ID A0A1R1QB15_9BACI Unreviewed; 5366 AA.
AC A0A1R1QB15; A0A1R1RYU2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:OMI00189.1};
GN ORFNames=BTA30_09255 {ECO:0000313|EMBL:OMI31173.1}, BW143_18840
GN {ECO:0000313|EMBL:OMI00189.1};
OS Bacillus swezeyi.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1925020 {ECO:0000313|EMBL:OMI00189.1, ECO:0000313|Proteomes:UP000187367};
RN [1] {ECO:0000313|EMBL:OMI00189.1, ECO:0000313|Proteomes:UP000187367}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-41282 {ECO:0000313|EMBL:OMI00189.1,
RC ECO:0000313|Proteomes:UP000187367}, and NRRL B-41294
RC {ECO:0000313|EMBL:OMI31173.1, ECO:0000313|Proteomes:UP000187536};
RA Dunlap C.;
RT "Bacillus phylogenomics.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMI00189.1}.
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DR EMBL; MTJL01000042; OMI00189.1; -; Genomic_DNA.
DR EMBL; MRBK01000007; OMI31173.1; -; Genomic_DNA.
DR RefSeq; WP_076760978.1; NZ_MTJL01000042.1.
DR OrthoDB; 9765680at2; -.
DR Proteomes; UP000187367; Unassembled WGS sequence.
DR Proteomes; UP000187536; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19543; DCL_NRPS; 2.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR NCBIfam; TIGR01720; NRPS-para261; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 7.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 13.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 764..838
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2275..2349
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3798..3873
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4837..4912
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 5366 AA; 612016 MW; 2E2F4696DDFCA098 CRC64;
MSVFKNQETY WDNLFDEEDG LSVFPYFKTA EKASFTRAGY QEKCICRSLS PEVSQRMMTM
ANHSEMAIYL ILLSGIECLL YKYTDRTNLI LGIPTESKQK SSPSAVNTIV PLKNTLSCHS
TFKTVFEQLK EAVNNSLKNQ NLPFRKIVQH LNVQYDDERI PLIHTVVSFN EIHSLQFKED
VATDTLFHFN LENNGIHLQL FYNGNLYDER YMDQIVSHLD HLLSVILFQP QAAIDTVDII
PEAEKQQILF DFNDTAVNYP GSRTAFQLFE EQAERTPDHI AVKFENNQLT YSELNEKSNR
LARTLRNCGV QADTVVAIMA ERSLEMIVSI IAIWKAGGAY VPLDPEYPEE RLQYLLNDAN
VAVLVVQRQF KNSLVFDGPT IDLNDETSYH ADHSLLPPVA EHNHLAYVIY TSGTTGKPKG
VMVEHNGIVN SLQWKKAFFK YSAEDRVLVL FPYAFDAFIL NVFGPLISGA TLYLLPNQDN
KDLFVIQNVV KQEKITQFTT APRLLQAMIE QMNAEDFLHV QHVVVGGEQL EPDTVERLFS
LQPQIRLNNE YGPTENSVIS TFQPVYSADE QITIGKPVAN HQAYILGAHQ QIQPIGIPGE
LYVGGAGVAR GYRNQPELTE EKFVQHLLLP GQKMYKTGDL ARWLPDGRIE YLGRIDHQVK
IRGYRIELGE VEAALSNLEA VHEAAVVARE GENGAKQLYA YYVGEPSLTA GQFRAILARE
LPDYMIPSYF YHLERIPLTP NGKIDLKALP VTEETTRTEN EYIAPRNAIE ELLASIWQEV
