ID   A0A1R2B0U2_9CILI        Unreviewed;      1165 AA.
AC   A0A1R2B0U2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein {ECO:0000259|Pfam:PF07699};
GN   ORFNames=SteCoe_31618 {ECO:0000313|EMBL:OMJ70413.1};
OS   Stentor coeruleus.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC   Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX   NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ70413.1, ECO:0000313|Proteomes:UP000187209};
RN   [1] {ECO:0000313|EMBL:OMJ70413.1, ECO:0000313|Proteomes:UP000187209}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM001 {ECO:0000313|EMBL:OMJ70413.1};
RA   Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA   Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA   Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA   Sood P.;
RT   "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT   introns.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OMJ70413.1}.
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DR   EMBL; MPUH01001090; OMJ70413.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R2B0U2; -.
DR   OrthoDB; 210887at2759; -.
DR   Proteomes; UP000187209; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00185; TNFRSF; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 3.
DR   Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR   PANTHER; PTHR46093; ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5; 1.
DR   PANTHER; PTHR46093:SF17; MULTIPLE EGF-LIKE-DOMAINS 8; 1.
DR   Pfam; PF07699; Ephrin_rec_like; 1.
DR   Pfam; PF13415; Kelch_3; 4.
DR   SMART; SM01411; Ephrin_rec_like; 1.
DR   SMART; SM00612; Kelch; 1.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF117281; Kelch motif; 2.
PE   4: Predicted;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187209};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        767..784
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        817..837
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1056..1082
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          666..705
FT                   /note="Tyrosine-protein kinase ephrin type A/B receptor-
FT                   like"
FT                   /evidence="ECO:0000259|Pfam:PF07699"
SQ   SEQUENCE   1165 AA;  133031 MW;  9EB35D59A8F4F6CA CRC64;
     MLYLLFSLVH SLHIEPLPTS LTPPTSRRMV SSIHSDIDNS AYLFGGGSQS GDPYSDELWK
     FSLDDYKWSQ VNLNTPVIPE GRVGCAMATH EEYIYVYGGA CDHGPSADFW LYSLEEAIWT
     EHNIKGDKPG PIAHPAYSNF EYKGVNYMAM FGGFNSEIAT NELYLLDLEN EIWTYYNSST
     TKPMPRIGAR MEYYNDHLYL WGASQDGDKD EDLKLYRYSL EDQSWSVIET YYMDNMDSRS
     FHGVYCWDEY FYVFYGVNMN DAIEFDSVLM VPLTGGNWTE LELNFKITIG MFATVLNKET
     VWIFCGGDTE GEYNSVYQIN LTSKIITEFF PDTYIFHRRH SYTFFRIGTD LLLFGGADSE
     QVYDDLYKYS LMTLQWQSVV ASGDPPSARY GHCASGYQGL YLIIFGGRNF DTEFNDMFQY
     NLRTNTWSTI IPHPEPAPRY GCCMTTHEKF IIIQGGETPS KVTNEIITID LHNHELSIVD
     NFNLFEKELN IRNHKCWSRH SSDGVTLELL VATGENAYGQ VLKHVFVITF DIDNKVNEAV
     VESLIYLNES QSWAAAGVIA MSNTFLIIGG TKRAMYASNK IFSISSRKSS NEVVQLEIIY
     EDNTTAYWYN HDIEHYMRNI YIGFSGAYFA NMVKEHKILS HVYRIHPSDI IDDYKYIECS
     AGTYGENCDP CRPGTYKEDV GPDDCLECPI GTYNPNNSSI SIESCFPCKF GFFANKTGME
     NCLHCQPNYY CPVGSNKETF RYYRDDVLSH QPANYASNIS DPFDGKIYYF VYLTGMMMFL
     IYIFNSNFRN KLSRIDYFSE KHETKVGQPV IKLRTSLGGL FTIVFFVFQV IYISQAFNNY
     RYDNILETKA LVPAIIRDDV FKASEFVVET ELLYYPGSCT QPYPKTKEEE NTCTEYLYET
     YEDIQGETKC SKNNKTDTCT LTFKCQDCYL TGDSSIEYRL CEYGSLASGI KVSVRSPSSI
     PGEYSEEAYI LEFINGTVLR GDASSEFFFE VTRSVFESDS SDWTTGTTGY HIGRMSDPNP
     GDHLTGDDIY FEPCVSLKIY LNMNGSVLVT RRIFKLAFML MITTSIASVF GILEMFGLAM
     IMSEKAEGCL KRKVKSIKDL NSVISARGYI CHSFEYGENE KSSGKINKSS FYPSTYGNAS
     HKITPTLFLS PEKFVDTTQN IDLDL
//