ID   A0A1R2CH51_9CILI        Unreviewed;       665 AA.
AC   A0A1R2CH51;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN   ORFNames=SteCoe_9767 {ECO:0000313|EMBL:OMJ88352.1};
OS   Stentor coeruleus.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC   Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX   NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ88352.1, ECO:0000313|Proteomes:UP000187209};
RN   [1] {ECO:0000313|EMBL:OMJ88352.1, ECO:0000313|Proteomes:UP000187209}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM001 {ECO:0000313|EMBL:OMJ88352.1};
RA   Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA   Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA   Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA   Sood P.;
RT   "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT   introns.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OMJ88352.1}.
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DR   EMBL; MPUH01000153; OMJ88352.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R2CH51; -.
DR   OrthoDB; 180294at2759; -.
DR   Proteomes; UP000187209; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF435; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG; 1.
DR   PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187209};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        91..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        164..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        202..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          459..551
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
SQ   SEQUENCE   665 AA;  77689 MW;  D59371D865D52853 CRC64;
     MKSKKLYLTE DFSERESPFQ SDDYPMILLG KNINPIHIDM LISSPRSDDP YASRLSQISA
     SLSSNKTEKK FRCTKARGLF RRLLIRRSHT FYKIWSITIE IVLTYNVITT LFFLAYEYPN
     GILLVCDTMS MCVFALEIIL NFFTEQEGKN SRTNKSFRSI AKNYSRGWLF FDILAILPLR
     LAGLEMEEYL LRMFRLFKLP KVMNFTDGNG LSYLLTYFQF GRREKNGKTT YSYKHKIIAS
     LVKLFIFTIF LVYFLGCFWF WFQRLIANYK YSQGPNEKDE NTFENAFGLQ EVGSLRLALI
     SSYYMFTTIA TIGYGDYTPK NVYEMTFTFI VMLFGATLIG IIDGNFNNAI SVYSDATCGY
     DIVGELHVWL GQLERVQGAL DSKIRDKIIN HFQNYSDKDR LKFLAKKYWE AKCLDDLVNI
     DQVYVRQLPE QAYNSIIQIL FTDFIHNFKY FLSLKVHLKI IPHLQPRKYE QNDLIYTQGE
     EIDELIFLLS GRISIGIIFD EKHQSLLVCE KGRTVIGDYA VLTKQKNNYD YLSEEYSESF
     SINGEIFMKI IENYFPEEKA SMLGMAVKRE NSLKKLKKNL LATLETEGSS PLKYKNKVSM
     IMPRDNHEFA YNEEETMKKI TRFMNLGADM SLKSEIILSQ IKSRDELRDI FIEGIDDELS
     PIYLE
//