ID A0A1R1SGP9_9ACTN Unreviewed; 300 AA.
AC A0A1R1SGP9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Dihydrodipicolinate synthetase {ECO:0000313|EMBL:OMI37475.1};
GN ORFNames=SPAR_20775 {ECO:0000313|EMBL:OMI37475.1};
OS Streptomyces sparsogenes DSM 40356.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1331668 {ECO:0000313|EMBL:OMI37475.1, ECO:0000313|Proteomes:UP000186168};
RN [1] {ECO:0000313|EMBL:OMI37475.1, ECO:0000313|Proteomes:UP000186168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40356 {ECO:0000313|EMBL:OMI37475.1,
RC ECO:0000313|Proteomes:UP000186168};
RA Coyne S., Seebeck F.P.;
RT "Genome sequence of Streptomyces sparsogenes DSM 40356.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMI37475.1}.
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DR EMBL; ASQP01000288; OMI37475.1; -; Genomic_DNA.
DR RefSeq; WP_065958361.1; NZ_ASQP01000288.1.
DR AlphaFoldDB; A0A1R1SGP9; -.
DR STRING; 67365.GCA_001704635_01320; -.
DR Proteomes; UP000186168; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF19; 5-DEHYDRO-4-DEOXYGLUCARATE DEHYDRATASE 2-RELATED; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000186168}.
FT ACT_SITE 141
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 166
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 53
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 300 AA; 31930 MW; AB40899C419E35FE CRC64;
MDYSPLRAAL ADVVAIPVTP YDAEGAVDQD TYRALLRRLL DGGVKAVTPN GNTGEFYALT
LAERRLVTEL TVAETGDRAA VLVGVGHDVT TAVEAARHAR EAGAGMVMVH QPVHPYVSQD
GWVDYHRAIA EAVPELGVVP YLRNPLIEGS AIARLGEACP NVIGVKYAVP DAARFAAVAR
DAGLDRFVWV AGLAELYAPS YWAVGATGFT SGLVNVAPKV SLDMLGALRA GDYPAAMKVW
EQIRRFEDLR AAQQSANNVS VVKEALAALG LCRRDIRPPG SALPEPQRAE VAALIQGWAI
//
