ID A0A1R2BL06_9CILI Unreviewed; 4297 AA.
AC A0A1R2BL06;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=SteCoe_22920 {ECO:0000313|EMBL:OMJ77483.1};
OS Stentor coeruleus.
OC Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ77483.1, ECO:0000313|Proteomes:UP000187209};
RN [1] {ECO:0000313|EMBL:OMJ77483.1, ECO:0000313|Proteomes:UP000187209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM001 {ECO:0000313|EMBL:OMJ77483.1};
RA Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA Sood P.;
RT "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT introns.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMJ77483.1}.
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DR EMBL; MPUH01000573; OMJ77483.1; -; Genomic_DNA.
DR OrthoDB; 176993at2759; -.
DR Proteomes; UP000187209; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000187209}.
FT DOMAIN 1595..1734
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1876..2040
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2260..2404
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2101..2128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 141..168
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3083..3120
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2101..2119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4297 AA; 496475 MW; 24292FD87F46EBDB CRC64;
MKRNKEFRVS KRRTPSKQSI SESSPHALTN FSPNHELSSC FSEFNLTINL KLPEPEHKNL
AESFSSPSLA QGIEYDSTVF KILPSLKKKH MPGSFLSLKH AEEFTKKLSK QTRKSVIKVP
KVLIKKCTKK TKSKDFNPNF RKNDEQSLEK YQEKEQEELK NARKYIQKEK LPLHFYDPII
DPLTPKTMIE SRKKSPDDKV RAYSKWFDSN GVCNWKKCFV ESYDDKLDKY KITWETGGQK
YATRINLRFE DEDPLRFEIR ISEAKNYRDA IENNYCYNIF VSNHVKSHIH LPVRVLENIF
IYVRSENLQN LDSYKDLLIS SHKYIDNIHN PSMFLWKNES THFIDENYIY KSKGFENQNE
YMESFIKNIP EFQLFIYPKY DRIIVGKDKI IALIHDFKDH WKMVCKHIDY KMQKLKIQSI
INSPYVVGDK KVKKLLTVNN SLKGSENMIR ILDEMNGKCI YNDVARIKIM QKLNDIIISW
KDLKMLPEKL SPEGLVNGKK GSGIAVKYKR SRTMSMDELM MIYNNSMNEF LKEAQNALFD
IQYEIQDILT MEDKKRLERN ASKLKARAYS KQSVDLEHSL PTELLEIFRK FTFVCNLRIE
TSLRNIIFTS LEHFYQRIFI PIEKISHKLE AKIDLTKKDF LSSNDQSYGL LNVNLTIDFQ
SKKIITIGFG ESFCSEILSL IKNSIKKLEN VKCLFTTQTG PSRSSSFLCI SEISQGKLEK
FLSKIEKVLI CQQYLLQKYV GTIEKFSFVL DIEPKKWVSK YANDMNIDKM ENEIFRLKRI
KVDILEVIGK SNRIVGIWKI HSSNVRDVMI DIIDKTIEEL TKLLQNDCLN KVKQIQEMYE
EIEKIISYIP KNLEELEEIK TFISNNFAVK LDFIEQEVTM IMGNIEILEG YWIFIPFEMY
KESWTCIGYS NNLKNLKEKC LKTLNILIVN FTQQLNDQKM NLHKEINETS IKLLNLKKQD
NYQKYEQLAC EFGMMQENIQ KFTEVVKVVN VRESIIGQIQ TDFKLLTDIK TDFTPYCKLW
FYIRDFLDRH PIWMNGPIGN LHRDAIANEL AACVNELSRY ERGVFKNDPA PLRLIKDYIS
EVNNFRPYLP IIRCVNNPGM KERHWLEFYT QSGIDLSHCH GNSLLSIVSL GVLDFIEQLE
AVSDLATKEL GLENAKRKME NEWAHIKFDL HPYKTCFILV NTEVIWDVLN EHLMRTNAMS
SSPYIQFLIN EITTWKQNLM KIQDILEEWE NFQHNWQYLQ PIFTNNDISK QLSQASNKFR
NINSQWENIM NSAHQNSNVY EFCINNLKLL DTLAYGNECL DSILKSLNEY LMSKRKAFPR
FYFLSNEELI LMLSNSQEIL TIQKYIVKCF EAIASVRVDI NNIVSMISPE SEEVMFENPV
AFYDKGEIKS LEVWMVELEK EMRGSLQIQL SIALQELNGF FLTDDSNIQD RSQGFIWGIK
EHNQDSELKS WVNRWPSQLV HASLMVVWTS NVEQAVIDNK LKDLIASEEE FLSVLVETVR
KDLRPLERLT FSTMVVIDVH NKDIAENLIK SQVTDLNDFA WFCSMRFYMQ EGKMRIKMLD
