ID A0A1R0H050_9FUNG Unreviewed; 2545 AA.
AC A0A1R0H050;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 22-FEB-2023, entry version 23.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=AYI68_g3361 {ECO:0000313|EMBL:OLY82519.1};
OS Smittium mucronatum.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX NCBI_TaxID=133383 {ECO:0000313|EMBL:OLY82519.1, ECO:0000313|Proteomes:UP000187455};
RN [1] {ECO:0000313|EMBL:OLY82519.1, ECO:0000313|Proteomes:UP000187455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALG-7-W6 {ECO:0000313|EMBL:OLY82519.1,
RC ECO:0000313|Proteomes:UP000187455};
RX PubMed=27343289; DOI=10.1093/molbev/msw126;
RA Wang Y., White M.M., Kvist S., Moncalvo J.M.;
RT "Genome-Wide Survey of Gut Fungi (Harpellales) Reveals the First
RT Horizontally Transferred Ubiquitin Gene from a Mosquito Host.";
RL Mol. Biol. Evol. 33:2544-2554(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLY82519.1}.
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DR EMBL; LSSL01001454; OLY82519.1; -; Genomic_DNA.
DR STRING; 133383.A0A1R0H050; -.
DR Proteomes; UP000187455; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR PANTHER; PTHR22834:SF20; NUCLEAR FUSION PROTEIN FUS2; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR SMART; SM00325; RhoGEF; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR PROSITE; PS50010; DH_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000187455}.
FT DOMAIN 1079..1341
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1572..1834
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 146..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2545 AA; 286143 MW; 550BED90AAAB309B CRC64;
MHVKNEIKDV KLFKNASQAR EYFLASEKAN DSTASQAPNF SIPSSSVQKT SQMMNSVPRI
SSSKTLSSIN KTYNKRYGIE RCPDNFSILK GASIISKKGD NNRCQSPSNN YNNVIRPLYT
SQSTNIESNL NLKTEIISNN VSKAGTITSE SSKSSSSKHL DENSSIKKNN LDSVSNNNSP
SSIKEIDASI NSQDFVSCDK GLDVFPIKTN IPLGSVQTSE SLRPPTPPNT KIKDILKHKG
SLPEKISSNS NVLSVKNGYA NRRIPPLSDL SRNMGAKNKI NPPKNSISKN PLPASSSQYA
KFSKPKPLKD NAEIENSGIK PKFRRLVTPS PKIDSFSSNT VDKLNRNPNK QSKEAQKFNL
KQPTQFSNTQ LSSRSNNNYS SGGRNSPTTK QLVVSERLIE LSKSRPRILA ETQKQRIEIS
KQSEKKYTSI LAPLPPKSNN SKSAKSKISK VSSILDSGSK YQNKPVSSAP SKFQPNSLGK
KIYKKSYQGA KNTPSDIPDI KSPASDIPSA KINYKSSYDG FNLFDDRLNT HVESLLPFPK
