ID   A0A1R2CWG0_9CILI        Unreviewed;       772 AA.
AC   A0A1R2CWG0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Histone deacetylase domain-containing protein {ECO:0000259|Pfam:PF00850};
GN   ORFNames=SteCoe_3701 {ECO:0000313|EMBL:OMJ93347.1};
OS   Stentor coeruleus.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC   Heterotrichea; Heterotrichida; Stentoridae; Stentor.
OX   NCBI_TaxID=5963 {ECO:0000313|EMBL:OMJ93347.1, ECO:0000313|Proteomes:UP000187209};
RN   [1] {ECO:0000313|EMBL:OMJ93347.1, ECO:0000313|Proteomes:UP000187209}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM001 {ECO:0000313|EMBL:OMJ93347.1};
RA   Slabodnick M., Ruby J.G., Reiff S.B., Swart E.C., Gosai S., Prabakaran S.,
RA   Witkowska E., Larue G.E., Fisher S., Freeman R.M., Gunawardena J., Chu W.,
RA   Stover N.A., Gregory B.D., Nowacki M., Derisi J., Roy S.W., Marshall W.F.,
RA   Sood P.;
RT   "The macronuclear genome of Stentor coeruleus: a giant cell with tiny
RT   introns.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OMJ93347.1}.
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DR   EMBL; MPUH01000044; OMJ93347.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1R2CWG0; -.
DR   OrthoDB; 69755at2759; -.
DR   Proteomes; UP000187209; Unassembled WGS sequence.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   CDD; cd11599; HDAC_classII_2; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000187209}.
FT   REPEAT          117..149
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          286..622
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          699..772
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        711..755
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        756..772
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   772 AA;  86684 MW;  C6F76DA11F29B8D1 CRC64;
     MSKGINEIEV DIHEICCLGR HSDLEEILNS IDFYADIMLE RDEEGFIPYH LSLIYCRHKC
     VDLILSLSID FQVPYQGFMP IHLAMACAGF PECHEDLIQT VNCLLKHKQD VTSRDRLGRT
     ALHIVCAYGL ADLIPILVQA GVKPELKDFS GKMPIHYAIE NYQAECFKQL LQEMGSDMFF
     CTDNRGDKPI HTSVRAGSWE CFNILITFGS EEMLNENNEF EETPEEVARN CGLYNEFVRA
     RQGDVFPSSA YKGTLLITDE TCKLHASIHE SLKTPQTLYK QIKIQPENPR RLEILVDLPF
     GALLTSDLSF ATWKKSSNPA HISDILRVHE YSYILGLKKA INKIPELSFP QKYDIDTLIT
     KESYNAALIA ANCVIEAIDE VVQGKFKNAF CVIRPPGHHV GPFGAVTAEE DPNSKSTGFC
     LFNNIAIGAG YAKYKYSKVI KKVAIIDFDV HHGNGTEAMV RNLIPNQVTH EITGAPFFGN
     LVYDSYKPWL DDDDYKNVLF ISSHAYGSDA YGRFYPASGK YCSSEELHPA GILNIPLSKC
     TDSSAFRQQY REKVFPRLIE FAPDLLLISA GFDAHGLDSI NHGFVDLDED DFRWVTEELI
     KIANTSCKGK IVSVLEGGYS VRGNVVAALG LSVASHIRAL IRATQEHFCG SEGNDNEKMI
     LKSSVNESFR ALKRNRKMYI ENLEVSMENQ LTAEVAEEFN GEKTQEVVSE ESGGDEDQDE
     NSEDESGNES EEGEEGEERE DNEEDDEEES EEEDSQESKK TDKANNGEPE DN
//