ID A0A1Q9RUN3_9PSEU Unreviewed; 798 AA.
AC A0A1Q9RUN3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:OLS99536.1};
GN ORFNames=BJF90_08575 {ECO:0000313|EMBL:OLS99536.1};
OS Pseudonocardia sp. CNS-004.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1904967 {ECO:0000313|EMBL:OLS99536.1, ECO:0000313|Proteomes:UP000186863};
RN [1] {ECO:0000313|EMBL:OLS99536.1, ECO:0000313|Proteomes:UP000186863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNS-004 {ECO:0000313|EMBL:OLS99536.1,
RC ECO:0000313|Proteomes:UP000186863};
RX PubMed=27902408; DOI=10.1099/mic.0.000386;
RA Schorn M.A., Alanjary M.M., Aguinaldo K., Korobeynikov A., Podell S.,
RA Patin N., Lincecum T., Jensen P.R., Ziemert N., Moore B.S.;
RT "Sequencing rare marine actinomycete genomes reveals high density of unique
RT natural product biosynthetic gene clusters.";
RL Microbiology 162:2075-2086(2016).
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254, ECO:0000256|RuleBase:RU003707}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLS99536.1}.
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DR EMBL; MKJV01000123; OLS99536.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q9RUN3; -.
DR Proteomes; UP000186863; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 2.40.50.840; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.12.10; Lyase 2-enoyl-coa Hydratase, Chain A, domain 2; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR040771; TLP1_add_C.
DR PANTHER; PTHR11941:SF165; CARNITINYL-COA DEHYDRATASE; 1.
DR PANTHER; PTHR11941; ENOYL-COA HYDRATASE-RELATED; 1.
DR Pfam; PF00378; ECH_1; 1.
DR Pfam; PF18313; TLP1_add_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Reference proteome {ECO:0000313|Proteomes:UP000186863};
KW Transferase {ECO:0000313|EMBL:OLS99536.1}.
FT DOMAIN 432..509
FT /note="Thiolase-like protein type 1 additional C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18313"
SQ SEQUENCE 798 AA; 84332 MW; 63F757E564AB45E9 CRC64;
MGASPMTSAV LDPRTPVLIG VGQASERVDA EAYRGRSPVE LAADAARAAL TDTGAEPAAV
AAVIDTVAGI RQFEISTPGA RAPLGRSDNY PRSVAHRIGA APGRAILEVT GGQGPQHLVT
ELAGTIAAGG CEAALLFGSE AISTARHLAD APDRPDFAEH VDGDLEDRGY GLRGLITRQQ
TTHGLTGAPV QYALLENARR ARLEQSREEY ARGMGELFAP FTRVAADNPH AAAPIARDAV
ELVTVTERNR MIADPYPRYL VARDQVNQGA AVVLTSVAVA ERLGVPRDRW VFLHGHADVR
ERSLLERADL SVYPAAVLAT THALEVAGIG LADVATFDLY SCFPIAVSTV ADGLGITPDD
PRGLTLTGGL PYFGGAGNNY SMHAIAETVQ HMRDRPGTYG VVGANGGILS KYSVGIYSTT
PTPWRTDASD RLQTEIDAWP APEPAVHADG EATIETWTVS YGRDGARTGI VVGRLEADDR
RFLAQVVEGD DELLDLLATG DPVGTRVYAR SFGIGNRVAT GRGRMDALRP PRPAAFRTGP
AGYEHVLVHR EGHLLEVTIN RPESRNSLHP PANEELDEVF DAYFADPDLW VAIITGNGDK
AFSAGNDLIW TASGKPLWVP KNGFAGLTRR PAMTKPVIAA VNGFAMGGGC EIALACHLIV
ADETARFALS EVRVGLVAGE GGLARLPRAL PRALATEMIL TGRRLTAQEA CAHGMVSRVV
PAGTALAGAR ELAAEILASS PTSVRTSLQI MAETDGIPDT VEAAAHPSTA LDDLLVSADM
AEGVAAFAEK RPPRWHNR
//
