ID A0A1R0GWH8_9FUNG Unreviewed; 2547 AA.
AC A0A1R0GWH8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Dicer-like protein 1 {ECO:0000313|EMBL:OLY81249.1};
GN ORFNames=AYI68_g4647 {ECO:0000313|EMBL:OLY81249.1};
OS Smittium mucronatum.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX NCBI_TaxID=133383 {ECO:0000313|EMBL:OLY81249.1, ECO:0000313|Proteomes:UP000187455};
RN [1] {ECO:0000313|EMBL:OLY81249.1, ECO:0000313|Proteomes:UP000187455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALG-7-W6 {ECO:0000313|EMBL:OLY81249.1,
RC ECO:0000313|Proteomes:UP000187455};
RX PubMed=27343289; DOI=10.1093/molbev/msw126;
RA Wang Y., White M.M., Kvist S., Moncalvo J.M.;
RT "Genome-Wide Survey of Gut Fungi (Harpellales) Reveals the First
RT Horizontally Transferred Ubiquitin Gene from a Mosquito Host.";
RL Mol. Biol. Evol. 33:2544-2554(2016).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLY81249.1}.
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DR EMBL; LSSL01002626; OLY81249.1; -; Genomic_DNA.
DR STRING; 133383.A0A1R0GWH8; -.
DR Proteomes; UP000187455; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18034; DEXHc_dicer; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950:SF76; -; 1.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000187455};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT DOMAIN 79..271
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 459..663
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 747..837
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 1540..1611
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 2112..2351
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT REGION 613..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1938..1973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2547 AA; 288332 MW; 48422089B3B544C4 CRC64;
MNSGHDFQTG YVDPRYSENW SPEYYINNDL QDFSDQDCFN DFYQDPEFDH DTNIINGDFL
VNFENLSGGI KPRDYQKELF LRSLNKNTII VLETGSGKTL IASMIIEYFA QKDSPLIDFD
SFGASDPLVH HKPLKITLFL CNTTVLIEQQ GRFLSETTGV SVKIYKSRGR HGQYNHKEWD
DSWRSAQVHV MTSQTLLNCL RHGFVKISDI NLIIFDECHH CRKGTPYNQL MREFYDLAPV
DERPRVFGMT ASTANANESL EYSLNRIQQS MDSDIQTYNL PNSEGLNTGD LLNVTLEYDL
ELNNSSGWLG DFVFSQIKNY SEIESIKVEV NFIKKELGYY AGLFVMYALT SYWKDVVLKN
NPSSSSLPDN FSFNDHSNHS NSKNPVVKNN VKNDAVFREI NDAIKLIYLH GNLNNELFIR
