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Database: UniProt
Entry: A0A1R1LNJ9_9GAMM
LinkDB: A0A1R1LNJ9_9GAMM
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ID   A0A1R1LNJ9_9GAMM        Unreviewed;       924 AA.
AC   A0A1R1LNJ9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   13-NOV-2019, entry version 14.
DE   RecName: Full=HTH-type transcriptional regulator MalT {ECO:0000256|HAMAP-Rule:MF_01247, ECO:0000256|SAAS:SAAS00724615};
DE   AltName: Full=ATP-dependent transcriptional activator MalT {ECO:0000256|HAMAP-Rule:MF_01247};
GN   Name=malT {ECO:0000256|HAMAP-Rule:MF_01247};
GN   ORFNames=BGP75_20360 {ECO:0000313|EMBL:OMH29109.1};
OS   Motiliproteus sp. MSK22-1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Motiliproteus; unclassified Motiliproteus.
OX   NCBI_TaxID=1897630 {ECO:0000313|EMBL:OMH29109.1, ECO:0000313|Proteomes:UP000187359};
RN   [1] {ECO:0000313|EMBL:OMH29109.1, ECO:0000313|Proteomes:UP000187359}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSK22-1 {ECO:0000313|EMBL:OMH29109.1,
RC   ECO:0000313|Proteomes:UP000187359};
RA   Nakajima Y., Yoshizawa S., Ogura Y., Hayashi T., Kogure K.;
RT   "Draft genome of Motiliproteus sp. strain MSK22-1.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates the transcription of the maltose
CC       regulon whose gene products are responsible for uptake and
CC       catabolism of malto-oligosaccharides. Specifically binds to the
CC       promoter region of its target genes, recognizing a short DNA motif
CC       called the MalT box. {ECO:0000256|HAMAP-Rule:MF_01247}.
CC   -!- ACTIVITY REGULATION: Activated by ATP and maltotriose, which are
CC       both required for DNA binding. {ECO:0000256|HAMAP-Rule:MF_01247,
CC       ECO:0000256|SAAS:SAAS01071122}.
CC   -!- SUBUNIT: Monomer in solution. Oligomerizes to an active state in
CC       the presence of the positive effectors ATP and maltotriose.
CC       {ECO:0000256|HAMAP-Rule:MF_01247}.
CC   -!- SIMILARITY: Belongs to the MalT family. {ECO:0000256|HAMAP-
CC       Rule:MF_01247, ECO:0000256|SAAS:SAAS01044130}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OMH29109.1}.
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DR   EMBL; MIEQ01000072; OMH29109.1; -; Genomic_DNA.
DR   RefSeq; WP_076720718.1; NZ_MIEQ01000072.1.
DR   Proteomes; UP000187359; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0045913; P:positive regulation of carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   HAMAP; MF_01247; HTH_type_MalT; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR041617; TPR_MalT.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR023768; Tscrpt_reg_HTH_MalT.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50005; TPR; 3.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|HAMAP-Rule:MF_01247,
KW   ECO:0000256|SAAS:SAAS00724627};
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01247,
KW   ECO:0000256|SAAS:SAAS00724618};
KW   Carbohydrate metabolism {ECO:0000256|HAMAP-Rule:MF_01247,
KW   ECO:0000256|SAAS:SAAS00724617}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000187359};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01247,
KW   ECO:0000256|SAAS:SAAS01008967};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01247,
KW   ECO:0000256|SAAS:SAAS00724612};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187359};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_01247,
KW   ECO:0000256|SAAS:SAAS00053185};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01247,
KW   ECO:0000256|SAAS:SAAS00053955}.
FT   REPEAT      470    503       TPR. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00339}.
FT   REPEAT      509    542       TPR. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00339}.
FT   REPEAT      749    782       TPR. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00339}.
FT   DOMAIN      853    918       HTH luxR-type. {ECO:0000259|PROSITE:
FT                                PS50043}.
FT   NP_BIND      51     58       ATP. {ECO:0000256|HAMAP-Rule:MF_01247}.
FT   COILED      486    506       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   924 AA;  105532 MW;  4EA00C6F16BF0E83 CRC64;
     MAPNNSNDNA ALMLIPSKFS QPECPCHTQP RERLHLRLEQ LSAFSLLLIH SPAGYGKTTF
     ANQWLRTKEL DTAWYSLDPS DNEEIRFAGY LLSSLNQAYP NSCEATLAIA QQTSLAQQTS
     FENLEQLFVR LFSELPPRDT PLILVLDDYH LIENPSIHGA LRFFIKHMPR WLKLVITSRT
     LPPLGIASLR VQGKLQEVNA TDLAFDDTEA LALLNQRLPF KADIKQVERI NQQIEGWASA
     LQLIALSATD DSSFERLHEE FSRGYSHVLD YLAEEVLSQT PENVRQFLFR TSILERFDER
     LASAVTGLEF PRPLLEQVER SGLFLLPQDN ARNWYRYHPL FAGFLQHQLK ISLPDEETAL
     HTVASDTWLE LGFPHEAVRH ALAASDSERI TNLLRKEGWN FYQQGQLRIL QQCLNALSSE
     HIAQDPVLTL LQAWAAQGRF GFEQVEPVLL AAEQHLPSQL SPEEWRATHG EFDTLRAQVA
     INQGRVEDAE QLAQQALEQL PEEKHRARIQ ALTILGEAGF CQGRLSKAQT RMQEAEQLAR
     SRGVTQTVIW SLCQQSENCI AQGFLQKAFN LQDKALQYAQ ERHLEELPLL EFIHRIRAQV
     LWEWHHLDAA NQACKKGLEA LEGQDQRWQL QCVVLEAKIA QSRGELDICR ARIEQVQQLL
     KGSSYHSDWL ANAHATLMTY WESCNDQESI RGWLEDAPPL PLATNHFAQC HARNWARAQT
     CLGNTTDAIE KILAIQQVAV RCQLVTDQNR NHIYLARAYW QQEDRQEALD HLHQALKLAT
     TTGFIGSFLR LGKPLIVMLK ALKKERDLEL MESSRTDRLL QLLQHQKDFS KALRITLDES
     LIEDILKQPD IPELIRATPL TRKEWQVLSL IHAGLSNDQI AQQQGVATST IKTHIRSLYQ
     KLNISQRQEA IKLADRMLSH IQGE
//
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