LGAEHIGILD HFFDFGGDSI KSIQVSSRLY QAGYKIDMKY LFKYPTIAEL SPFVEPVSRM
ADQGEVQGRT SLTPIQHWFF EQKMPHAHHY NQAVMLYSAQ GFKEAPLRQA MERVAVHHDA
LRMVFEETPN GYDARIAGTD ESELYHLEVM NCKGDADPAQ SVANKASQIQ SSMELSQGPL
MKLGLFQCPD GDHLLIAIHH LVIDGVSWRI LLEDIASGYE QAERGQTVRL PQKTDSFPFW
AEQLAKYAQE TDIEQELAYW TELSRLELEP LPKDHICEGS LLKDSDVITI QWTEEETQQL
LKQANRAYNT EINDLLLTSL GLAVHKWTGM EEVSVNLEGH GREPVIPDVD ITRTVGWFTS
QYPIILKMEA GKELSQRIKT VKEGLRQIPN KGMNYSVIQY LSGRAEADRL QLHPEIRFNY
LGQFDQDLQQ HALQASPYST GLSMNENQAR TAVLDLNGMI AEGKLSLTLS YSNKQYERST
MEQFARSLKE SLNEIIVHCV SQQQTSLTPS DIFLKDIKIE ELEQLLEQTR EFGEVENIYP
LTPMQKGMLF HSLFDPSSGA YFQQTTFDLH GDLDIDSFSK SLDGLSQRYD IFRTNFYKGK
DQPLQIIFKT KKIGFEFIDL REMNKTLQEE RICAYAREDK VRGFDLAKDV LMRLFVFRTD
EKTYRFIWSF HHILMDGWCL PLITKEIFEH YFALLQHKQP ERATITPYSQ YIEWLDRQDA
EEAKRYWDQY LEGYEEQTVL PKDNHQAEAE HYLPEKVTCA IDADLTLKMK QTASKHHVTL
NTLLQTAWGI LLQTYNRSRD VVFGSVVSGR PAEIPNVETM IGLFINTIPV RIQCEDGTTF
AEQMKQTQER AVASQMYETY PLYDIQSHTT QRQNLITHLM IFENYPVDQY MESIGQHNES
SIAISNVQME EQTNYDFNLT VIPGEVINIH FEYNAKVYDQ ASVERIRGHL LQILHQVVKD
ADIQVEELEL LTEGEKWELL QTLNDTAAPY PQTTVYQQFE AQSQQTPDQA AVIDKDEQLT
YRQLNERANQ LARTLRAEGV QADQPVAIIS RNSVELVVGI LAILKAGGAY VPIDPEYPQD
RIQYMLEDSK AGIVLIQHDV RQQLTYEGVA VFLDEESSYQ EDASNLEPLS NANHLAYVIY
TSGSTGKPKG VLIEHRGLTN YIWWAKEVYV KGEKTNFPLY SSISFDLTVT SIFTPLVTGN
TIIVYDGDDK TALLSSIVQD PRIDIIKLTP AHLHVLKAMN IANKTAIRRM IVGGENLSTQ
LAQSIHEQFE GQIEIYNEYG PTETVVGCMI YRYDPDNDRR ESVPIGTAAA NTSIYVLDEG
MKPVPIGVPG EMYISGAGVA RGYLNRPELT AEKFVENPFV AGSRMYKTGD LAKWLPDGNI
EYSGRIDEQV KIRGYRIELG EIETAMHRVE AIKEAVVIAR EDVHGFKQLC AYYVSGQPLT
VFRIREQLSH ALPGYMVPTY FIELEKMPLT SNGKINRKGL PVPDLRLQDR AVYKPPRTRV
EERLVSTWEA VLGVEKIGIL DHFFDLGGDS IKSIQVSSRL NQLGYKMEIK HLFQYPTIAE
LSPHIEQNLH IPDQGEVKGK VSLTPIQHWF FEQTTIDPHY YNQAVMLHAP QGFQESSLRK
TLQKLGEHHD ALRMTFRATE NGYEAWNAEI VQSELYHLEV MNLKTEADPG PAIEAKANQI
QGSMSLSDGP LLKAGLFQCA DGDHLLIAIH HLIVDGVSWR ILLEDIVSGY KKAENGQVIQ
LPQKTDSFRL WAERLSEYAQ SATIKEEQEY WTEIEQTDVK PLPKDFHETQ TFSKDSETVT
VEWTKEETEQ LLKQANRAYN TEINDLLLTS LGLSISHWSG LEQIAFHLEG HGREQVVPDI
DISRTVGWFT SLFPVVLHMQ PGKNISHYIK TTKEGLRQIP DKGIGYGVAR YLSGATPLPP
AKMCPEISFN YLGQFDQDLQ HHAIQLSSYS CGSDSSENQV SPYVLNMNGM IAKGRLVLTI
SYSNKQYARE TINRLSAFIQ SDLRTIIEHC VHKEQSELTP SDILLKGMTI NELDQLLIQL
PQAGEIENVY PLTPMQKGML FHSLLDEDSS SYFEQASFDL QGELKIDRFA ACLERLFEKY
AVLRTSFYSG WNNVPLQIVY KTERPKVHFA DLRDMDKNRY EDEIRSYRRK DQAKGFDLAQ
DQLMRIAIFR MEDRKYHLIW SFHHIVMDGW CLHLLTNEVF EHYIALQEGR EAEPVYTAPY
SNYIEWLDQQ DHEEAKRYWS EYLESYKGET RILHKRPQHE PKAYAYANVT CQLDQEQTKQ