NDFGIFKNGS LEYNFDHIYQ PGVHSWNSSF PYLTSKVNVL LQYLLKYKPL NRHSRHQDPF
SAIIFVNRRS VAYALSLIIR SFSEFDFIRC EPFIGSNQYK KKPILQALNL AFSSAKGAAS
LNQLSTLLRF KSGETNLLVA TQVAEEGLDI SSCNLVIRFD PALTLVSFVQ ARGRARHSFS
KYVIMVPKNL PKPGSSKPTF KSKSNVSQAV IDKSSHRDKS HYDSLVSMEK KFKNIPTSKN
NKNGSSDLVH GKLLNEISNR KSLPKNLSKS EYIAEMAIET SINLDNESLQ KLKNIAHEIH
LASISDSVSK SFFRVPETSA QLTSNSAKVV INKYVQSLPR DFYAINKIDY KVESLSSKFR
CKLTFPSCST IRTVVGPWSI SIKTAKQSSI FYSAIVLYFY GALNDYLMPV DLKTSHLKHS
TKRNILGSAY SDLENIIKNK YCTNFFQPFD LSVNSCLKSG RDPVPVSKLK PKIKPFSPLS
LLVPPFNSTP SKKRKLSNLN NTPSKLQKIS RSGKKSKPDF DVITFENFNP THWTPLSFNK
SKDEVGFDFD KKNIDLYAYV IDLNPFKFKN DTDSLGSLFH NLPHLNSEHV DELPLLAFFV
NQIPENMTIP LYSDTRSNIP RYYKFDPLKI KSNCFCDSAD YLLSDMSGSK CPNHNSSPDN
NKISVSTSQW EDLVIFTSSI FSLLHQAEYR VDPKDASYAF AIPTKDFEDK ILSVFKQRRD
FDVQKYNYND VSNLHKFDQF LGFSDKLPKF SSNDICWDQL KQFINGPIRL SSFEVSEWKE
LFSKHSFVSD INKYSICSPK NILKTTSNNT ISEILSDLDS NLTIQPHNPE FISSEAFFGI
SHNNLNSCNE LAVLKSYIPE KASDLRLLDY LYQNSLIFND MDYSSVTGCN LIKIEKIEFP
LNYLNKKINS TSSINDDSES YFEENSLNLF TSNTPREQSL SYNKSLPDPL KDIDLKLKGY
KSQINPNINL KELESLELKI LNTVSGRLLD LVAIPSMVRI LPWSVAQLQL LSVLPSLMHR
LHFTLIHFDL SKFLKLPISP SSLSSQPDIA NKSSLQNETD INIFDNIISF KDLIALSSKL
SKDSIAPLSP KIIDESLSER LVDKTVYENY QDLNRLPSWL FRTALTSQIP NEDVNYQRLE
MLGDSVLKLI VTTQLFSGLI PPISHEGILS SYTGLLVSNN FLAKVSRKTG LYYGLNQLNF
DAKHIFPPGI GWKRSVFPLP RTISHNSQPW SYVRGCPNRD YKLQNYSDRF ITDGCSCPPI
IIKTTPPSTH KTTDVTTSKV ADLDSIKNIS VGMESISPAH LPLQPNNVEK QKVIPTRDLE
LSEDQFLNLS SSQDKVSNVI SLSEIRLFSN LSKLKTEKNL TNQQSSSSFK YDEGISFKRF
ENKVDYDKFD LIHYLNKYKF DPDLHNNIID PHFSNSLVDA SMTQSSNDAQ SVCISAEKLP
DSSIINSNDL LNAKPKKGPT ISDILGSNSS NLIEINSSNN LNGIISDNLL NVEHKNEPNT
SEGLKLLEDL IMLTESNSKS NGKADSFQDV NPADNQQITN PEKEKLNRGP NSNAETILPK
PIYAFFGTKK PPEYVKKKGK SPYHKQHFNL VGPARHFSKA SLKTQADLVE SVLGASYKFS
GIESAFKVAK SLGIVKSDWN EWQDMSVSFN AHIKRSQNSD DEKFSDLIDL SFDPSDPIIS
PQDDISGNLK RINEVESIIG YKFKNSNILI EALTHSSPKT ELSSYQRLEF LGDAVISMLI
TDYYYDQVKV KKSLSQHIMT LVKHVAVSNS VLGLISYLHN FHKYIISDSN LLFNEIKSYS
DSIEYNISNW RYRKNSHIAS DFNTDTSVKN VFNSLNSNEP NSAQESLGNN AFKVKLRKPS
DVIICDSDDE TSTINPNLND FLSYDSSYDD FENGSPQWLD LPPELWKSSE PPKTMGDIHE
SLIGAVYADS GFSLSSTEKV FDKIFLPFIK KFIGPHQITL NSIIHAQMLI QSKKCHSFKY
STMEIDSAIK DAKINKLIDK KNRKILSSFN ILDYNSVNSY KNPFENRNYG SKGSIVEGGV
DRDVPPGLIP NMVELKKTNR SPYVTFLIIH NSEIIGFGSG LNSKKSKFRA AENAVSNWDS
GSPYSVINVL EECCKCIDNN SSPKSGI
//
