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Database: UniProt
Entry: A0A1R1MNT5_9BACT
LinkDB: A0A1R1MNT5_9BACT
Original site: A0A1R1MNT5_9BACT 
ID   A0A1R1MNT5_9BACT        Unreviewed;       444 AA.
AC   A0A1R1MNT5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   05-DEC-2018, entry version 8.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=BLW93_00390 {ECO:0000313|EMBL:OMH41380.1};
OS   Desulfurobacterium indicum.
OC   Bacteria; Aquificae; Desulfurobacteriales; Desulfurobacteriaceae;
OC   Desulfurobacterium.
OX   NCBI_TaxID=1914305 {ECO:0000313|EMBL:OMH41380.1, ECO:0000313|Proteomes:UP000187408};
RN   [1] {ECO:0000313|EMBL:OMH41380.1, ECO:0000313|Proteomes:UP000187408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K6013 {ECO:0000313|EMBL:OMH41380.1,
RC   ECO:0000313|Proteomes:UP000187408};
RA   Cao J., Shao Z., Alain K., Jebbar M.;
RT   "Genome sequence of a sulfur-reducing bacterium Desulfurobacterium
RT   indicum K6013.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OMH41380.1}.
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DR   EMBL; MOEN01000001; OMH41380.1; -; Genomic_DNA.
DR   RefSeq; WP_076712129.1; NZ_MOEN01000001.1.
DR   Proteomes; UP000187408; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000187408};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187408}.
FT   DOMAIN      323    428       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    270    270       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      32     32       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      37     37       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      88     88       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     125    125       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     165    165       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     273    273       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     337    337       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   444 AA;  49556 MW;  67604B62E69B4DBD CRC64;
     MSKKIAVIGT GYVGLVSGAC FAYLGHKVIG LDIDPEKIER LKKGEVPIYE PGLDKILRQA
     IDNGNIEFTT DYSHAVKNSD FIFIAVGTPS REDGSADLSY VESAYRSIVS QIEQGDFKII
     VNKSTVPVGT GRWAKKFISD LLRNRGIENP EDHFEVVSNP EFLREGKAVE DFMKPDRVVV
     GADNRDYAGM VASLYEKLQP AMIITDLPTA EMIKYASNSF LATKISFINE IANICEKAGA
     DVTVVARGMG LDHRISPHFL NAGCGFGGSC FPKDVKALVY TAKQYDVKPE LLEATLDVNE
     RQKLVLVEKL KKYYPSLSGL IVGVWGLAFK PDTDDMREAP SIPIIKRLLS AGATVKAYDP
     VATENARKVF KEELQKYPEK LIFVKDKYEA LEGVDALLLI TEWSEFKDVD FERFRNKVII
     DGRNLWEPSI VRRYTEKYEG IGKP
//
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