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Database: UniProt
Entry: A0A1R1Y631_9FUNG
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ID   A0A1R1Y631_9FUNG        Unreviewed;      1096 AA.
AC   A0A1R1Y631;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 13.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=AYI70_g2999 {ECO:0000313|EMBL:OMJ22245.1};
OS   Smittium culicis.
OC   Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota;
OC   Kickxellomycotina; Harpellomycetes; Harpellales; Legeriomycetaceae;
OC   Smittium.
OX   NCBI_TaxID=133412 {ECO:0000313|EMBL:OMJ22245.1, ECO:0000313|Proteomes:UP000187283};
RN   [1] {ECO:0000313|EMBL:OMJ22245.1, ECO:0000313|Proteomes:UP000187283}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GSMNP {ECO:0000313|EMBL:OMJ22245.1,
RC   ECO:0000313|Proteomes:UP000187283};
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OMJ22245.1}.
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DR   EMBL; LSSN01000809; OMJ22245.1; -; Genomic_DNA.
DR   Proteomes; UP000187283; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000187283};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187283};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      118    463       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      527    960       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      997   1075       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
SQ   SEQUENCE   1096 AA;  124507 MW;  1895896B5406C9EC CRC64;
     MDSPSSKYKH EALMNISDIS SDPVNDISKR MKINKKSNLT LNELKKKQDM EKESDFQRQL
     AALESTEKKE KEGKDLWARP PIPDFSPETT NIAFQQMEIV DHYNPTRQEL SLRLFGVTDD
     GNSIMCEVYN FQSYFYVPAP SGFNPDNIEN IRRHLNSILA GESGLNKDLD SVTKMETVNK
     ESLYGYTGGK KAPFWKIYMR LPKAISTARR MFERGIDIPG VGSYASQTFE SNLEYVIRFL
     VDMKLVGSGW LELAAGKYKI RSDAEKKTHC QLEVEICYTN IISHEPIQEW SRVAPLRILS
     FDIECAGRKG VFPEPQHDPV IQIAGMITRQ GDDRPFVRTL FTLGECSPIV GSQVICCQTE
     EILLAKFAEF IQISDPDVLI GYNIVNFDLP YLIERADHLG VTSGSFLGRV KETKSVIKEA
     RFSSKAYGTR DRKDINIDGR VQLDILQAIL RDYKLRSYSL NSVSAHFLGE QKEDVPHNII
     TELQNGTNDT RRRLGVYCLK DSYLPQRLMD KLMLLVNYME MARVTGIPFN YLLTRGQQIR
     VISQLYRSAV LQDFVIPAMD VERGSGTDQY EGAIVIEPMR GYYDVPIATL DFASLYPSIM
     IAHNLCYTTL VSRVAIERLK LVEGEDYIIT PTNDCFIATK KRKGLLPYIL EQLLLARKTA
     KRDMAKETDP FKIQVLNGRQ LALKVVANSV YGFTGATIGR LPCLQISASV TSYGRMMIEA
     TKSSVEEEFT KEKGYDHDAI VIYGDTDSVM VKFGTEDLKE SMRLGKIAAD LITERFVSPI
     KLEFEKVYFP YLLINKKRYA GLYWTKAEKY DKLDTKGIET VRRDNCPLVQ ALVEKCLRLM
     LIDRNVEGAV TFAKQSISDL LQNKVDLSQL IITKALSKTD YAGKQAHVEL AERMRKRDAG
     SAPQVGDRVA YVITKASKGA AAYEKAEDPI YVLNNGLPID TKYYLENQLV KPLTRIFEPI
     LGDKVGNLFT GDHTRIIQLS APTKGGLMRF TVKSETCLGC RVPLKKGIDS NNKYSRAVCS
     HCLPKLPEIY LKNMKISNNY QTRYSRLWSE CQRCQSVMHE DVLCANSDCP IFYMRTKAQH
     DNNEHMKLMS RFEAAW
//
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