ID A0A1Q9YD04_9FIRM Unreviewed; 724 AA.
AC A0A1Q9YD04;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BM735_07835 {ECO:0000313|EMBL:OLU39207.1};
OS Erysipelotrichaceae bacterium NYU-BL-F16.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Erysipelotrichaceae.
OX NCBI_TaxID=1917462 {ECO:0000313|EMBL:OLU39207.1, ECO:0000313|Proteomes:UP000186748};
RN [1] {ECO:0000313|EMBL:OLU39207.1, ECO:0000313|Proteomes:UP000186748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NYU-BL-F16 {ECO:0000313|EMBL:OLU39207.1,
RC ECO:0000313|Proteomes:UP000186748};
RA Cox L.M., Sohn J., Tyrrell K.L., Citron D.M., Lawson P.A., Patel N.B.,
RA Iizumi T., Perez-Perez G.I., Goldstein E.J., Blaser M.J.;
RT "Description of two novel members of the family Erysipelotrichaceae:
RT Ileibacterium lipovorans gen. nov., sp. nov. and Dubosiella newyorkensis,
RT gen. nov., sp. nov.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLU39207.1}.
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DR EMBL; MPJX01000154; OLU39207.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q9YD04; -.
DR Proteomes; UP000186748; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 5..292
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 293..558
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 724 AA; 84140 MW; 58D54A7F7947A3B0 CRC64;
MEQMPVLNEK QLEAVEQSEG YVRVVAGAGS GKTRTLAYRF AYLVNELGIL PSSILCVTFT
NKSANEMRNR IHRLIGDADT GYISTFHGFC NTVLKEEANA IHFPKSFMVL DNADIDSMLK
IVYEQRGLTS RDMTFSKARD MIEIQKIDRK PDYYYDLISL SLDQLYEKYA RAIETDDIIF
YGYLYQQKKN FGLDYNDLII LSLFIFKEND EIRLKWQERL EYIMIDEFQD IDSLQYRLMN
VLQGYHKNLF VVGDPDQTIY TWRGANVRFL LDFDQNYPQT KTIYLNENYR STPQILEAAN
KLIAVNYNRL PKDLYTKNQA GPNVHAMHFE DTAKEAKGIV EVIHHLLHKG YEYRDIAILY
RAHYLSRTLE DEFLQQEIPY TIYSGVPFFQ RMEIKDALAY LRMLIFKDDL DFQRTVNTPK
RNIGTSRMKF LEEYAISHQI SLWESLKENA ETEMFKKTRV NEYIELIESE NWKDRSVTEV
LSGLLDHSGY EAMLRLQGAQ DRLDNLAELK QSVSEFERNS GEEGDLEQYL NHIALFTASD
QEMQSQKVKM MTVHTAKGLE FPVVILVGLS ENIFPSKQTR TLEQMEEERR LAFVALTRAQ
KELYLSESEG LLANGGFRYP SRFLCDIDEP ILNWHPKPAE DLLIHTRASV NSRPALQRPL
NQNELLMPGD RVEHKIFGMG SVIETDLEKL SYLIHFDKLD TVRRLSAKAN LKKIGTAPKS
MGLN
//
