ID A0A1R2AP42_9CILI Unreviewed; 603 AA.
AC A0A1R2AP42;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
GN ORFNames=SteCoe_36947 {ECO:0000313|EMBL:OMJ66266.1};
OS Stentor coeruleus.
OC Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ66266.1, ECO:0000313|Proteomes:UP000187209};
RN [1] {ECO:0000313|EMBL:OMJ66266.1, ECO:0000313|Proteomes:UP000187209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM001 {ECO:0000313|EMBL:OMJ66266.1};
RA Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA Sood P.;
RT "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT introns.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMJ66266.1}.
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DR EMBL; MPUH01001767; OMJ66266.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R2AP42; -.
DR OrthoDB; 118994at2759; -.
DR Proteomes; UP000187209; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000187209}.
FT DOMAIN 269..386
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|Pfam:PF13401"
FT DOMAIN 424..472
FT /note="AAA lid"
FT /evidence="ECO:0000259|Pfam:PF17872"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 603 AA; 68945 MW; A83F5F080215B63D CRC64;
MVLTRKSSLK RKLTPDHHVP KTSKKPIVAH FNKEELQKMN IDLDKEYKQG KKPHLASRTP
LSRVQHPAPI EKPAKSYKDF IKNYQSREFT WEGSVDIKCT SQGKDLLIYN SVNFQKDTLA
SGDFVELVKE KETCYGQITY LFEENHKKYT ECRVFYQERL KHYIETYEYI TIPLGYIYKK
VIFTAENGFI CETLKDKSGK FIQVNPSYCL ERSLFRSKIA MRICANNSSL HKAISLLTLS
SAPSNLVGRT QEKQEILEFL ENSIKIGHSA NSLYICGMPG TGKTATFLYT IDSLRSREEF
SNSFTFIHVN CMKLSKPQEI YSILCKEICK RKKSGHEALE TINHYVKSSK KSGCIVILVD
EIDALLNKKQ DVLYNLFNWT NLYNSNFIVS GIANTMDLSD KFIHKVSSRM GNKQIVFAPY
SRDQLQEIIT KRLKDTEAFT PDAILFCSAK VASYSGDARR AFQVCKKAAF LALEQKELKI
SIEHIQKAFK QLFASLYVQA IQSLPIPMKL VLATLCLELK NNNKENAQID RIFYRLNSYC
ETLLLICCFS LKQVAVVINR LASLHLVAVD ENCVKLIVSP DDVIDGIKGD EMLAKLEPFL
LGN
//