ID A0A1R2CN71_9CILI Unreviewed; 1229 AA.
AC A0A1R2CN71;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN ORFNames=SteCoe_7177 {ECO:0000313|EMBL:OMJ90474.1};
OS Stentor coeruleus.
OC Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ90474.1, ECO:0000313|Proteomes:UP000187209};
RN [1] {ECO:0000313|EMBL:OMJ90474.1, ECO:0000313|Proteomes:UP000187209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WM001 {ECO:0000313|EMBL:OMJ90474.1};
RA Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA Sood P.;
RT "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT introns.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OMJ90474.1}.
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DR EMBL; MPUH01000102; OMJ90474.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1R2CN71; -.
DR OrthoDB; 5476119at2759; -.
DR Proteomes; UP000187209; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR011048; Haem_d1_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44129; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR PANTHER; PTHR44129:SF13; WD REPEAT-CONTAINING PROTEIN POP1; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF51004; C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000187209};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 901..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 963..980
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1015..1041
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1078..1099
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 151..184
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 194..235
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 279..313
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 321..354
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 906..1112
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1229 AA; 140983 MW; E74FA9526B89CF52 CRC64;
MLLSGVDDKP LMITTPMFTP TPSNKQGFSF PSITTDFDNP EFFLVSRPMA EELQDVSTYL
SEFRPSKIVT PFKGTSIAIS KDKSRFFFGS REGRVGVAKI ETKETILEID LKEGTIWAIA
LCENDRILFS GGRGGLIRKL STADMSQVAV LEGHNDEVNV IAISNDEKTL YSAGDDGQVI
MWDIMEISPK PNLLVKHSGM ICGMDLSKDN KYLASSSSSG VVSVYDLTEH KEIFREKNIN
NNAFWTVKIT QNNTWLVLGD SEGFLLIYSF GTWELIKNIK AHEDIIRSIV CTADEKKVVT
GSYDTKLKLW DLDWDSEPIV FQGHTELVKA LLLSDDSKTI YSLSDDCSIQ MWKIPPYKNN
SILSEEKTEN RPLYVGSQNR STLYTFGNKQ LGKYCHEKKY AIEYKNLELP SLVITLLNPV
KDEFVFIEMK ENEICYYYYY NSSSLKISDY SVTFVNPVTN EITRTGTLSL YNVCSAIFSH
DGKFLIIGES RRCSIFLAET LEKFHSFLSH KEEIKHLTLS LNGIYLFASD TQNIIKCLNI
INRTEVKGIK DIEAGDIEKM VVSRDNEFLV VLHKGSIANV WSISRMIKIS QISLEGVKDI
YYPSNADYMF CLYDFSIKAI NFPTFITCFE ITLPYKVEYF AFSHDFTEIY IKHLDGLTSW
TNPLSANKFL SFGHPTSVVK FFQYLGKLAS SRDDIYDPQY NNCVLEPFHI NMMHLYAYFN
KISSLTQCIQ ENCPFLISKS GYTPLDICLQ SNNDLGITLL YSKVKQETLK NPMFLSILEN
SITRICTSLS DKAYKFLDLS LSSSIDSTLT RYRHSNIPLP LFLYSPTLFC DKTLFSDLST
VSTEGETLQF FQTYFKLNMN PGSNDSINFV KALISTENET VFMSDFIKII LEEKWKKIRS
VLYIQSLLYL IYLIAISCYS TFEGMFLLIL SFVLNVILIL YEFKQAISSG SDYFSDIWNY
FDLLRLILAT LMFITDIISG NVYSEIIIAL VLLISWMRGI AYFRVFKATR YYINLIYEVV
LDIFPFLMIV FYSTLAFSFI FERVFRGTSD QVPDYFYYLS VSWELNLGTF SSSDYTTLMY
LAFILHAVLN PIIMLNLLIS VMSNTFERVN SQVEVADNKE LAKMILEAEL VYAWNRDNVE
KEYFFMIKGV EIEEIQDNTL AQVRNIKRKV GDMNRSQNMI SDSINGLLES IDEMKVTQTR
GLEQQEMIIE SQRNLENILQ EMLSATKSK
//
