UniProt: A0A1R0U262

Database: UniProt
Entry: A0A1R0U262_9MYCO

LinkDB:  A0A1R0U262_9MYCO 
Original site:  A0A1R0U262_9MYCO

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Ontology (5)   
   GO (5)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (46)   
   InterPro (25)   
   Pfam (11)   
   PROSITE (4)   
   SMART (6)   
All databases (53)   

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ID   A0A1R0U262_9MYCO        Unreviewed;      2512 AA.
AC   A0A1R0U262;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OMC10571.1};
GN   ORFNames=A5736_00090 {ECO:0000313|EMBL:OMC10571.1};
OS   Mycobacterium sp. SP-6446.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1834162 {ECO:0000313|EMBL:OMC10571.1, ECO:0000313|Proteomes:UP000187139};
RN   [1] {ECO:0000313|Proteomes:UP000187139}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SP-6446 {ECO:0000313|Proteomes:UP000187139};
RA   Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OMC10571.1}.
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DR   EMBL; MBEM01000211; OMC10571.1; -; Genomic_DNA.
DR   RefSeq; WP_076247985.1; NZ_MBEM01000211.1.
DR   Proteomes; UP000187139; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd05195; enoyl_red; 1.
DR   CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          6..433
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          2434..2510
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          469..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2512 AA;  271740 MW;  6C786FAA7335F326 CRC64;
     MKECADEPVA IIGIGCRLPG GIADHHALWR ALEEGVDAIG PIPADRWDVE RYYSPKAQRR
     GRMSARSGGF LTEVDTFDAA FFGISGRIAE QMDPQQRVLL EVCWESLEDA GIVPGDLAGS
     RASVFVGACS QDYGNLQSAP AELEGLGPHS ATGTFMSIIS NRLSYMFDLR GPSMTIDTAC
     SSSLVAVHMA MQSLRRGESE LALAGGVNLM LTPQFGIALS QAAMLSPDGR SRAFDSSANG
     YVRGEGAGMV VLKTLTQARL DGDRVYALIR GSAVNQDGRT QGITVPNGEA QEANFRVALA
     AAGIAPADVG YVEAHGTGTP VGDPIEANAL GRVLAAGRRA GRKALLGSVK TNIGHLEAGA
     GIAGLIKAAM CVYHRRIPPS LHFRNPNSDI DFAGLPIAVA TASQPWPDEY AYAVASVNSF
     GFGGTNANVV ITEPEPAKHV LPGSTVDYAE FLAVATGSQI GCIDDAVDET PERPAASGPE
     PTRSSQPAVL TFSARSEQAL DSLAEKYADL LRADAYDLET LGAALSLRRS HHEHRLVVVA
     SDAAEAAAKL QAAEVVRGHA PRSGTRKVAF LFNGQGPQWY AMGRTLLETS AVYRAKILEC
     DKVARQFLDW SIYEALMADE ASSRIGETQY LQPTMFALQV ALVELWQSWG VRPDAVLGHS
     MGEIAAAHVS GALSLSDALR VICHRARIQQ KADASGGMMF IALPAAQARE YCVAEPDQLW
     VSAVNSPRAC TVSGRRPALQ ALAKELDERG AFNRLLNVNC ACHSPDMEPL RDELLDALAG
     IVGGDTTVPM YSTATGARID GRELGTDYWW HNFRNPVLFE QAVKSLLADG YDTFVELSPH
     PVLVNSLNEI TTDAVVVSSL MRKKDDWTTF LDGFARLYNS GCPIDWRQRY PAGAPVLDLP
     TIVWNRQSFW NESTISRRYR TVAQEHPMLK RVDGARPTWE INWDDHRLSW VRDHDVFGSV
     IVPGACYVEA ALYAARELTG GPCALEFVDF ERACVLSDEP QLSRLELDPQ QGTFEFHQRA
     VRGDSWLRNA RGRYHPATTQ PSECFDVEAI LSRCTNTHKA VDIYGQLADH GYVYGPAFCG
     VDRLYVGTGE ALARIRPPRI LRNRLSGYLF HPAVLDACFQ SAILHPTTDR PDDLLPASYL
     PTGIERVRLY RDTGLPAWAY TRLRKHDDAL VVDIYLLDEN RQLIADFTPL TGKAVRRPAA
     TDRIENHFYH LTWQPSGQIV QPQCSAFTFE PADFADELEQ AGRTIAERLD RHVYATTYQD
     DVRRLCAAYA AACLNQLGPD TEFTVADLPG LLPKYHRAFR GILRLLVEDG SLSEHAGRFR
     IERTAGGALM AVAEDVERVW AEAFSKYPEC AWELLLLQRT GSNLHDVLTG AADPLELLFP
     SGSPGDIEAI YHNSPIARFY NLLARRIARR LTEGADPRRT LRVLEVGAGT GGLTASLLPV
     LPSQRCEYVF TDVSAAFIAA ARERFRDYDF VDYRVLDLEH ELPAEEFGPG SFDLVVAADV
     VHATADVKNS LLRLHDVLAP GGALLLLEAA PDTPWLDLTF GLTAGWWAAR DLRLRPDGPL
     LSVPVWQELL RSVGFDEVAA FGDPDHSGGG SQTVLLARTP RTAVEADESL VSVAAATVSD
     EHGGHRPEPL GNWMILTGTD RLGKDLATRI DQHGGRAVLV DSLAEDDFRT LQPTGIIDLR
     NASGLSLADA ITDSAVQLLD VLKTICRTDS QRWPRVYVLT RGAHALRNDE VELSGSSAWG
     IGVVARLELP QLRYATIDLD PTPTPGELDA VWAELRSPDN ECEIALRGGA RFVRRLGPAP
     HTPVTIPATD LPPDAGFALG ASVAGSLDEL RYYAEKRRPP DAGQVEIEVV ATGLNFLDVM
     IALGQVPPHE SAVGYRFGAE CAGVVTRVGT GVSHINVGDA VVAVNATQGA AASHITLPAT
     GVVAKPANLS FEAACALPIV FLTAWYALNK LARLCAGERV LIHAAAGGTG MAAVQIARLL
     GAEVFATAGS PAKRELLRAL GVKHVFDSRA IDFADEIRVA TCGAGVDVVL NSIAGESMSR
     SIACLAPYGR FVELGKRDLL GDRRLGLRPF LRNLAYYSFD LRQLLIDRPA EVHTELTMLM
     ARFAAGELHP LPYRVFHPAE AESAFRHMAA ARHVGKLVLA IAEREFPLVN APEPPSMTGT
     WLITGGLGGV GLAMAEHLAD GGVRHLVLVG RSGASDEGAG AKVAELRLRG ARVEVVAADI
     SSRDSVAALL DSIERELPPL RGVLHCAMVL DDALLTDLDR TRMTKVLAPK AFGAWHLHEL
     TAHLPLEAFV LFSSATSMVG NRGQANYAIA NAFLDHLAQA RAAQSLPVLT VNWGAVSDVG
     YVARHDDVGR IVATTGMRTF SSAEAFDAMM TLLRSGLPQV GVLPMDWPQF FRHYGLKPQT
     TPRYEHLSAP GEGGEVVDSG SSLRQQLRIQ PAEARGELVT SALKSRLAAV LGIPLDALDP
     HMPLMDYLDS LLAVEIGSWL EREFGTKVTI MELMKGPSAL QLSAQVLAQL DQ
//

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