ID A0A1R0H0N5_9FUNG Unreviewed; 560 AA.
AC A0A1R0H0N5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Phosphomevalonate kinase {ECO:0000256|PIRNR:PIRNR017288};
DE EC=2.7.4.2 {ECO:0000256|PIRNR:PIRNR017288};
GN ORFNames=AYI68_g3172 {ECO:0000313|EMBL:OLY82701.1};
OS Smittium mucronatum.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX NCBI_TaxID=133383 {ECO:0000313|EMBL:OLY82701.1, ECO:0000313|Proteomes:UP000187455};
RN [1] {ECO:0000313|EMBL:OLY82701.1, ECO:0000313|Proteomes:UP000187455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALG-7-W6 {ECO:0000313|EMBL:OLY82701.1,
RC ECO:0000313|Proteomes:UP000187455};
RX PubMed=27343289; DOI=10.1093/molbev/msw126;
RA Wang Y., White M.M., Kvist S., Moncalvo J.M.;
RT "Genome-Wide Survey of Gut Fungi (Harpellales) Reveals the First
RT Horizontally Transferred Ubiquitin Gene from a Mosquito Host.";
RL Mol. Biol. Evol. 33:2544-2554(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate +
CC ADP; Xref=Rhea:RHEA:16341, ChEBI:CHEBI:30616, ChEBI:CHEBI:57557,
CC ChEBI:CHEBI:58146, ChEBI:CHEBI:456216; EC=2.7.4.2;
CC Evidence={ECO:0000256|PIRNR:PIRNR017288};
CC -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate:
CC step 2/3. {ECO:0000256|PIRNR:PIRNR017288}.
CC -!- SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase
CC subfamily. {ECO:0000256|ARBA:ARBA00006495,
CC ECO:0000256|PIRNR:PIRNR017288}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLY82701.1}.
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DR EMBL; LSSL01001317; OLY82701.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R0H0N5; -.
DR STRING; 133383.A0A1R0H0N5; -.
DR UniPathway; UPA00057; UER00099.
DR Proteomes; UP000187455; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004631; F:phosphomevalonate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.230.10; -; 1.
DR InterPro; IPR016005; Erg8.
DR InterPro; IPR035102; Phosphomevalonate_kinase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR31814; -; 1.
DR PANTHER; PTHR31814:SF2; PHOSPHOMEVALONATE KINASE; 1.
DR PIRSF; PIRSF017288; PMK_GHMP_euk; 2.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|PIRNR:PIRNR017288, ECO:0000313|EMBL:OLY82701.1};
KW Lipid biosynthesis {ECO:0000256|PIRNR:PIRNR017288};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR017288};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000187455};
KW Steroid biosynthesis {ECO:0000256|PIRNR:PIRNR017288};
KW Steroid metabolism {ECO:0000256|PIRNR:PIRNR017288};
KW Transferase {ECO:0000256|PIRNR:PIRNR017288}.
SQ SEQUENCE 560 AA; 61599 MW; F5039D5BAC1D2FCD CRC64;
MAGIEDPITV IASPGKVLIV GGYLVLNKSY SGLVISVDAR VYSAVRTISH TQNTPTSQFS
VKVNSFQFTD GFWEYIVKRS VEADGSLTTS VVQVENEHST KNKFIHTVLE TVFWIISHRN
PEEINNLCDK SSTVSIVLGT DNDFYSQRSH FDSPSPSSQS IVKSDSQNNF ISIEQLQSLP
RFNLTNSTIG NVHKTGLGSS AALVSSLTAS LLLHFGIVSK SSFATFTQLN PKAKVTSFEK
LSTSSELAFK DNDRNIINSS DWHSKINNFD LKLIHNASQF SHCLAQGKIG SGFDVSCAIY
GSHIYNRFSP SLIQSAMTLP NSRSVNFVVD PSNSKFDSKV QKVFLPHGLH LVLVDINSGS
NTPSMVSKVL AWKTEFPDEG SQIWESISSK NDKVCTLFEK LDQLYTNNPE SYTAALDLCS
THPAAEWGLL VGKCADLISI QVIYILIEVF NTSNEIRRLM KRMGDLSGVP IEPDQQTSLI
DKCLLFPGVV MAGVPGAGGF DAIYCIVINE STRYDLVNSY IFKENSELTV TPLVCEEGDK
DHDGCVLVDT DIDILYSHFS
//
