ID A0A1R1PJ07_ZANCU Unreviewed; 989 AA.
AC A0A1R1PJ07;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Double-strand break repair protein MRE11A {ECO:0000313|EMBL:OMH80909.1};
GN ORFNames=AX774_g5643 {ECO:0000313|EMBL:OMH80909.1};
OS Zancudomyces culisetae (Gut fungus) (Smittium culisetae).
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC Harpellomycetes; Harpellales; Legeriomycetaceae; Zancudomyces.
OX NCBI_TaxID=1213189 {ECO:0000313|EMBL:OMH80909.1, ECO:0000313|Proteomes:UP000188320};
RN [1] {ECO:0000313|Proteomes:UP000188320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COL-18-3 {ECO:0000313|Proteomes:UP000188320};
RA Wang Y., White M., Kvist S., Moncalvo J.-M.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMH80909.1}.
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DR EMBL; LSSK01001040; OMH80909.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R1PJ07; -.
DR Proteomes; UP000188320; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 3.30.110.110; Mre11, capping domain; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR038487; Mre11_capping_dom.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR PANTHER; PTHR10139; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR PANTHER; PTHR10139:SF1; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR Pfam; PF00149; Metallophos; 2.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR SMART; SM01347; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000188320}.
FT DOMAIN 323..521
FT /note="Mre11 DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01347"
FT REGION 466..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..776
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..826
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..974
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 989 AA; 109278 MW; C453FB6599F486AA CRC64;
MSDTNATHGD FKILVATDNH IGYLEKDPIR GKDSFNVFEE ILQQANINKV DFILLGGDLF
HLNQPSRTTI YETFRLFRKY CCVEKSTDTD TLDHSSGGNT ISNQNAAYAH LKSLGLVDGT
ERQSQSRSQH KQLEIKIPVY IIHGNHDDPS GERGLSALDL LSVAGFVRYF GKANNIDEIE
IHPLELRKGN NRLAIYGLGN IRDDRLHRTF LNKKVKFIKP PVEDTEADSA FNLMVIHQSN
VPRGAGGAFS AAKVTNYIPE SFLDECLDLV IWGHEHECKI DPHPNTAKKF YVSQPGSSVA
TSLSLSEAVT KHIGLLHIRG KRFKLTKIPL VNVRPLLIRD INISAYLDST AGKKKQKNQQ
EKLVEVVEEM LQEAQQMFTE RVSESYSFND EVGNNSDDRV TNFLGSTPLP LIRLRVEYSD
ADNAKSSVEI EPFYSHKFGL QFAQKVANPR EMIHFHRSKR RHLDRAVDPK SLVDNKNDGP
FSRGEEEGNS GPIKLEIGDI LKVENMELLI DGEINEAVKM FVEKGDSGAI SQFLTKTLKE
INLTVKTNII NSYGNRGANG CDDAGVVDFC DETIIKTHLD NFFSQKMKKR RVSLSLLEST
SNNSNSNNNS NNNNNKNEGG NDERQQGSLA RFSKSSLKDS SFTPMDLVLD SDCLDSDQEQ
SSNKGKNKDV GASVGFDSDL NSDSDFGAEK KPTTKGRRTT TKKQTAAATT RSRTTTRGAK
SAASKTKGRG KNKKDYSSDE YSSNNEIKNE KVIPSDSDDN DDDNDDDNDD DDGINEILSS
GSEFDDRPIS NKRSTQTKTA TQSSRNTRAK SIKQETDRDT GRGRGKGKGK STISGLEKFA
AIVIPESQSV STRATVASIK KESNLTGFFG SSVKSSTRTR GNTSNTTTRT SANASVNTNL
NKKRVEFTDH SDFLEDDDIS VMGNDLATSN TTASNSTNSS SYFGYNRRTK GAHGSNFVNL
DSDDADKGDG KGGDADDSFA NFSIYSLKR
//
