ID A0A1R1SE55_9ACTN Unreviewed; 658 AA.
AC A0A1R1SE55;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Heparinase II/III family protein {ECO:0000313|EMBL:OMI36681.1};
GN ORFNames=SPAR_24976 {ECO:0000313|EMBL:OMI36681.1};
OS Streptomyces sparsogenes DSM 40356.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1331668 {ECO:0000313|EMBL:OMI36681.1, ECO:0000313|Proteomes:UP000186168};
RN [1] {ECO:0000313|EMBL:OMI36681.1, ECO:0000313|Proteomes:UP000186168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40356 {ECO:0000313|EMBL:OMI36681.1,
RC ECO:0000313|Proteomes:UP000186168};
RA Coyne S., Seebeck F.P.;
RT "Genome sequence of Streptomyces sparsogenes DSM 40356.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMI36681.1}.
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DR EMBL; ASQP01000325; OMI36681.1; -; Genomic_DNA.
DR RefSeq; WP_065968069.1; NZ_ASQP01000325.1.
DR AlphaFoldDB; A0A1R1SE55; -.
DR STRING; 67365.GCA_001704635_03543; -.
DR Proteomes; UP000186168; Unassembled WGS sequence.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.70; -; 1.
DR Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR InterPro; IPR008929; Chondroitin_lyas.
DR InterPro; IPR012480; Hepar_II_III.
DR InterPro; IPR031680; Hepar_II_III_N.
DR PANTHER; PTHR39210; HEPARIN-SULFATE LYASE; 1.
DR PANTHER; PTHR39210:SF1; HEPARIN-SULFATE LYASE; 1.
DR Pfam; PF07940; Hepar_II_III; 1.
DR Pfam; PF16889; Hepar_II_III_N; 1.
DR SUPFAM; SSF48230; Chondroitin AC/alginate lyase; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Periplasm {ECO:0000256|ARBA:ARBA00022764};
KW Reference proteome {ECO:0000313|Proteomes:UP000186168};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 129..310
FT /note="Heparin-sulfate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16889"
SQ SEQUENCE 658 AA; 71662 MW; 81DB4DB090A1B376 CRC64;
MTVGSGSPGW YLRRLSRMGP REIGGRAVDA VRRRRWRSAP PDCPSVTGAR FTAVLPDGAI
AAVSPDAAKR LVAEADRLMA GQAEYFGVVR DDLVDPDWCH DPKTGRRAPW GHAFDVPYRN
EDAVGDIKQI WEPSRHQYLT RLAAAYAITG NERYAERVAE HLRSWWAANA PLRGVHWVSG
IELGIRLLSW VWIRRLLDGW PGAAGLFEGN PVARNQIWHH QRWLAAFPSR GSSANNHVVA
EAAGQFAAAC AFGWFPDSAR WRAGALRSLE RHLRSNTFHS GLNRELATEY HGLVLELGLA
AVAEADAAGV PVPASIRLVL LRMTDALAAV VDGRLRPPRQ GDADDGHGLV VDGAGTDRWA
SLLATGDAVF GRLDWWPTVT ATDVRTPLLA ALVRPYGKHG AAPAVARPAR RPAHFADAGM
TILRGPAEIW CRCDGGPHGF LSIAAHAHAD ALSVEVRHDG VDVLADPGTF CYHGQPAWRR
YFRSTLGHNT LQLDGDDQSV SGGPFLWTRH ARSRVLLADT SGASAGGTAR WCAEHDGYLP
SVHRRRVELT PAAEELTVVD EVRGPRRAVR LAFHLGPAIT ADLVGNRARL TWARDGEDRS
AVLDLPGQLS WRAHRGETDP PLGWYSAGFG RKEPATTLVG TGFADGVEGF TTVLRFRG
//
