ID A0A1R1SB56_9ACTN Unreviewed; 316 AA.
AC A0A1R1SB56;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:OMI35565.1};
GN ORFNames=SPAR_30671 {ECO:0000313|EMBL:OMI35565.1};
OS Streptomyces sparsogenes DSM 40356.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1331668 {ECO:0000313|EMBL:OMI35565.1, ECO:0000313|Proteomes:UP000186168};
RN [1] {ECO:0000313|EMBL:OMI35565.1, ECO:0000313|Proteomes:UP000186168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40356 {ECO:0000313|EMBL:OMI35565.1,
RC ECO:0000313|Proteomes:UP000186168};
RA Coyne S., Seebeck F.P.;
RT "Genome sequence of Streptomyces sparsogenes DSM 40356.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMI35565.1}.
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DR EMBL; ASQP01000393; OMI35565.1; -; Genomic_DNA.
DR RefSeq; WP_076971427.1; NZ_ASQP01000393.1.
DR AlphaFoldDB; A0A1R1SB56; -.
DR Proteomes; UP000186168; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016833; F:oxo-acid-lyase activity; IEA:InterPro.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:OMI35565.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186168}.
FT DOMAIN 25..293
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 316 AA; 33210 MW; C1269F7B50FF8D85 CRC64;
MTSENTSPTG ALPRVARRPG MPEEVRVYEV GPRDGLQAEA VRVPTAVKAE FVRRLVGAGL
TTVEVTSFVS PRWIPQLDDA HEVLTAVGPL DGVRLPVLVP NDRGLERALA AGAREIAVFA
SATESFARNN LGRDVAGVLA MSEPVVRRAR SAGLPVRGYV SMCFGDPWEG DVEPREVASV
ARALMDMGCT SLSLGDTIGT GTPGHVLELL DTVLEAGIPL ERTALHFHDT YGQALANVHA
ALTAGITEFD SSAGGIGGCP YARSATGNLA TEDLVWMLRG LGIRTGVDLT ALAATSRWMA
GHLGRPSPSR VVTALS
//
