ID A0A1Q9TPT7_9ACTN Unreviewed; 780 AA.
AC A0A1Q9TPT7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:OLT27486.1};
GN ORFNames=BJF83_02615 {ECO:0000313|EMBL:OLT27486.1};
OS Nocardiopsis sp. CNR-923.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1904965 {ECO:0000313|EMBL:OLT27486.1, ECO:0000313|Proteomes:UP000185703};
RN [1] {ECO:0000313|EMBL:OLT27486.1, ECO:0000313|Proteomes:UP000185703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNR-923 {ECO:0000313|EMBL:OLT27486.1,
RC ECO:0000313|Proteomes:UP000185703};
RX PubMed=27902408; DOI=10.1099/mic.0.000386;
RA Schorn M.A., Alanjary M.M., Aguinaldo K., Korobeynikov A., Podell S.,
RA Patin N., Lincecum T., Jensen P.R., Ziemert N., Moore B.S.;
RT "Sequencing rare marine actinomycete genomes reveals high density of unique
RT natural product biosynthetic gene clusters.";
RL Microbiology 162:2075-2086(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLT27486.1}.
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DR EMBL; MKKC01000087; OLT27486.1; -; Genomic_DNA.
DR RefSeq; WP_075926761.1; NZ_MKKC01000087.1.
DR AlphaFoldDB; A0A1Q9TPT7; -.
DR STRING; 1904965.BJF83_02615; -.
DR OrthoDB; 7177610at2; -.
DR Proteomes; UP000185703; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000185703};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 234..493
FT /note="ComEC/Rec2-related protein"
FT /evidence="ECO:0000259|Pfam:PF03772"
FT DOMAIN 536..707
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF00753"
SQ SEQUENCE 780 AA; 80692 MW; BBFB387C1728C4FC CRC64;
MTTWLGTDAF GLRRPPDVRL LLPAVMAWLT ALGALAAPPR LSWACSVVAG GAAIGVYLRA
RPRSEPVALT LVAALACSAT VAAVTGAHVA RATGSAASRV AALEREAEFA ATVRTDPRSR
AGAPRPGRAE WVMVARTAWV RVDGRRTVSS AQVVVLASGP RWNGLLPGQE FRARGVFLPS
EGDPLTSALV LVRGPPEAVT RPSGLQALAG RVRAGLREAA SALPQPERGL LPALVVGDVR
LLREDTAEDF RSTGMAHLLT VSGSNLAVLT GFVLGLARWL RAPVWCSVAG GAVMIWLFVL
VCRPEPSVVR AAFMGSLALL ALATGRAHAA LGALSLTVLG VLFVAPGLAV SYGFTLSVLA
TAGILAFVPS WTRMWSRWLP QPVADAVAVA VAAQVAVAPV LVLLSAEVSW VAVPANVLAA
PVVATVTVAG FVLAALSVLW PTAAAVAAHP PGWGVAWIAW VAETGAGVPH GALPWRSDAV
GALVLAGILL ILVSARGWLL RVAAAIVVAV LLLFLAVRCV PGDWPPQGWD LVACDVGQGD
GFVLSAGAGS AIVADTGEDP AVIDACLTRL GVREVPLLVL SHDHADHVDG TPGVLRHRRV
GAALVPHGFG DTAMGRALAE DEVELWAGRR GQSFRVGPWL LRVLWPPPGY AGSVNDGSVV
VRADGASLSV LLTGDIEEQA QRRMLAGPDA GLLPVTVLTA PHHGANTQDP DFLAATEPVV
TVTSVGEDNA YGHPSPYTWA LLERLGRINL RTDRDGDVAV LDGGGTGPVR VVARGPAPGR
//
