ID A0A1R2C4D6_9CILI Unreviewed; 2077 AA.
AC A0A1R2C4D6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=SteCoe_15204 {ECO:0000313|EMBL:OMJ83795.1};
OS Stentor coeruleus.
OC Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ83795.1, ECO:0000313|Proteomes:UP000187209};
RN [1] {ECO:0000313|EMBL:OMJ83795.1, ECO:0000313|Proteomes:UP000187209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM001 {ECO:0000313|EMBL:OMJ83795.1};
RA Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA Sood P.;
RT "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT introns.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMJ83795.1}.
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DR EMBL; MPUH01000291; OMJ83795.1; -; Genomic_DNA.
DR OrthoDB; 181147at2759; -.
DR Proteomes; UP000187209; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000187209};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..965
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1028..1050
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1057..1078
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1098..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1205..1223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1229..1248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1264..1291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1336..1354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1690..1713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1725..1744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1750..1771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1814..1844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1406..1541
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 1897..2027
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 736..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..761
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2077 AA; 234941 MW; 42D4A0A13BB568B4 CRC64;
MSLSAGLLLT KREQGKEFSR KIIISGYGSS INQSKNQNFL RSSMYTIGNL IPLSLYKTFH
SVICIWYLAI SILELTMPVY NHLTAAIPLC VYLLLNLTSI TYQFCVAAIR DRRKNSQMCL
AWNEKLFAKK MIKDINVGDI VXCVAAIRDR RKNSQMCLAW NEKLFAKKMI KDINVGDIVL
LQENDEVPAD MVLIASGNIN KNCYVDNSTV TGEVDLQKRE TSKETQALID SLDVNEAGIF
LNMIEGHIDV NDPDGLFQHF SGKIKLRGSP KSENLTLQNL LLRESKIKAS TWVFGIALYT
GKETKISLAS QNKNAKVSVF EKRLEFHMAI ICLCILIISL LHFLLSIFKS NEPATIENYF
LYVLLYHSAL PFPLLFTRKI GKLFYCKRLQ NTDKVGIRNP EILENLGQVE YIILEKNDIL
TNGMLKIRAC IVDNFMYLVD QDYDRSPSEE TCLLCPEIAN AIEPIRKKIE ENCDGSIKYF
MCLALCSSAY PQENDEYLTS SNEDHSLILL ASEVGVKLTY RDSKKAIISI IENNHEYKII
IFKEPSASSK RTRILLYSFE ENQYILLVKG PLEVMMEVVQ GSGTKFIENL KMSIPGIQVC
VLGMKILTKK EAEEFIFLYN NARKCPVNRE GRIEGVIEQC EEGLQWLGAV GIEDRIASEA
KSTVQALETA GIKFWIASGD NEENTVSAGL GSDIIKNSAE ILRVVSPESV EEVLTTFEDI
IRNKVLYEGF LKTRQDGLNS NRDPQGAEES KDRSADSKRS SRKGSEILRR ASFHPLISQL
SNVRNGTLNV SKSFNADIID YVLVIDGKCL DMAMKSLDAL RCLTILLFLA KSVCCFNMLP
NHKISLSSIL KYNFSFRPIF MAIGSWGDTG LLNESDISVS KYQSDIIIKH FSDIKDLVFY
RGINLYLISS KIVLMSLYFN VSFVVFLSLY HYLCGFSGTW IMNQEEIILY SLVLQVILFV
PIYIYDRVVC NDEVTDPEIY TLGVFNHMLR FVDFCEYLGL AALNGGLSAI FLYLTFDSLI
SLDGFTSSSV HISIYLYVHF TLILVGITLV ETSRYALSTL ISPALVLIIS LIYILSTYFL
PEHELYGAIG EIFKMPEAAI SAFITSAVIL GVYMIVKILK FFLCINYSHL LTAFYANSSR
LGILSRMQYY ENNLGKVFKA SDVTKDPDIE EACAIDPYSL RFTSEAKEKS FSNESSMVNE
KIYSIYMHFY SVCHVIIFIY SAFETDQLMW SEVILLFCAG ILCCFEALQF TRLYKENVLR
YTKVFLLVTN AITIYAICVL YSSFTLIFPI FPLFHVFLIS DSWKFYLIIM AGETILDICF
KSLVFGKNLG YLLSEYSLII IAICSIVATI AYKLEYSRRK EYLLISEVTV QMNKAENVLG
LLLPHFVMTR VKDGTRYISE DQGIVSVLFC NICDFEETFA DSSPYELAEF LDELFGKFDQ
LCEIVGVTKI ETVGKTYMAS AGLKDSEAEL DPIISQVSHA RRVIELGFGM IQIIQRAKLK
HKKLHVKIGI NSGRVQAGVV GYHKPQFSLV GDTVNTASRM ASTLTDYDCI QITTSTYELV
KSSQGICFIS HSSFVKGKGN MDTYLVKIGN RLDSSFADAS PLGDHKISVH LSSLSGIISS
HSTIPGLMPN ELKAEKNRKK SYAAELKLEE NPVFNQKSGK FIERISLLSI KCSENSDEKK
FRENTLENSY QIYFVGLIIA LCVYAAETII EIATVIVDNE KVRSINLWFS IVITVVYAIM
FMFFKNHYTN LIYSWLLTLS YLLPIGIIIL VDFYDEYTHT ELTAIKIAFH ALLFTHCSTL
LYKDISLCTL PVFLAWLLYI AIECPTPSGF LILMFIAVCI VSVYHKEITM RVYANLKTDA
DNELKKIQAL LTQMVPTHAY EHLMAEDFVI DKFSQVTMIY ADIVGFTAWS SNRTPEEVVT
MLNEMFTRFD RMCVEHNVYK VHTIGDCYVA MSYIGNNNRD PGQECLNILT FAKCMINAIE
EVNSQYSMGI SMRIGVHTGD VIGGITGKSI VRYDIYGNDS YIANQMESNG IAGHIAVSFV
TQALISRYRP SLYTFKEHKT ITVFDTPTKI FLLQDSE
//