YRDNVSNSFT HSTSKSISLP GSCSTRSENI ELDKKSTFGG LKSISSKRHT THFIGASDIK
YNEPINQLKT KEFSIGFPNG SLNNTPLNDK SLILTKEKDS KIMIISNNVQ SVKKNISHSE
DEHEELDTKS LDFSTFSTQF KSDDGDIYPL LEKKKYNLSD SCIISRNVRK TNSIKGSLIN
DLCKENNSDN NYNTAKSFSR IKIRKSINNA NIKKDNIENP IYGNPHSALN LSIDTDCKKK
SDFFSSKKIN IDHFKIENNN TQSVIHSSKS GAEIKPAALN LITKPTSSIT LSKNPIYSEN
QEEKLTKLKK EITDDKRMAR VYKPYPPNSN KDIVYKLDLE NCSLDESNIK NRISTADTEI
SFIDSSITLS LDRLENLANC SDRSFYNFYI KDGHQDSDQP IDNKSTLVMD DSPRINDFIS
RGTQIISSES CRYPNSFSPN YYNFDESNYH LYLGNEDGLH LNGSNSLSRD FSGVRNKSRM
SINDVIFSSQ SQLLIGDSTE KDKVEAVQSL IDFGLESISN PLEALSEKLH KNKKDLENFR
GSVIKEIAES ESSYLSDLYV LKELFYEPMY RPNHKISGFN NSDKKIVFNN LDEVISLTEK
VVYLISISLK HEIKSDDKGL DFPTIFIKVA QDIESVYSIY CSRFEKSLNR LAEITTDSYS
KYNFEISTAI LNNKNSHSGI VNHVDKKVSS DFKKGLSRNK KKTMKLRGHF ASSSNISNNP
SPETVAYTKS IVDFLNNQQK LLSGKTSSWD LRSLLIKPVQ RVLKYHLLLS RLAELSTGLN
KKRYFYVANM YTLVAENVNK AGNEPKSPLY SNSFQGANIF DNTNCSDTDL KSNSASDLNL
RTXXXXXXXX XXXXXXXXXX XLSLDRLENL ANCSDRSFYN FYIKDGHQDS DQPIDNKSTL
VMDDSPRIND FISRGTQIIS SESCRYPNSF SPNYYNFDES NYHLYLGNED GLHLNGSNSL
SRDFSGVRNK SRMSINDVIF SSQSQLLIGD STEKDKVEAV QSLIDFGLES ISNPLEALSE
KLHKNKKDLE NFRGSVIKEI AESESSYLSD LYVLKELFYE PMYRPNHKIS GFNNSDKKIV
FNNLDEVISL TEKVVYLISI SLKHEIKSDD KGLDFPTIFI KVAQDIESVY SIYCSRFEKS
LNRLAEITTD SYSKYNFEIS TAILNNKNSH SGIVNHVDKK VSSDFKKSLS RNKKKTMKLR
GHFASSSNIS NNPSPETVAY TKSIVDFLNN QQKLLSGKTS SWDLRSLLIK PVQRVLKYHL
LLSRLAELST GLNKKRYFYV ANMYTLVAEN VNKAGNEPKS PLYSNSFQGA NIFDNTNCSD
TDLKSNSASD LNLRTPKESI IKGDSDKLKV SKTSSPEVQK LKILIESFQS WQDTLGGLLK
DIHNWEDAFR ASILQMSSFS NVFNQFFGVE LFRDNVNSRL DDIVSSFSSP INFHKNIPEI
SFITDFNHLD KQYNDWFQRI SDQLCAYNSY SSEVSETVFV KVVHQSLKKK AYIPLLQLIK
LCQPFQKVSG RVFSCLRSNM PTYSFDEAIP GYKISLRNAV DLLLREIPKL LSLQNEAIEI
ILSSVGRIQI RFYKDVIELF SKEFSQFKLH TSIKHDGLTI ENKVSSFSIK DRVTDKHNIF
LNIMDQFDDS VSTPSESGLG SNIIDYSKKE WDVQSHHVYT EEDQICETKL TANDCLSYID
GVSSILHNIV FNVLPTNDLF LYGLNDTTKS GNDKYKKSSL LSKPSSIANK ISKVTNILSG
NKKKSKSSES RKSISGKGSD VSSINLDYHA NGRSCIHSIS SLSNNSMGRS SMAPNELSVD
AIDYSKSRKS VLNLPIFDLA ELFSSTAMND SVYSPSNDFS PIFSDDANHD CYFIDDENQS
NSHPKINIMG QEHQEKERDL SALEFIKFGL NNEEKLDIKN GYSALVNGVN NININQKSIG
HLSSKYKKSR ANGPLRRNVS AFSNMYMIHE YKDEKDSHEL SSKPLSFIND LESGKASSMV
KISNQLTRAA SNSSLEPSTV FSRHK
//
