ID A0A1R2C4Y3_9CILI Unreviewed; 1208 AA.
AC A0A1R2C4Y3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN ORFNames=SteCoe_14837 {ECO:0000313|EMBL:OMJ84088.1};
OS Stentor coeruleus.
OC Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ84088.1, ECO:0000313|Proteomes:UP000187209};
RN [1] {ECO:0000313|EMBL:OMJ84088.1, ECO:0000313|Proteomes:UP000187209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM001 {ECO:0000313|EMBL:OMJ84088.1};
RA Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA Sood P.;
RT "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT introns.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMJ84088.1}.
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DR EMBL; MPUH01000280; OMJ84088.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R2C4Y3; -.
DR OrthoDB; 587035at2759; -.
DR Proteomes; UP000187209; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44129; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR PANTHER; PTHR44129:SF13; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000187209};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 894..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 959..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 984..1003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1024..1049
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1094
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 140..171
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 182..223
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 313..354
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 442..483
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 498..537
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 895..1105
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1208 AA; 139606 MW; 5A74492C1C9CBCEF CRC64;
MAKTVSELSF VNASLIESRS GRRLSKKEDS ERPYGLSDKT LGHMLSVMQG FDMELEPEKI
QDYDNITAVC HSNQEAIVGG CPSGLLIIWK NGNRAMHYNC RSSVNIVTHG QKHARIYAGL
ETGEIVRWAY TKDNNALIEI TKHKAGVTHI ILFEEDTMMI SASRDGKMYF WYLTAKKKPI
EFHEHQSEIT SLQLHDDETK FLTSSIDGEI LLWSLEIIES IHVLHRFRGS YGIEHIELNG
NTFFATDTKG ILAKWSLEDY SVLHSVELPS KVVSMCKSND RRYLFLILQS AIEFSIKVVT
IDKFESEKIF TIPNAHTQQV NAVRAVPKGN KVITSSKDGS IKIWDFDEKY DTYLVINRNI
DINCIAANES LNLIVCGDTE GKVEMYTLGG KKLERELKTV TKCEINTIAF TNDLKYVAVG
CEDQRILLWH AKGFAKEEWI VFKEHSEGIT SICISLDSRY LISASSDRTI KIFDIVYQRL
EKTLSSNKSD DNSGRGEVAG HKKDVTDVKV TKNYIYSSGA DGFVIIWSIK TFAQLKKFEF
GQEITTLCPS IKEDCFAVGG KSNVIKIWWD FMHVPYVFDA EGHEGDVIRL IVYGEENFMY
SIAKDCCLKI WSLDQGLILF SLKIDEMVNF YVPKEQRLIY VVLFSKENNI STIKKVQNPL
FGDNITIYPP HYSYFFKTYV KKIQSHETKI YDSYWQDYMI FPHCVNLAYS FIFANRPNLL
KQSFAQGMKF LKSKAHESPL SWALFRNNSQ CADVILKKLS KISLKHQRVI IEAVEKEMNQ
LISRNLTCLP LLYENLFEVL TENVDAAGKL KKKAPMIAIS DDRILCQDDF FDRSSSLHKK
EFLEFRMSLC RFQLELGSIE SLKLLGSITD CHNSELFKTQ LLKAFLTFKW RQNFYILILE
TLLYCTNLTF LTIFVINSKS GNQSGILSIL LLLNSLNLIQ NGTKCYYSIY RFFRSTWNIL
DLCRLILSFF FIFYQFTAEN PEDFGLELLT LCYWLKAMGY FRIFNKYRYL LRVIMEIIKD
MTPFFLILFT STIAFAILLC VSQDGISFYN SFVNLYLLDQ TNFVIKLDSF ENDIVFFLAS
LLNPIIMLNL LIAIMGDTYD RVQEDQIVAD YREMTELILE AEYLAFWRRS NKGLLMYITR
CDYMRNLNLE KNQWMGKIKA VKKSLQILEG KFKSTSRTID SVQFNLLDRF NEVVTQSSIL
SKRLKDIK
//
