ID A0A1R2AY38_9CILI Unreviewed; 3747 AA.
AC A0A1R2AY38;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN ORFNames=SteCoe_32920 {ECO:0000313|EMBL:OMJ69375.1};
OS Stentor coeruleus.
OC Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ69375.1, ECO:0000313|Proteomes:UP000187209};
RN [1] {ECO:0000313|EMBL:OMJ69375.1, ECO:0000313|Proteomes:UP000187209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM001 {ECO:0000313|EMBL:OMJ69375.1};
RA Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA Sood P.;
RT "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT introns.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMJ69375.1}.
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DR EMBL; MPUH01001206; OMJ69375.1; -; Genomic_DNA.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000187209; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 7.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 1.
DR SMART; SM00382; AAA; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000187209}.
FT DOMAIN 3547..3737
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 3057..3386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3401..3422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3078..3101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3108..3189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3190..3211
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3212..3277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3285..3315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3344..3386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3401..3415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3747 AA; 430136 MW; 9F270E4258FFD20A CRC64;
MSCRKRAKIE RKVYKTTEKV TSSLFKLNSC LPLSYGICIL GPPSSGKSAL FDIWSQEHGK
DLLTVHIDSS VDSKNLIGTY VCGETPGEFI WKTGILTYAV TSGKWLLFEN LDRMGDDVLA
LLSNLIRTNR LEIPNKNDRS QDDFKDKELG RSSIIPADGF KILATCTKPL DESSCFITIN
IVEFNVKELW DIRPGSLITE EFAGVFSDIH TQMGLLPGRE LVTGDWEKLI KRSSWQIERI
YGRKGIVNGL LTENCKENIL IECLCVYSGI RDPQAVLEKI TSILGLDAKS SEAFVQNRVI
RVLRKEHTME IGISPSLKVK NSIQEGLSLN AYSLKIIEKI SSCVAFGESP LLVGETGCGK
TSFVQFLAKF MDVKLYVHNL SQASDPSDIV GGFKPIAVST LLMPIITYFF KTLPKISDNS
VNSAVKSGIQ HAFRKKNWEK CVSLLDVAVC ELEKIYPSDK KVRKLWDKVQ DVKRKLKNSQ
FAFQFVEGSL VKAMKEGSWV LLEEINLAEE EVLERLHSVL EGKGIHLIEK GEIHSVQASS
GFRLFGCMNP GKQVGKKELP QSLRSKFTEI LVPEMEKFED VLEVVRFYLE GKADRRTMEN
IVNFYLEVRK LSKEGLIEDG CGRCPQYSMR TLCRSLRYAL EFSHHYSFSV SLYNGIKVFF
ETPLKGSLDS LLQKLTPAPT HPQPSIEKSH LNIQGSFHER GPKSLFEDPH FILTPSVKKN
LTVLSRAVIY QNNSVLLEGP TSSGKTSMVK YLAGLLGHEF VRINNHEHTD IEEYIGSYVS
DSHGRLVFCE GPLVKAVRHG HFLVLDELNL APSEVLEALN RLLDDNHELF ITETQETVKP
HKNFRLFATQ NPTSYAGRKE LSKAFRNRFV EMFVPELPDD ELIKILEIKG RLAPSYALVL
INIMRDLQRQ RQQTRAFLGR HGFITIRDLL KIAKREPMGY EELAHFAYMV LAERLRSDEE
KKLVQEVIEK HCKKAKIDIV AFYDKYFDNN YKKQVDTIIW NTHMKRLFCL VNSAISKNEP
VLLVGETGCG KTSICQALAE HYIKPLRILN CHQHTETSDF IGSLRPVRNK SLLISSLLTD