CIREYGYEYL GNTGRLVITE LTDRCYRTLM SALNMSLGGA PEGPAGTGKT ETTKDLAKIL
AKKCVVFNCS DRLDHIYMAK FFTGLCYCGA WACFDEFNRI ELDVLSVIAE QILSIQTAVQ
KQATVFKMDE EEIQLDHTCA IFITMNPDYA GRTKLPDNLK ALFRPVAMMI PDYAMIAEIY
LYSFGFRHAR ILSQKITNSL KLASEQLSTQ HHYDYGMRAV STIIKAAGWL KQQFPKDDEE
NLVLKAIKNT NIPKFINQDI PLFNGIVKDL FPSVIDKDEK DEELMDALAN AMIESMLIRN
QRFLSKTIEI YTTILLRHGL MIVGESMSGK TTALSILNKA LSYKNPVSCC YINPKSITLS
QLYGAPDPIS MDWKDGVLAQ AIREYSESTS KGYKWIVMDG PVDAVWIESM NTVMDDNKKL
CLPSGEIIKL TDSTRIIVEV DDLSYASPAT ISRCGMVYMD ADDILGPGAL IDQWVMYPPL
KFTTPRYKDL FKKLFKDIFF PVLEYWNTDL KCKRLMPITP SHAARNVITL FQALIIKKGK
SRKQHDQETI EENSNHPPSK PELLDDQSAS GSKSKEILAS IVSKSAIDQE VEKILHPKES
FIENNRISHL FIQAVQWSLA GTCDEEGRKL CSGFLYNICN ENYKIPVNFS EMYYNDVEMQ
WVSFKDLLTT PIKDPEITNT LVPTISLVSY QHLLNELIPR KVNTLISGLT GTGKTLLMKS
FLADVDKVFQ KATIMFSART SSGDIQTFIE SNLMKRRKGC IGPDTRKFFI FMIDDLNMPM
KEAYGAQPAV ELLRTVVERA ELYDRSTLEL KILEDVQYIC ILGKSGGYMV SQRFLARFFL
LAFDNYGKES LFKILSTLLD IGFANYPQCI LNSSSKVANG IISVYEKVLK DLPPTPTKSH
YTFSLRDLSN ILKGIFIVPP HKLTDIDSLC KLWVHECLRV FSDRLVDLND KEMLLDIVKY
SLMYNFNINW STFIPTEPIF CNFINDKVYQ EVTNVEKLKK FLNYECEEYS TNNTAGKMNL
IFFDYAIKHI CRISRVLLWN SGNMLLIGVG GSGRMSLTKL TAFVLKLDVY QIKLTKTYGT
SEWSEDLKTI LIATGQENKK LVFFLRDSDI IQESFLECIN SILNTGYFSN LFSLDEISSI
IESLKINKKY SQMSDQQRWD IFLSNIKRNL HIIMCMFPHG EVMRSRIRQF PALINCCVID
WFTEWPSDAL NAVAEHFLHN KSIADTPERR KSVIACCVYF HESVRELSEK YFEEYKRHNY
VTPTNYLHLL KNLKKLYKIK EDTTIKQTNK YSIGIQQLDL TQNYVQKLRS ELLALKPILQ
QKTISAEETL WQIQKENQEA DITRSIVASE QKASEEQTEI AEQIKKDCQT ALANALPELE
AAIKALDTIR RDDIDLVKTM RSPPDAVKLT LEALAIINNQ KPIKMKDPEN PNATIYDYFE
AGKKMLSIPK FIKKLKTFDR ESIEEETIFK LNPYIDLKKF HPDIVKYASS AAEGLCKWVR
AMYKFYHVNK EVKPKKASLI IAENDLKEKV KVLKIKQEEL RKVEEYITQL QNKLNLQIAE
TRTLSQEINK VEIQMDRAVK LIDQLGGERE AWTLKVKQYS KDMENLLGDV LMSAGVVSYM
GPFIWSYREY CLNQKWGPFV NSTGNISCSN TFSLPTCVGE PVTIQKWTLY GLPSDKVSIE
NAIIIEHSSN YPLIIDPQGQ ASKWLKKMLG QSTKQVFRVK MESSDFIQIL ENCLLLGADL
MIEDLKETID PVLDPLLLKQ FYLHEAEKVI KIGDVPRPYD DNFYLYLFTR LTNPHFSPEV
STKSTILNFC ITEEGLGEQL LDLVCRKEIP KDTEDRNKLT VQTVEYIKTM QALEDKILEL
LKSGGSTILE SEELIISLTK SKNLSTELEK KLANTKNAEQ RIINFQGNYK PAAKLSAIIY
FCITDLANIG TMYQYSMSWF INIFKKALSH AERSKDIAER VKNITLKFRE MIYLGIYNSL
QDSDRLLFVF LMSIRLMLYE KEIHPWQWRY FLTGICGIVE PIPNPTDFLS DKLWRDVVQL
DIHIEGLKDH VEKNQIIWKN FVSSERHWVQ LPTFEEFSQE LPEPYAYTTM MTRLLIYRAI
KPEALGVSIK CYVKSVLGEN FLKPNIFSMA KIVAEATVLK PILFVLTGGH DPQGIIKRYT
TESGIELKTA SLGKGQGERA EKIIKEAILA GNWVLLQNCH LSLSWLPTLE SILEQLTLDC
KDNSKVNEHF RLILTTVPTE GFSSSIIQKS VKVIAQPPGG LCNSLLGIYA NIENSKEETQ
FYESSEKPEV WKKLFFSLSF FHCVIRERGR FGPVGWNITY EFNDSDLGIS SKQLMQMVNN
FPNPPFEALI HLTASCNYGG RVTDDWDRRT LKEILLGFYH EEILDEKYTS LAPVPGYAIP
CENGLQDIAI AIKEFPQVQS PEVFGLHPNA EISKSIREAY NLCSRLLALQ PRALSISFDE
QKSAIFSLSD TIVSKVVKPF DLALISVKYP VTYYDSMSTV LTQELARYNG LIEVIKSSLI
TLKKAYEGIV LITPEYEILG ESLLKNEVPK LWKQASYSSC KSLVSWTDDL KKRIDFFNDW
IEYGRPKVFW ISGFFFTQSF LTAVLQEYAR NNKLPIDTIN FSFEVLDKEP DLLPESGALI
KGLYLEGACW DGTSLSECKL RELYFEFPLI WLKPSNNLSI DHSQYYTCPV YRTLSRAGVL
STTGHSTNFI LAVYLKTNVD PSHWVKRGVA LFTQLDD
//
