ID A0A1R1DDR4_9BACL Unreviewed; 637 AA.
AC A0A1R1DDR4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BK133_04130 {ECO:0000313|EMBL:OMF37733.1};
OS Paenibacillus sp. FSL H8-0548.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1920422 {ECO:0000313|EMBL:OMF37733.1, ECO:0000313|Proteomes:UP000187405};
RN [1] {ECO:0000313|EMBL:OMF37733.1, ECO:0000313|Proteomes:UP000187405}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL H8-0548 {ECO:0000313|EMBL:OMF37733.1,
RC ECO:0000313|Proteomes:UP000187405};
RA Beno S.M.;
RT "Paenibacillus species isolates.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMF37733.1}.
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DR EMBL; MRTK01000004; OMF37733.1; -; Genomic_DNA.
DR RefSeq; WP_076335107.1; NZ_MRTK01000004.1.
DR AlphaFoldDB; A0A1R1DDR4; -.
DR STRING; 1920422.BK133_04130; -.
DR OrthoDB; 9776552at2; -.
DR Proteomes; UP000187405; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OMF37733.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000187405};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 340..392
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 375..622
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 637 AA; 72634 MW; E4530934BE71886C CRC64;
MGRKCRAYVQ SIVNWLGRRS MQARLVAACI IILLIPSIGI SNYLFSQIED SYITDSLKQG
QYSIEMEKVN ILNQIEAMER AAQLTISEHE ILEYVSREED LPVEELLELY RGPFTDMINI
QINNPNIIHL RLYADNVHLS EVWPIIFHER RIQNESWFAK LDQLAGKELW MFSDQDPDIL
HRNVTEGTDQ MPKVSLVRVI ESGGRRVASI QVEMLLKHFS PKAFASIKDE GSQMMIADGS
GTVFLDENQP FASGNLELRQ AIVKEFAEMQ QQDITEKRFI VNQLPYLLVT TDLEQVDAHI
LNVVSLQASS ERISKAAKQI IAVNVISIGL LSIIMYIMNS FILKNLRRLT EAMKKVRRGE
MPTGLPLGGG GEIGELAHHF NKLIHTINEL IAQGVRKQAL TKEAELRTLH SQIDSHFLYN
TLENIKMLAE MENQRTISDS LTSLGGMMRY NFKWSGEYVS LQDEVRHIQN YIAVMNIRFD
EPIHLELHIP PRLLEIEVLK MSLQPIIENT VKHAGFGAEA SNSTIRIDVA ENEEANIVIT
LRDNGRGISV SRLEQLNERI HLDRNNELSL TQENINVKQT FGIGLQNVHQ RIQLYYGEQY
GLQVYSSEGQ FTEVVITLPK VLLMGGSSGY EENDNRR
//
