ID A0A1Q9TK92_9ACTN Unreviewed; 331 AA.
AC A0A1Q9TK92;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=BJF83_22670 {ECO:0000313|EMBL:OLT25790.1};
OS Nocardiopsis sp. CNR-923.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1904965 {ECO:0000313|EMBL:OLT25790.1, ECO:0000313|Proteomes:UP000185703};
RN [1] {ECO:0000313|EMBL:OLT25790.1, ECO:0000313|Proteomes:UP000185703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNR-923 {ECO:0000313|EMBL:OLT25790.1,
RC ECO:0000313|Proteomes:UP000185703};
RX PubMed=27902408; DOI=10.1099/mic.0.000386;
RA Schorn M.A., Alanjary M.M., Aguinaldo K., Korobeynikov A., Podell S.,
RA Patin N., Lincecum T., Jensen P.R., Ziemert N., Moore B.S.;
RT "Sequencing rare marine actinomycete genomes reveals high density of unique
RT natural product biosynthetic gene clusters.";
RL Microbiology 162:2075-2086(2016).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLT25790.1}.
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DR EMBL; MKKC01000118; OLT25790.1; -; Genomic_DNA.
DR RefSeq; WP_075927679.1; NZ_MKKC01000118.1.
DR AlphaFoldDB; A0A1Q9TK92; -.
DR STRING; 1904965.BJF83_22670; -.
DR OrthoDB; 9763993at2; -.
DR Proteomes; UP000185703; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21109; SPASM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017200; PqqE-like.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR PIRSF; PIRSF037420; PQQ_syn_pqqE; 2.
DR SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000185703};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 17..222
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 331 AA; 36274 MW; DC29DD66AD998494 CRC64;
MSVISQEDTD EHRSSSVGVP ELVYFNLFDD CNVRCNMCEC WKRPRSAKSA EDFVEVLDQV
LARRPRAIRF TGGEPLLLRG LPDLVRRGAE SGARVSVITN GRLLTSKARR LADAGCTEIV
ISLDGVGTTH DRIRRNRGLF DKCLAGIDAA TTAGMSYGVN TVVQRMGVED LQTLADLLLS
RALPPRWWHL IPVRDHDDLV PTAEQRSHLR RLIPALIDRA AEHGVDVIAE PDMFGEQRPA
PCTVPAFTAY VRADSGEVYG CNMLAYADGV IADVREGSAS GHWGGSRAED LRARCAEGTN
TACSRCDPAS RTMNHFLRHL AADHALEGAS R
//
