ID A0A1R1SDX2_9ACTN Unreviewed; 344 AA.
AC A0A1R1SDX2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=SPAR_26226 {ECO:0000313|EMBL:OMI36447.1};
OS Streptomyces sparsogenes DSM 40356.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1331668 {ECO:0000313|EMBL:OMI36447.1, ECO:0000313|Proteomes:UP000186168};
RN [1] {ECO:0000313|EMBL:OMI36447.1, ECO:0000313|Proteomes:UP000186168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40356 {ECO:0000313|EMBL:OMI36447.1,
RC ECO:0000313|Proteomes:UP000186168};
RA Coyne S., Seebeck F.P.;
RT "Genome sequence of Streptomyces sparsogenes DSM 40356.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMI36447.1}.
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DR EMBL; ASQP01000335; OMI36447.1; -; Genomic_DNA.
DR RefSeq; WP_065967796.1; NZ_ASQP01000335.1.
DR AlphaFoldDB; A0A1R1SDX2; -.
DR STRING; 67365.GCA_001704635_03292; -.
DR Proteomes; UP000186168; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OMI36447.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186168};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 21..69
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 81..287
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 344 AA; 38733 MW; 6BFBA2442A5713F4 CRC64;
MRLYHSRPTE PGYRRLRHGR GFRYLDAQGE PLRDRAELDR IRGLVIPPAW RDVWICARPN
GHLQAVGTDA AGRRQYLYHP RFRAEQEQAK HEHVLDVAEA LPAMREAVEG HLRDRGLTRR
RVLATAVRLL DLGFFRIGSD RYAELNNSYG LTTLLREHSR CRRGAVLFSY TGKHGKEIVR
TVVDPAACRS LTALRRRRGG GSRLLAYWER RAWHDVSGAD VNAYLKELVG LDITAKDFRT
WHATVMAAVA LAVSEPVARS ETARRRAIAR AAREVSGYLG NTPAVCRASY INPRVIELYE
EGVTVAAALP HLGDEGTYGV PATQGPAERA VLRMLRDGRP PREP
//
