ID   A0A1R1X0M0_9FUNG        Unreviewed;       910 AA.
AC   A0A1R1X0M0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Set1/Ash2 histone methyltransferase complex subunit ASH2 {ECO:0000313|EMBL:OMJ08175.1};
GN   ORFNames=AYI70_g11719 {ECO:0000313|EMBL:OMJ08175.1}, AYI70_g5512
GN   {ECO:0000313|EMBL:OMJ18174.1}, AYI70_g7163
GN   {ECO:0000313|EMBL:OMJ15599.1};
OS   Smittium culicis.
OC   Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota; Kickxellomycotina;
OC   Harpellomycetes; Harpellales; Legeriomycetaceae; Smittium.
OX   NCBI_TaxID=133412 {ECO:0000313|EMBL:OMJ08175.1, ECO:0000313|Proteomes:UP000187283};
RN   [1] {ECO:0000313|EMBL:OMJ08175.1, ECO:0000313|Proteomes:UP000187283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GSMNP {ECO:0000313|EMBL:OMJ08175.1,
RC   ECO:0000313|Proteomes:UP000187283};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the cclA family.
CC       {ECO:0000256|ARBA:ARBA00038149}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OMJ08175.1}.
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DR   EMBL; LSSN01005865; OMJ08175.1; -; Genomic_DNA.
DR   EMBL; LSSN01002621; OMJ15599.1; -; Genomic_DNA.
DR   EMBL; LSSN01001820; OMJ18174.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R1X0M0; -.
DR   STRING; 133412.A0A1R1X0M0; -.
DR   Proteomes; UP000187283; Unassembled WGS sequence.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd12872; SPRY_Ash2; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.90.980.20; -; 1.
DR   InterPro; IPR037353; ASH2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR10598; SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR   PANTHER; PTHR10598:SF0; SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR   Pfam; PF00622; SPRY; 2.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:OMJ08175.1};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187283};
KW   Transferase {ECO:0000313|EMBL:OMJ08175.1}.
FT   DOMAIN          241..429
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REGION          163..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..213
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   910 AA;  102023 MW;  AC6931BC16C26CED CRC64;
     MSHEKLKIFS QTNITKDKSS LLFSSAESGP QKYEDGRTYF HYKADVSRFI DSHWNYFWTK
     ARGETWINSA SSALSTNSSG NNLDEGRFES GKAKYNKNGM WALVDSTRIP SSYDISSSQH
     KTRTAMYNIS PQGSLIPISD SKIFSASNLN LLNYNSSTNI LSSLSNSKKR RKSENSKSQI
     KKSKLKSSRV TRTSTRATSS EKNSGAPKSK SSVNINNYNQ VVTGNKKYVF EEFNDYINPE
     TEEWSIKMWP DLDNPLSAVM MQSDLTHSAP QMKFSGINNE IVFNDSGYRV SKASHGVVSG
     TYYYEVEVLK PSKTNGNLRI GFAQISADLQ APCGYDHFSY SMRLNPATRF HASVGNMYGE
     PLEIGDVLGC LIHLPKLEKE MSSDLNARRW DYKSVYKPFD YKQPKHIKPP TLETKDGEVI
     VPNIKLEELN LPPLPIVKDS EIVFYKNGKS MGTAFRGLFL GKYYPAISSY MGGKAKVNFG
     GTTSPFKFEP PCKYNDQPIC AFAELSKDFD KTKDKSMDNN KDNFIDSENI LKLPKDIIKD
     KGEEYNSGDN EKIDSEYKNI ESNSLPQIHE TKGTNIEAEK ENTITTSVDL LDTNKTYHEI
     KMDDVNESKG LAANEGEMDF VNVSKGLAVN EGEMDVVNEL KDLICSKNNR ELIKDEKKAF
     SETSEIKSSE TNNEVPNLGA AEIKLSECNK IVSSVEATEI KDIETVDLSF TEISKVRSKE
     LKEDFLIVET EAQSNEIVDE TPYVEAEKNV PKEQMSEIDR AEVSNFEEIV RAEAGESKSN
     ESKHELGMVE SGEVGSTKVF GEAKVGEIFS KEEKEISEPI IEDKGCINDN KEVMKEFTSA
     SSLEGQELLV EEIEKEREVG GLNDTMLVCE VNKEREGVAS DILEKEEVCK EGDGEKLVKR
     VIEWGGVKFS
//