ID A0A1R1I222_9RHOO Unreviewed; 239 AA.
AC A0A1R1I222;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=tRNA pseudouridine synthase C {ECO:0000256|ARBA:ARBA00040675};
DE EC=5.4.99.26 {ECO:0000256|ARBA:ARBA00038943};
DE AltName: Full=tRNA pseudouridine(65) synthase {ECO:0000256|ARBA:ARBA00041975};
DE AltName: Full=tRNA pseudouridylate synthase C {ECO:0000256|ARBA:ARBA00043049};
DE AltName: Full=tRNA-uridine isomerase C {ECO:0000256|ARBA:ARBA00041803};
GN ORFNames=BJN45_15005 {ECO:0000313|EMBL:OMG52660.1};
OS Azonexus hydrophilus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Azonexaceae;
OC Azonexus.
OX NCBI_TaxID=418702 {ECO:0000313|EMBL:OMG52660.1, ECO:0000313|Proteomes:UP000187526};
RN [1] {ECO:0000313|EMBL:OMG52660.1, ECO:0000313|Proteomes:UP000187526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZS02 {ECO:0000313|EMBL:OMG52660.1,
RC ECO:0000313|Proteomes:UP000187526};
RA Salah Z., Rout S.P., Humphreys P.N.;
RT "Alkaliphiles isolated from bioreactors.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-65 in
CC transfer RNAs. {ECO:0000256|ARBA:ARBA00037670}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine(65) in tRNA = pseudouridine(65) in tRNA;
CC Xref=Rhea:RHEA:42536, Rhea:RHEA-COMP:10103, Rhea:RHEA-COMP:10104,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.26;
CC Evidence={ECO:0000256|ARBA:ARBA00036607};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMG52660.1}.
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DR EMBL; MTHD01000005; OMG52660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R1I222; -.
DR STRING; 418702.BJN45_15005; -.
DR OrthoDB; 9809101at2; -.
DR Proteomes; UP000187526; Unassembled WGS sequence.
DR GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02563; PseudoU_synth_TruC; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF56; TRNA PSEUDOURIDINE SYNTHASE C; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000187526};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 10..169
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
SQ SEQUENCE 239 AA; 27065 MW; D605FC754953CFFD CRC64;
MPILYRDEYI VVIDKPANLL VHRSEIDRHE TRFAIQILRD QIGQKVWPAH RLDRGTSGVL
LFGLSAEIAS VLGRQFADGS VGKRYLAVVR GHPPASGSID HALTRQRDDY EFQGERSSQE
AQPALTHFRR LATVELPVMV ERYPSSRYAL LELTPVTGRK HQLRRHLKHI AHPIIGDATY
GKGRHNRFFA EQLACHRLLL ACTHLTFRHP ANHQPIAVDV RPGGEFAALL DRFGWTGAQ
//
