ID A0A1Q9TTZ7_9ACTN Unreviewed; 664 AA.
AC A0A1Q9TTZ7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Acetoacetate--CoA ligase {ECO:0000313|EMBL:OLT28936.1};
GN ORFNames=BJF83_13420 {ECO:0000313|EMBL:OLT28936.1};
OS Nocardiopsis sp. CNR-923.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1904965 {ECO:0000313|EMBL:OLT28936.1, ECO:0000313|Proteomes:UP000185703};
RN [1] {ECO:0000313|EMBL:OLT28936.1, ECO:0000313|Proteomes:UP000185703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNR-923 {ECO:0000313|EMBL:OLT28936.1,
RC ECO:0000313|Proteomes:UP000185703};
RX PubMed=27902408; DOI=10.1099/mic.0.000386;
RA Schorn M.A., Alanjary M.M., Aguinaldo K., Korobeynikov A., Podell S.,
RA Patin N., Lincecum T., Jensen P.R., Ziemert N., Moore B.S.;
RT "Sequencing rare marine actinomycete genomes reveals high density of unique
RT natural product biosynthetic gene clusters.";
RL Microbiology 162:2075-2086(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLT28936.1}.
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DR EMBL; MKKC01000067; OLT28936.1; -; Genomic_DNA.
DR RefSeq; WP_075925760.1; NZ_MKKC01000067.1.
DR AlphaFoldDB; A0A1Q9TTZ7; -.
DR STRING; 1904965.BJF83_13420; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000185703; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:OLT28936.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000185703}.
FT DOMAIN 51..105
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 128..483
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 550..624
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 664 AA; 72947 MW; 2AD3FA0748AC89AA CRC64;
MTESSVPRVL WEPDEATVGS SNIVAFARWA AEHKGVRAFG EGTPAPASFD YDALWRWSVT
DIEGFWAAIW EYYGVRSETP RDTVLPERVM PGARWFPGVT LNYARHVFEG RDDGAVAIRH
ATELRPLGEW TWGDLRRRTA AIAAGLRERG VGPGDRVVAY LPNLPETVAA FYAVASLGAV
WSSCSPDFGV RSVIDRFAQI EPKVLLAVDG YRYGGRDFDR RPVVAELREA LPTVEHTVLL
DYLTPGAELE GTEPWSALEE GDASELEFAP VPFDHPLWVL YSSGTTGLPK AIVHGHGGIL
LEQLKNLHLH LDAREDDRVF WFTTTGWMMW NFLVSVLLTR ASIVLYDGSP AAPGLDTLWE
LAERAGTTIL GTSAGFLSSC MKEGVHPRRG RDLSALRAIG STGSPLSPEA FSWVYDEFGD
GLWLFSTSGG TDVCSCLVGG TPTLPVYEGE IQSRGLGMAV ASWDPDGKEI VGEVGELVVT
QPAPSMPVYF WGDPDGERLR DSYFSVYPGI WRHGDWIEIT DRGTAIIYGR SDSTINRGGV
RMGTSEIYRA VLALDEVVDA LVVDVPQEDG SSRIELFTVL RPDADLEGDL PAQIARRVRT
DCSPRHVPDR VRAISAVPRT LSGKVLEVPV KRILMGESPE RVVSRDSLAN PEALDYFTRL
SDQG
//
