ID A0A1R2BMI8_9CILI Unreviewed; 424 AA.
AC A0A1R2BMI8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=MHD domain-containing protein {ECO:0000259|PROSITE:PS51072};
GN ORFNames=SteCoe_22320 {ECO:0000313|EMBL:OMJ77966.1};
OS Stentor coeruleus.
OC Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ77966.1, ECO:0000313|Proteomes:UP000187209};
RN [1] {ECO:0000313|EMBL:OMJ77966.1, ECO:0000313|Proteomes:UP000187209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM001 {ECO:0000313|EMBL:OMJ77966.1};
RA Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA Sood P.;
RT "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT introns.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC {ECO:0000256|PIRNR:PIRNR005992}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMJ77966.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MPUH01000546; OMJ77966.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R2BMI8; -.
DR OrthoDB; 5353102at2759; -.
DR Proteomes; UP000187209; Unassembled WGS sequence.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd09253; AP-4_Mu4_Cterm; 1.
DR CDD; cd14838; AP4_Mu_N; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR001392; Clathrin_mu.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR028565; MHD.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR PANTHER; PTHR10529:SF270; AP-4 COMPLEX SUBUNIT MU-1; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF005992; Clathrin_mu; 1.
DR PRINTS; PR00314; CLATHRINADPT.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR005992};
KW Reference proteome {ECO:0000313|Proteomes:UP000187209};
KW Transport {ECO:0000256|PIRNR:PIRNR005992}.
FT DOMAIN 170..423
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
SQ SEQUENCE 424 AA; 48668 MW; 3DF72A6FDD1F027B CRC64;
MLSQLFVLSA RGDIIITRDF RGDLVKGTNE VFFRKFKLWD GEPPPIFSVE GVNFIYIKRN
GLFFVGTTTE NISPSYIFEM ILNLIRVIKD YCGVLSEESL RKNFVLVYEL IDEMIDYGHS
QSTSTEQVRP YIVNEPIVID SSSFSLKPSF FANSVPCTAV QRPVTNKKSK NEIFVDVLEK
LTVLFNANGY IMNSSLDGCI QMKSFLRNNP QLQLALNDDL VIDKTNAYGN LGLDDFNFHE
CVNTNEFKDS RILIISPPDG EFVVMNYRIK GDYQVPFRIF PYMEELNQYK LDFSLKVKSL
FPDKLHATNV IIKFNMPRSA NNVSFELPKK SVGQTTEYKE SDKTVEWKIE KFMGSTELSM
KTKASLSSPA TAKEINQISM QFEISMYNVS KLQIKYLRIA GQGNSNPYRW VRYITQSSSY
VCRV
//
