ID A0A1R1BDW6_9BACL Unreviewed; 468 AA.
AC A0A1R1BDW6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
DE AltName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN ORFNames=BK127_34335 {ECO:0000313|EMBL:OMF04337.1};
OS Paenibacillus sp. FSL H7-0331.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1920421 {ECO:0000313|EMBL:OMF04337.1, ECO:0000313|Proteomes:UP000187480};
RN [1] {ECO:0000313|EMBL:OMF04337.1, ECO:0000313|Proteomes:UP000187480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL H7-0331 {ECO:0000313|EMBL:OMF04337.1,
RC ECO:0000313|Proteomes:UP000187480};
RA Beno S.M.;
RT "Paenibacillus species isolates.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMF04337.1}.
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DR EMBL; MRTH01000039; OMF04337.1; -; Genomic_DNA.
DR RefSeq; WP_076236733.1; NZ_MRTH01000039.1.
DR AlphaFoldDB; A0A1R1BDW6; -.
DR STRING; 1920421.BK127_34335; -.
DR OrthoDB; 62420at2; -.
DR Proteomes; UP000187480; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000187480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 40..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 468 AA; 51335 MW; 1CFFBF5C75370220 CRC64;
MFQLNFRIRK QVFLEKHFSG DSIDYRQIIS LFIPMLIDQA FLVCLNLLNI AMISSSGVAA
VSAVSMIDTL NILLISVFVA VSTGGTVVVA QYKGSGSDLM VSKAATSSIS LVSSLALCIS
LFLVLFHSPT LNFLFGTASA EVFAHAQTYL IGSSISYMGF AIVESICGAM RGIGKSRVSL
TLSLIMNLSY VLLNIVFVNF LDMGVLGMTI AVNVARYSAA IFALIYLAKM DATLHVRIRD
MFVLNLSMLK RILFIGIPFA VEQVFFNGGK MLTQVFIVSL GTYAMATNAI SASLAALFLV
PSIALSQTIV TVVGQCMGRQ NVKDARKFAR SFLWLSSFSL LLMGLIVIPL FQPIVSLFHP
PDEIVNDIFV IILITAIVQI PLWPISFLLP SALRAAGDSK FTSITSMLSM WLFRVTLGYV
LGVVLQFGII GVWVAMNSEW GVRGAAFLWR FRGQKWYKHR LIEPNDNS
//