LSPYIPEISS YTLEDIFIKL QSLELPLDTL FLLSQRLKKA MTLFEWVDGP LVQAFIQGEY
FLIDEISLAD DSVLERLNSV LESERKLLIP EKAVEVVEDV GESGSEKSAG KIQVTGSEEM
EAHEGFQIFG TMNPGGDYGK KELSPALRNR FTEIWVAISI EDMREIVSKK TENHKELMSF
IENYNKTARV GLSLRDALTC ADFMNKHISP NSLWEGLALV LPTESLPNLP QNYVVTSSQG
LFGISPYYVS CSNTVSIPYS FQGPQVLKNL YSLLRAMMLS KAILLEGPPG VGKTSIIEAL
GKVLEIPVVR VNLSEETDLI DLLGCDLPSG DKFEWCDGVL LNAVKTGKWL ILDELNLCPQ
QVIEGLNALL DHRATVFIPE INQEVKCAAG FRLFAAQNPV SQGGGRKGLP KSFLNRFTKI
YMHDLGQEDY LAILNNLFGI ENNDQIIKMS LGLKTGLDGP WEFNLRDMLR WKEGGKIEVL
YYSRLRTQTQ KEIFTQIYNK SFSQEFITPN PPFYRILHQA IFLSEKSFPI SEIEEELIPK
QLKVLKDFCD IIYNSWPVLL VGSKGCGKRT IIKIASKIFG AELIQYSLSA NSDSGTLLGS
FEQSENGKFE WFESSLIRAV KTGQWVLLKN CNKCPAAVLD RINSLLEPGG QLLINERGLV
NGQSYVVYPH PNFRIIFSYN PMIGEVSRAL RNRCVEIFMD AEYSYMDFCR IYPLSYDEYE
SVKENSITEL AKWKYLAEVC DRKKAYEIVY NKGYCFMECE NEKIFEPLKS MLIDPLRGYF
NEDSWFLIRN GGIDEAKECF MSNGCVADME DRMRYVGINK GVEVFKDLKV ENVHFPVLNC
LDELKFYIEM SLIVSKKFMK LERIEDLTGY WYLMKCQKPY SRYKYSKRLP QDIQEPSPID
QGLLCSWKNR LSSHVQYPYD RIDKAQKLLT VFEFNCIMNG KDIGIGVGRK VIKVIDEDFN
EKEIGILASK ENYQSEERLY LEEVADCYEQ VLFKYLITCM DNNKDSDLSL NFYPKSYLMA
LWIHKQPKSS LREITLPILK APTSGYVDFL NIYETMKDCT IIDAPKYWSI ATNMLKWPKV
QETSYLPTIY LDDLSQELEK TCETDQFIIK FLKLSRILGL GIWLYKLYIK INIDPCTIHS
DLQDDYIKIM QIVEKNIKIR MDYHNFRMGY YWENELIKYY RKVLQTTQEK AKKNSIKVRK
PEPDSGKFIE YVKNLPSYAR LCTLFSQDMN KESISFLQQL LQSLIQNVGK FKTTLSLPLM
ESLHLMLFSL NTLTRNDRVY EKFPIELNDF PDVLIKAHLF AKHDFVESLC KRIKDAIQKP
TNPEKKMQVI EIKESRTVHT VGEKDRNTNE KDIEEEEKRQ VAKVFPTYSE EKAWSQVVLK
QRNDIVQILY DWEFSCGNHP QELEKKFLSY LSYNYPGCSL HTSLEVHIRC CLKHYDKNID
LFNFYKDPNP GEIMRSYTPL INLAERLHEL SLLFPEHAVL QDLQMLVYRV LKRPLFTTPL
MQFVSAINII VKKTEDWENF AHEGISMKKH ISEIYSVLRK YQELELKSWE GILESYKRGA
VEKDSKLWAR LMRVIFVEKA AEKPLFEALD MYMRSSTLGV FDFRLSLLKS LIPMVLPEQR
LSIYHISSYY GYFKQKYESI FSQHKEEAQN RLKEILQVAK YKMSNYLLWK DTTNKSHKQL
NSMINSYKNV LKMSFEKEVL EKHWFGYEIN VIEEKIKVYD EENDGNIYED LCTEIFQRLK
DLKDLSEQGG KRLALADLMK ELKNLGFSPY FKKWDDSCIY ELPILNPPND ADIEKAEKYF
YGCVDKLNVL QFSWGKNHDL LHEDKERCFG FVTDCVHKLM TIRVQLANEF NEYYKSLELP
QNLTSLLNEI KTFIENSLFT EWQNSLATSS PLPKFSTFAI TNTLLDLQSA YNSLKSLSEL
PNQTQKSLSY IELLPNIPIT KFSSSTIQNY KSLGKLAYIL LSIFLSLFTQ GFCIPPEEQS
EKSGEDGTGL GQGRGEKNIT NELEDEEQFG EKASQEENSE NSQEEDKNEE AFDFKEDFKE
DEERSANESE GEDRLGEAEG NEELMDKDQE VRDGEGEVRE TANPEKTDEQ DMREGILPED
RTGDIEDFEM QGRESEEDDE EGEESEKSEE NDEKSDEMMD VDKKDQESSE DENMSEENAK
DQDEEMKDME KDEEKVGEEE KDEEEKRLEE FKSREQVKYD QSAYGNEDLP SNTEKMQEGG
ESTEKQGSGE NIISKLKNDW SAAPQKASEV GPKSEKADQA TLFDIQIVRS SDQPQGPEDP
SLYSFNESHP DIAQAPSLNN PSEVPDFSAK NIQETLIEQA KQKDNLDQAN PSTDNAPHKP
EDIPMQPFYE MYTFKEHLVA YSSKPIQGSL PNIKPQVCED YEILQIPGLS LNTEEWLMLE
KDTHQISCDL CEQLRIILEP TKARSLKGDY KSGKRINMKK VIAYIASSFR KDKIWLRRTR
ETGREYQVLI AIDDSFSMNQ HGLGIIAKKG LAAIAQALNK LEVGELAVAA IRSGLTLLHN
FTSSFTAENG AYVLSELTFQ YGREAGNDLS YTNFVTQSQV FLAKHGSNDL QLVIIISDGR
LNKNKVRPCL RKSQGIFYLF VIVDNSESSI MNMKSTVVEK VEGKNKVKVY PYLEDFPFEY
YVVVQSPELL VRVLADITKQ WFELMRS
//
