ID A0A1R0H7K5_9FUNG Unreviewed; 1234 AA.
AC A0A1R0H7K5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=AYI68_g768 {ECO:0000313|EMBL:OLY85054.1};
OS Smittium mucronatum.
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX NCBI_TaxID=133383 {ECO:0000313|EMBL:OLY85054.1, ECO:0000313|Proteomes:UP000187455};
RN [1] {ECO:0000313|EMBL:OLY85054.1, ECO:0000313|Proteomes:UP000187455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALG-7-W6 {ECO:0000313|EMBL:OLY85054.1,
RC ECO:0000313|Proteomes:UP000187455};
RX PubMed=27343289; DOI=10.1093/molbev/msw126;
RA Wang Y., White M.M., Kvist S., Moncalvo J.M.;
RT "Genome-Wide Survey of Gut Fungi (Harpellales) Reveals the First
RT Horizontally Transferred Ubiquitin Gene from a Mosquito Host.";
RL Mol. Biol. Evol. 33:2544-2554(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLY85054.1}.
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DR EMBL; LSSL01000257; OLY85054.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R0H7K5; -.
DR STRING; 133383.A0A1R0H7K5; -.
DR Proteomes; UP000187455; Unassembled WGS sequence.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IEA:UniProt.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR GO; GO:0043596; C:nuclear replication fork; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:UniProt.
DR CDD; cd17753; MCM2; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF12619; MCM2_N; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000187455};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 791..997
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 96..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1234 AA; 138709 MW; 991D3A27E31DFABA CRC64;
MLKYLSTLKS HNSKLIAENV QLVRTVSEQK TRLKKKTIEN CDVYKTGRNK FETISEDIFV
DIFDFGAEID GCVGENLIYV KKPVLKTLKG IGNLSQNGER EILNPPESKK STRENRSKVS
PRNKDKNNDL YTIQEDDNEN YIEVSSFTKP HISDQHCDTK DGCLIPRNSV EVVKEKNINP
QKSKKTYKKA KNKTPEEIFD VIDISKEAGN KIMGHSEDLG DNPCKINDNT PKVSNPRASS
ENPDSSDSDS DCENSEKKYC FDSDFSDQGS FEKVRKNKRR ASSDDSDNEI TFPLTPGGGL
SYVSSPPAYR SGALPPSSPP PFSPFTPLYS RMDSDDDIDD LVEEAQEVAI DDANDEEEEG
ERLAMEDDEA DGEDLFGSDM ENDYKEIGGL DDYENVDIDD NSNFATLDPA ERAKIEARLR
RRDLEEGRVL NKSRIPAAFL QAMDDENWDN DDSNLLKKRS RRLLGEKNIH AALLDGTFDV
DDEEKALTLE DLKDIKGDSV GTWINEAGPR QAIAREFRHF LLSFVNENGI SVYGERIRKL
GEVNGESLDI DYPDLALSKP LLGYFLANAP REMLSIMDDL AMDAVLTVFP DYARICPEIH
VRIMGLPAVS SLRDLRQSQL NTLIRVSGVV SRRTSVFPQL KYVKFNCGKC GAILGPFYQD
NRTEVKIGSC TNCQSKGPFT VNSENTVYRN YQKITLQETP GTVPAGRLPR NREVILLWDL
IDVAKPGDEI EVTGIYCHSY DASLNARQGF PVFSTVIEAN SILKRSDEFA AFKLTEEDRR
EIRALSKSKD LERRIIKSIA PSIYGHSDIK VALALCLFGG VPKDIGGKLR TRGDINVLLL
GDPGTAKSQF LKYIENTAHR AVFTTGQGAS AVGLTASVRK DPVTREWTLE GGALVLADRG
VCLIDEFDKM NDTDRTSIHE AMEQQSISIS KAGIVASLQA RCSVIAAANP IGGRYKPSLP
FSQNVLLTEP ILSRFDVLCV VRDEVDSIKD ELLGKFVVQS HMNSHPLSKT NELQDQGATG
KEDQAPKSID MDEMELSDVE LIPQDLLKKY IMYARENVSP KIQKVDYDKV TYLYSELRRE
SLATGSIPIT VRHIEAIVRL CESRARMHLR DFVRSDDLDV AIKVTLSSFI SAQKFSVARS
LKRSFSKYLT VNSDFNELLY LMLCKLVQEK LTFYQFRNHG NFPNLIETSF EELELQARNS
QIYNLKNFYS SKLLVNQGFI VDFDKKVIVK RFDM
//
