL:OLS22548.1, ECO:0000313|Proteomes:UP000186209};
RN   [1] {ECO:0000313|EMBL:OLS22548.1, ECO:0000313|Proteomes:UP000186209}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LC_2 {ECO:0000313|EMBL:OLS22548.1};
RX   PubMed=28077874; DOI=10.1038/nature21031;
RA   Zaremba-Niedzwiedzka K., Caceres E.F., Saw J.H., Backstrom D.,
RA   Juzokaite L., Vancaester E., Seitz K.W., Anantharaman K.,
RA   Starnawski P., Kjeldsen K.U., Scott M.B., Nunoura T., Banfield J.F.,
RA   Schramm A., Baker B.J., Spang A., Ettema T.J.G.;
RT   "Asgard archaea illuminate the origin of eukaryotic cellular
RT   complexity.";
RL   Nature 541:353-358(2017).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OLS22548.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; MDVR01000074; OLS22548.1; -; Genomic_DNA.
DR   Proteomes; UP000186209; Unassembled WGS sequence.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:InterPro.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009067; P:aspartate family amino acid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001341; Asp_kinase.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR011147; Bifunc_aspartokin/hSer_DH.
DR   InterPro; IPR027795; CASTOR_ACT_dom.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF13840; ACT_7; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000727; ThrA; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS51671; ACT; 2.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000186209};
KW   Kinase {ECO:0000313|EMBL:OLS22548.1};
KW   Transferase {ECO:0000313|EMBL:OLS22548.1}.
FT   DOMAIN      328    403       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   DOMAIN      409    486       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   COILED      489    509       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   836 AA;  92250 MW;  999098321A9D5F35 CRC64;
     MNWVVHKFGG SSIRDENQFE HVAKLITDTL IEPNETQIAI VLSAIGGVTD QLIELLDLAK
     QKDENYLSNF EKLKSLHMDR VSSLLADSPN KKSIEAGINT DFNDLSDILR TVRITKSYSS
     QILDLVSGLG EIWSTNIMAG LLEKLGRTPL WIDSRRIIIS ETLLTGPSID WRQSKKNLEK
     ELEEVSKYNL LVIPGFVAST NEGIVTTLKR NGSDLSAAIM AVLLDAESIH IWTDVNGMYS
     ADPRRVPDAV ILNDISYLEA LELAYFGAEV LHPSTIAPAI EKNISITIHN TFNHEHPGTR
     IYQLSDDTSN QTLVKGFATV DSIALITIEG AGMIGVPGIS KKLFGALSSA EVSVMMISQA
     SSEYSICVAV TEFDGSKAQK AVEKEFAMEI SQGHIHAVKL EKNVGILAAI GDQMVHQPGI
     ASIFFSGLSR SRINVRMISQ GSSERNISVI IDSNDMTRAL RAVHSAFYLS HLTLSVGIIG
     IGLIGSSLLD QIQNQIEKLK NQYNIDLRIN GLANSTSMLL MKQIQLQNWK SEFENQSRKM
     DIAEFTDFVH TDSIPHSVII DCTSSESIAN MYDQWLKRGI HVITPNKKAN SSKFEQYSNL
     QNYILKGPST NPLDKTTHYF YETTVGAGLP IISTLKDLIK TGDQIDEIEG VLSGTLSFIF
     NNLSEIKSFS EVVKIAKREG YTEPDPRDDL SGIDIARKLV ILAREIGLKI NVEDVKIQSL
     LPDSLFDDSS VEDFLNKLPE YDSNMAEKVS QASNENKVLR YVGVIRASGE CFIELKPYPN
     NHPFANLRGS ENIILFKTMR YKTYPLIVQG PGAGAAVTSA GVFAELLRLA DLLGNS
//
DBGET integrated database retrieval system