LQQIANQHQV TLNTLIQTLW GILLQKYSGT GDVVFGSVVS GRPAEIPGVE QMIGLFINTI
PVRIRCDEDS SFTEAMQMVQ EKALTSQAYD TYPLYEIQAQ TEQKHNLIDH IMIFENYPIG
QQVEQADHGA LELDIKNFHM EEHSHYDFNL VVIPGEQLAV HFGFNQNEYE QSEVERVCGH
FEQLTHQVLQ HPDIKIEELE LLSLQEKEHL LNRFQSNDMH YSREQTIHQW FEEQARRTPD
RLAVVFEGAQ LTYGELNRRA NQLARTLRAE GVQAEQLVGI MVERSLEMIV GILAILKAGG
AYLPIDPYSP SERIHYIVRD SGINVLLLRG KLPDNIVFSE TCIDILEEHA YHETDANLAL
PCRSNQLAYA VYTSGTTGTP KGTLIEHRQV IHLIEGLRRQ VYSAYEAGLH VAMLAPYYFD
ASVQQMYASL LLGHTLFIVP KEEVSDGAAL CAYYRQHRID ITDGTPAHLK LLIAADDRQG
VPLRHLLIGG EALSKTTVTK FMHLFTVHGA APVITNVYGP TETCVDASLF NIDVSADDWT
RSQIHAPIGK PLGNNRMYIL DSLQRLQPVG VQGELYIAGD GVGRGYLNLP ELTNEKFVDD
PFVPSSRMYR TGDLARLLPD GNIEFIGRID HQVKIHGFRI ELGEIESVML NVPEIQEAVV
TAFEDAEGEH YLCGYYVADE PFPISELRDG LVRHLPGYMM PAYFVQLDQM PLTPNGKLNR
QLLPAPDGKR YVGTEYVSPR TSTEIQLAKI WQDVLGLEQV GIRDNFFDVG GHSLRATTLV
AKIQKQLHVQ IPLRNVFQFP TIEQLAQAIT MMEQTGYASI PAIEKRPYYP VSSAQKRLYI
LNHLEGGELS YNMLGLMSVE GELDRDKLQQ SFAELIQRHE SLRTGFKMVD GEPVQYVLDH
VEFAVELYQA REDEADLYIR QFVRPFQLDE PPLLRVGLIE LQPNRGILLF DMHHIISDGT
SMSILIKEFV RIYEGEALPP LRIQYKDYAV WQTGEARLKQ VQKQEAYWLD LYGGDIPILH
LPTDYIRPST RDFTGATLHF AIDEQRSAGL KHLASKTEST LYMVLLASYT LLLSKYSGQE
DIIVGSPIAG RQHADLDSII GMFVNTLAMR NYPAKEKTFS QYLAEVKENA LKAYEHQDYP
FEALVDQLDI ARDLSRNPLF DTMFVLQNTE QEQLVMNNLT FSPYPSEHTM AKFDLTLTAV
EEDTCIHCTM EYLTTLFKPE TIERMMRHFV QLIDAIIEHP EAKLASLDMM TPQEKSDIWE
LFNDTAVNDK RIPSTIHQRF EQQAEHTPDH VAVMFENQTW TYRQLNERSN QLARVLRNQG
VGADQAVAVL TERSENMVIG ILAILKAGGA FLPIDPELPD ERRAFLVKDS GADVLVTCTG
HTVPPSFEGA VVLLDDPLVY QGEASNLNLS YAENHLLYVI YTSGTTGKPK GVQLEHKTML
NLLDFEWEHT QLRFDRVLQF AVMSFDACYQ EIFSTILSGG TLYIIDNETK REIRELNDFV
KTNRIQTAFL PTAFLKLLAS EKQYFEPFAE CVDHIIAAGE QLIMTNILRD MLVRHQCTLH
NHYGPSETHV VTVCTVDPEI HQELPPIGKP ISNTEIFILN EAGTLQPIGI VGELCIAGIS
LARGYHNRES LTLEKFVPHP YDANQRMYKT GDLARYLPDG NIEYVGRMDD QVKIRGYRIE
LGEVEAALLN IEYVREAVVL AKNHAEGQSD LYAYFVAEQA LPISQLREKL ANQIPGYMIP
SYMMQLEQMP LTANGKVNRG ALPLPETGLQ TGIEYVAPRT RLEEQLVHIW KEVLKLEQVG
VKDNFFDLGG HSLRGMTLVA KIHKQLNKSI SLREVFQAQT IEEMAKVIAG AETCGPDDIP
VAEVKDVYPV SSVQKMVYLS TQIEGGELSY NMPGILTLEG RIDMDRLQAA FHRLIQRHES
LRTGFDMIRG EPMQVIKPQV EFSIERYKAA AEEVEELFRA FVRRFDLSQA PLLRVGLIEL
EQDKHVFMYD MHHIITDGAS MNIFVEELIQ LYDGKELAPL RIQYKDFAAW QQQAGQRERI
KRQEDYWLDV FHEELPPFEL PKDFARPPVR SFDGKRYNFV LDEPVIQSIK QMEELTGSTT
YMILFAAYTI LLAKYSGLED IVVGTPIAGR MHEDLQHIIG MFVNTLAIRT APVGEKTFMD
YVTETKETML KAYENQEYPF EELVEKLGVK RDLSRNPLFD TMFVLQNTEQ TDIEVDSLAV
RPYEQTHTVA KFDLQLTFVI NQHEIQGSFD YCTKLFKKKT IAMLAKDYVM ILSAMIQNPS
IPLKDIQLSE KVNKSKHFTS AIELDF
//
